ENSPREP00000005444 protein (Poecilia reticulata)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

ENSPREP00000005444

Uncharacterized protein. (225 aa)

Predicted Functional Partners:

stx5

0.943

uso1

0.812

LOC103475643

0.795

gosr1

0.795

LOC103478948

0.680

GORASP2

0.680

LOC103456555

0.680

gorasp1

0.680

gosr2

0.671

lman1

0.661

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000005444	GORASP2	ENSPREP00000005444	ENSPREP00000005849	Uncharacterized protein.	GRASP55_65 domain-containing protein.	0.680
ENSPREP00000005444	LOC103456555	ENSPREP00000005444	ENSPREP00000031781	Uncharacterized protein.	Golgi reassembly stacking protein 1.	0.680
ENSPREP00000005444	LOC103475643	ENSPREP00000005444	ENSPREP00000012832	Uncharacterized protein.	Golgi SNAP receptor complex member 1; Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor.	0.795
ENSPREP00000005444	LOC103478948	ENSPREP00000005444	ENSPREP00000003013	Uncharacterized protein.	Golgi reassembly stacking protein 2.	0.680
ENSPREP00000005444	gorasp1	ENSPREP00000005444	ENSPREP00000031935	Uncharacterized protein.	Golgi reassembly stacking protein 1a.	0.680
ENSPREP00000005444	gosr1	ENSPREP00000005444	ENSPREP00000031840	Uncharacterized protein.	Golgi SNAP receptor complex member 1.	0.795
ENSPREP00000005444	gosr2	ENSPREP00000005444	ENSPREP00000013210	Uncharacterized protein.	Golgi SNAP receptor complex member 2; Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network.	0.671
ENSPREP00000005444	lman1	ENSPREP00000005444	ENSPREP00000026702	Uncharacterized protein.	Lectin, mannose-binding, 1.	0.661
ENSPREP00000005444	stx5	ENSPREP00000005444	ENSPREP00000022289	Uncharacterized protein.	Syntaxin 5A; Belongs to the syntaxin family.	0.943
ENSPREP00000005444	uso1	ENSPREP00000005444	ENSPREP00000002486	Uncharacterized protein.	USO1 vesicle transport factor.	0.812
GORASP2	ENSPREP00000005444	ENSPREP00000005849	ENSPREP00000005444	GRASP55_65 domain-containing protein.	Uncharacterized protein.	0.680
GORASP2	LOC103475643	ENSPREP00000005849	ENSPREP00000012832	GRASP55_65 domain-containing protein.	Golgi SNAP receptor complex member 1; Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor.	0.435
GORASP2	gosr1	ENSPREP00000005849	ENSPREP00000031840	GRASP55_65 domain-containing protein.	Golgi SNAP receptor complex member 1.	0.470
GORASP2	gosr2	ENSPREP00000005849	ENSPREP00000013210	GRASP55_65 domain-containing protein.	Golgi SNAP receptor complex member 2; Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network.	0.571
GORASP2	lman1	ENSPREP00000005849	ENSPREP00000026702	GRASP55_65 domain-containing protein.	Lectin, mannose-binding, 1.	0.625
GORASP2	stx5	ENSPREP00000005849	ENSPREP00000022289	GRASP55_65 domain-containing protein.	Syntaxin 5A; Belongs to the syntaxin family.	0.685
GORASP2	uso1	ENSPREP00000005849	ENSPREP00000002486	GRASP55_65 domain-containing protein.	USO1 vesicle transport factor.	0.805
LOC103456555	ENSPREP00000005444	ENSPREP00000031781	ENSPREP00000005444	Golgi reassembly stacking protein 1.	Uncharacterized protein.	0.680
LOC103456555	LOC103475643	ENSPREP00000031781	ENSPREP00000012832	Golgi reassembly stacking protein 1.	Golgi SNAP receptor complex member 1; Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor.	0.435
LOC103456555	gosr1	ENSPREP00000031781	ENSPREP00000031840	Golgi reassembly stacking protein 1.	Golgi SNAP receptor complex member 1.	0.470

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Network Stats

number of nodes:

11

number of edges:

44

average node degree:

8

avg. local clustering coefficient:

0.825

expected number of edges:

10

PPI enrichment p-value:

9.21e-15

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009058

Biosynthetic process

9 of 320

0.57

0.35

0.0380

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005737

Cytoplasm

11 of 482

0.48

0.4

0.00045

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:993

Peptidoglycan synthesis, and Cell division site

4 of 18

1.47

1.08

0.0035

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00473

D-Alanine metabolism

4 of 4

2.12

2.46

1.11e-05

map01502

Vancomycin resistance

3 of 6

1.82

1.42

0.0012

map00290

Valine, leucine and isoleucine biosynthesis

2 of 2

2.12

1.14

0.0071

map01210

2-Oxocarboxylic acid metabolism

2 of 5

1.72

0.89

0.0174

map00550

Peptidoglycan biosynthesis

3 of 25

1.2

0.72

0.0174

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0573

Peptidoglycan synthesis

3 of 12

1.52

0.8

0.0214

KW-0961

Cell wall biogenesis/degradation

3 of 13

1.48

0.79

0.0214

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