Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
hspb6Heat shock protein, alpha-crystallin-related, b6; Belongs to the small heat shock protein (HSP20) family. (139 aa)    
Predicted Functional Partners:
mapkapk5
MAPK activated protein kinase 5.
    
 0.809
bag3
BCL2 associated athanogene 3.
   
 
 0.804
LOC103475461
Crystallin, alpha B, a; Belongs to the small heat shock protein (HSP20) family.
   
 0.704
hspb7
Heat shock protein family, member 7 (cardiovascular); Belongs to the small heat shock protein (HSP20) family.
   
  
 0.703
LOC103464872
MAPK activated protein kinase 2a; Belongs to the protein kinase superfamily.
    
 0.667
MAPKAPK3
MAPK activated protein kinase 3; Belongs to the protein kinase superfamily.
    
 0.667
LOC103465075
MAPK activated protein kinase 3; Belongs to the protein kinase superfamily.
    
 0.667
tp53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
    
 
 0.632
ENSPREP00000011250
SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family.
      
 0.595
LOC103478507
Heat shock cognate 70; Belongs to the heat shock protein 70 family.
   
 0.589
Your Current Organism:
Poecilia reticulata
NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy
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