nup160 protein (Poecilia reticulata) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

nup160

Nucleoporin 160. (1398 aa)

Predicted Functional Partners:

LOC103461037

0.999

nup43

0.999

ENSPREP00000032333

0.999

nup37

0.998

sec13

0.998

nup133

0.998

nup85

0.997

nup98

0.996

Nup205

0.995

nup155

0.989

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000032333	LOC103461037	ENSPREP00000032333	ENSPREP00000019992	Nuclear pore complex protein; Functions as a component of the nuclear pore complex (NPC).	RAN binding protein 2.	0.999
ENSPREP00000032333	Nup205	ENSPREP00000032333	ENSPREP00000030838	Nuclear pore complex protein; Functions as a component of the nuclear pore complex (NPC).	Uncharacterized protein.	0.990
ENSPREP00000032333	nup133	ENSPREP00000032333	ENSPREP00000032294	Nuclear pore complex protein; Functions as a component of the nuclear pore complex (NPC).	Nucleoporin 133.	0.999
ENSPREP00000032333	nup155	ENSPREP00000032333	ENSPREP00000020739	Nuclear pore complex protein; Functions as a component of the nuclear pore complex (NPC).	Nucleoporin 155.	0.990
ENSPREP00000032333	nup160	ENSPREP00000032333	ENSPREP00000005366	Nuclear pore complex protein; Functions as a component of the nuclear pore complex (NPC).	Nucleoporin 160.	0.999
ENSPREP00000032333	nup37	ENSPREP00000032333	ENSPREP00000010359	Nuclear pore complex protein; Functions as a component of the nuclear pore complex (NPC).	Nucleoporin 37.	0.999
ENSPREP00000032333	nup43	ENSPREP00000032333	ENSPREP00000023665	Nuclear pore complex protein; Functions as a component of the nuclear pore complex (NPC).	Nucleoporin 43.	0.999
ENSPREP00000032333	nup85	ENSPREP00000032333	ENSPREP00000002916	Nuclear pore complex protein; Functions as a component of the nuclear pore complex (NPC).	Nuclear pore complex protein Nup85; Functions as a component of the nuclear pore complex (NPC).	0.999
ENSPREP00000032333	nup98	ENSPREP00000032333	ENSPREP00000003012	Nuclear pore complex protein; Functions as a component of the nuclear pore complex (NPC).	Nucleoporin 98.	0.999
ENSPREP00000032333	sec13	ENSPREP00000032333	ENSPREP00000023034	Nuclear pore complex protein; Functions as a component of the nuclear pore complex (NPC).	SEC13 homolog, nuclear pore and COPII coat complex component; Belongs to the WD repeat SEC13 family.	0.999
LOC103461037	ENSPREP00000032333	ENSPREP00000019992	ENSPREP00000032333	RAN binding protein 2.	Nuclear pore complex protein; Functions as a component of the nuclear pore complex (NPC).	0.999
LOC103461037	Nup205	ENSPREP00000019992	ENSPREP00000030838	RAN binding protein 2.	Uncharacterized protein.	0.996
LOC103461037	nup133	ENSPREP00000019992	ENSPREP00000032294	RAN binding protein 2.	Nucleoporin 133.	0.999
LOC103461037	nup155	ENSPREP00000019992	ENSPREP00000020739	RAN binding protein 2.	Nucleoporin 155.	0.999
LOC103461037	nup160	ENSPREP00000019992	ENSPREP00000005366	RAN binding protein 2.	Nucleoporin 160.	0.999
LOC103461037	nup37	ENSPREP00000019992	ENSPREP00000010359	RAN binding protein 2.	Nucleoporin 37.	0.955
LOC103461037	nup43	ENSPREP00000019992	ENSPREP00000023665	RAN binding protein 2.	Nucleoporin 43.	0.999
LOC103461037	nup85	ENSPREP00000019992	ENSPREP00000002916	RAN binding protein 2.	Nuclear pore complex protein Nup85; Functions as a component of the nuclear pore complex (NPC).	0.999
LOC103461037	nup98	ENSPREP00000019992	ENSPREP00000003012	RAN binding protein 2.	Nucleoporin 98.	0.999
LOC103461037	sec13	ENSPREP00000019992	ENSPREP00000023034	RAN binding protein 2.	SEC13 homolog, nuclear pore and COPII coat complex component; Belongs to the WD repeat SEC13 family.	0.999

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Network Stats

number of nodes:

11

number of edges:

27

average node degree:

4.91

avg. local clustering coefficient:

0.804

expected number of edges:

10

PPI enrichment p-value:

1.45e-05

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0007097

Nuclear migration

6 of 29

2.49

4.89

2.29e-10

GO:0051642

Centrosome localization

5 of 34

2.35

3.6

7.49e-08

GO:1902017

Regulation of cilium assembly

4 of 46

2.12

2.24

3.54e-05

GO:0046907

Intracellular transport

7 of 997

1.03

0.88

0.00086

GO:0033043

Regulation of organelle organization

5 of 761

1.0

0.51

0.0484

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0140444

Cytoskeleton-nuclear membrane anchor activity

5 of 11

2.84

4.97

5.07e-10

GO:0060090

Molecular adaptor activity

6 of 308

1.47

1.74

1.64e-05

GO:0051015

Actin filament binding

4 of 212

1.45

1.03

0.0045

GO:0008092

Cytoskeletal protein binding

5 of 842

0.95

0.5

0.0479

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0034993

Meiotic nuclear membrane microtubule tethering complex

5 of 14

2.73

4.85

6.70e-10

GO:0005640

Nuclear outer membrane

4 of 24

2.4

3.27

4.65e-07

GO:0031965

Nuclear membrane

6 of 179

1.7

2.6

2.05e-07

GO:0030017

Sarcomere

4 of 143

1.63

1.54

0.00031

GO:0098590

Plasma membrane region

6 of 773

1.07

0.97

0.00040

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:19246

Cytoskeleton-nuclear membrane anchor activity, and Lamin tail domain superfamily

6 of 18

2.7

5.78

7.80e-12

CL:19248

Cytoskeleton-nuclear membrane anchor activity

5 of 10

2.88

5.31

1.21e-10

CL:14822

Mixed, incl. EH domain, and T-complex protein 10, C-terminal domain superfamily

4 of 11

2.74

3.78

8.69e-08

CL:19250

Cytoskeleton-nuclear membrane anchor activity

2 of 5

2.78

1.52

0.0017

CL:14825

T-complex protein 10, C-terminal domain superfamily, and EH domain

2 of 5

2.78

1.52

0.0017

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1474165

Reproduction

5 of 42

2.25

3.45

1.10e-07

MAP-1640170

Cell Cycle

6 of 665

1.13

0.94

0.0014

Tissue Expression (TISSUES)

tissue

description

count in network

strength

signal

false discovery rate

BTO:0000562

Heart

4 of 225

1.43

1.5

9.65e-05

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0034993

Meiotic nuclear membrane microtubule tethering complex

5 of 12

2.8

4.99

4.16e-10

GOCC:0031965

Nuclear membrane

4 of 68

1.95

2.18

2.68e-05

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR012315

KASH domain

2 of 3

3.0

0.9

0.0241

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM01249

Nuclear envelope localisation domain

2 of 3

3.0

1.4

0.0029

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