snx6 protein (Poecilia reticulata) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

snx6

Sorting nexin 6. (366 aa)

Predicted Functional Partners:

snx2

0.927

snx1

0.865

LOC103465960

0.865

igf2r

0.780

LOC103461636

0.753

LOC103459747

0.753

snx8

0.745

snx30

0.676

snx7

0.676

LOC103480600

0.674

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC103459747	LOC103461636	ENSPREP00000026485	ENSPREP00000016066	PX domain-containing protein.	Sorting nexin 4.	0.901
LOC103459747	LOC103465960	ENSPREP00000026485	ENSPREP00000019194	PX domain-containing protein.	Sorting nexin 1a.	0.417
LOC103459747	igf2r	ENSPREP00000026485	ENSPREP00000026805	PX domain-containing protein.	Insulin-like growth factor 2 receptor.	0.530
LOC103459747	snx1	ENSPREP00000026485	ENSPREP00000009084	PX domain-containing protein.	Sorting nexin 1b.	0.417
LOC103459747	snx2	ENSPREP00000026485	ENSPREP00000027486	PX domain-containing protein.	Sorting nexin 2.	0.502
LOC103459747	snx30	ENSPREP00000026485	ENSPREP00000008011	PX domain-containing protein.	Sorting nexin family member 30.	0.852
LOC103459747	snx6	ENSPREP00000026485	ENSPREP00000005505	PX domain-containing protein.	Sorting nexin 6.	0.753
LOC103459747	snx7	ENSPREP00000026485	ENSPREP00000019923	PX domain-containing protein.	Sorting nexin 7.	0.855
LOC103459747	snx8	ENSPREP00000026485	ENSPREP00000012856	PX domain-containing protein.	Sorting nexin 8a.	0.454
LOC103461636	LOC103459747	ENSPREP00000016066	ENSPREP00000026485	Sorting nexin 4.	PX domain-containing protein.	0.901
LOC103461636	LOC103465960	ENSPREP00000016066	ENSPREP00000019194	Sorting nexin 4.	Sorting nexin 1a.	0.417
LOC103461636	igf2r	ENSPREP00000016066	ENSPREP00000026805	Sorting nexin 4.	Insulin-like growth factor 2 receptor.	0.530
LOC103461636	snx1	ENSPREP00000016066	ENSPREP00000009084	Sorting nexin 4.	Sorting nexin 1b.	0.417
LOC103461636	snx2	ENSPREP00000016066	ENSPREP00000027486	Sorting nexin 4.	Sorting nexin 2.	0.502
LOC103461636	snx30	ENSPREP00000016066	ENSPREP00000008011	Sorting nexin 4.	Sorting nexin family member 30.	0.853
LOC103461636	snx6	ENSPREP00000016066	ENSPREP00000005505	Sorting nexin 4.	Sorting nexin 6.	0.753
LOC103461636	snx7	ENSPREP00000016066	ENSPREP00000019923	Sorting nexin 4.	Sorting nexin 7.	0.854
LOC103461636	snx8	ENSPREP00000016066	ENSPREP00000012856	Sorting nexin 4.	Sorting nexin 8a.	0.454
LOC103465960	LOC103459747	ENSPREP00000019194	ENSPREP00000026485	Sorting nexin 1a.	PX domain-containing protein.	0.417
LOC103465960	LOC103461636	ENSPREP00000019194	ENSPREP00000016066	Sorting nexin 1a.	Sorting nexin 4.	0.417

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

24

average node degree:

4.36

avg. local clustering coefficient:

0.837

expected number of edges:

13

PPI enrichment p-value:

0.00571

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0048643

Positive regulation of skeletal muscle tissue development

4 of 8

2.88

3.63

2.02e-07

GO:0048743

Positive regulation of skeletal muscle fiber development

3 of 4

3.05

2.97

4.00e-06

GO:0042693

Muscle cell fate commitment

3 of 12

2.58

2.37

3.83e-05

GO:0045663

Positive regulation of myoblast differentiation

3 of 15

2.48

2.25

6.08e-05

GO:0045165

Cell fate commitment

5 of 150

1.7

2.07

1.25e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0070888

E-box binding

4 of 28

2.33

2.77

4.38e-06

GO:0043425

bHLH transcription factor binding

3 of 18

2.4

2.12

0.00010

GO:0046983

Protein dimerization activity

9 of 690

1.29

1.84

5.31e-08

GO:0140297

DNA-binding transcription factor binding

5 of 288

1.42

1.44

0.00015

GO:0000978

RNA polymerase II cis-regulatory region sequence-specific DNA binding

7 of 732

1.16

1.2

6.27e-05

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005667

Transcription regulator complex

7 of 333

1.5

2.12

5.73e-07

GO:0005634

Nucleus

11 of 5262

0.5

0.4

0.0021

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:38003577

(2023) Whole-Transcriptome RNA Sequencing Uncovers the Global Expression Changes and RNA Regulatory Networks in Duck Embryonic Myogenesis.

2 of 6

2.7

1.08

0.0112

PMID:37729680

(2023) Dietary zinc supplementation in breeding pigeons improves the carcass traits of squabs through regulating antioxidant capacity and myogenic regulatory factor expression.

2 of 3

3.0

1.08

0.0112

PMID:37170512

(2023) Current technologies, regulation, and future perspective of animal product analogs - A review.

2 of 4

2.88

1.08

0.0112

PMID:37108828

(2023) Sow-Offspring Diets Supplemented with Probiotics and Synbiotics Are Associated with Offsprings Growth Performance and Meat Quality.

2 of 5

2.78

1.08

0.0112

PMID:36697366

(2023) Genome-wide association studies demonstrate the genes associated with perimysial thickness in ducks.

2 of 4

2.88

1.08

0.0112

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:22056

RUNX1 regulates transcription of genes involved in differentiation of HSCs, and DNA-binding protein inhibitor

7 of 17

2.79

7.53

3.02e-15

CL:21810

DNA-binding transcription factor activity, RNA polymerase II-specific, and DNA-binding protein inhibitor

10 of 162

1.97

5.57

4.34e-16

CL:22058

RUNX1 regulates transcription of genes involved in differentiation of HSCs, and Runx inhibition domain

4 of 11

2.74

3.82

7.45e-08

CL:22080

DNA-binding protein inhibitor, and E-box binding

3 of 5

2.96

2.88

5.56e-06

CL:21814

Mixed, incl. Myogenesis, and Sox developmental protein N-terminal

3 of 34

2.12

1.64

0.00068

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-525793

Myogenesis

7 of 37

2.46

6.11

3.01e-13

MAP-1266738

Developmental Biology

7 of 573

1.27

1.45

1.48e-05

MAP-2559585

Oncogene Induced Senescence

2 of 11

2.44

0.96

0.0172

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005634

Nucleus

9 of 2704

0.7

0.51

0.0050

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF12232

Myogenic determination factor 5

2 of 2

3.18

1.3

0.0046

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036638

Helix-loop-helix DNA-binding domain superfamily

6 of 85

2.03

3.29

6.24e-08

IPR011598

Myc-type, basic helix-loop-helix (bHLH) domain

6 of 85

2.03

3.29

6.24e-08

IPR039704

Myogenic factor

3 of 3

3.18

2.79

8.71e-06

IPR002546

Myogenic muscle-specific protein, N-terminal

3 of 3

3.18

2.79

8.71e-06

IPR022032

Myogenic determination factor 5

2 of 2

3.18

1.41

0.0029

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00353

Helix loop helix domain

6 of 89

2.01

3.55

9.76e-09

SM00520

Basic domain in HLH proteins of MYOD family

3 of 3

3.18

3.2

1.57e-06

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