nrf1 protein (Poecilia reticulata) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

nrf1

Nuclear respiratory factor 1. (525 aa)

Predicted Functional Partners:

ppargc1b

0.833

ppargc1a

0.790

pprc1

0.708

tfam

0.689

LOC103465396

0.676

esrra

0.603

sirt1

0.559

LOC103477149

0.550

LOC103472203

0.549

rbm22

0.544

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC103465396	nrf1	ENSPREP00000000591	ENSPREP00000005610	Si:dkey-93h22.8.	Nuclear respiratory factor 1.	0.676
LOC103465396	sirt1	ENSPREP00000000591	ENSPREP00000003960	Si:dkey-93h22.8.	Sirtuin 1.	0.616
LOC103465396	tfam	ENSPREP00000000591	ENSPREP00000005388	Si:dkey-93h22.8.	Transcription factor A, mitochondrial.	0.519
LOC103472203	nrf1	ENSPREP00000001018	ENSPREP00000005610	Nuclear factor, erythroid 2-like 3.	Nuclear respiratory factor 1.	0.549
LOC103477149	esrra	ENSPREP00000002219	ENSPREP00000017666	Cytochrome c oxidase subunit 5B2.	Estrogen-related receptor alpha.	0.573
LOC103477149	nrf1	ENSPREP00000002219	ENSPREP00000005610	Cytochrome c oxidase subunit 5B2.	Nuclear respiratory factor 1.	0.550
esrra	LOC103477149	ENSPREP00000017666	ENSPREP00000002219	Estrogen-related receptor alpha.	Cytochrome c oxidase subunit 5B2.	0.573
esrra	nrf1	ENSPREP00000017666	ENSPREP00000005610	Estrogen-related receptor alpha.	Nuclear respiratory factor 1.	0.603
esrra	ppargc1a	ENSPREP00000017666	ENSPREP00000028362	Estrogen-related receptor alpha.	Peroxisome proliferator-activated receptor gamma, coactivator 1 alpha.	0.984
esrra	ppargc1b	ENSPREP00000017666	ENSPREP00000011351	Estrogen-related receptor alpha.	Peroxisome proliferator-activated receptor gamma, coactivator 1 beta.	0.862
esrra	sirt1	ENSPREP00000017666	ENSPREP00000003960	Estrogen-related receptor alpha.	Sirtuin 1.	0.456
nrf1	LOC103465396	ENSPREP00000005610	ENSPREP00000000591	Nuclear respiratory factor 1.	Si:dkey-93h22.8.	0.676
nrf1	LOC103472203	ENSPREP00000005610	ENSPREP00000001018	Nuclear respiratory factor 1.	Nuclear factor, erythroid 2-like 3.	0.549
nrf1	LOC103477149	ENSPREP00000005610	ENSPREP00000002219	Nuclear respiratory factor 1.	Cytochrome c oxidase subunit 5B2.	0.550
nrf1	esrra	ENSPREP00000005610	ENSPREP00000017666	Nuclear respiratory factor 1.	Estrogen-related receptor alpha.	0.603
nrf1	ppargc1a	ENSPREP00000005610	ENSPREP00000028362	Nuclear respiratory factor 1.	Peroxisome proliferator-activated receptor gamma, coactivator 1 alpha.	0.790
nrf1	ppargc1b	ENSPREP00000005610	ENSPREP00000011351	Nuclear respiratory factor 1.	Peroxisome proliferator-activated receptor gamma, coactivator 1 beta.	0.833
nrf1	pprc1	ENSPREP00000005610	ENSPREP00000030552	Nuclear respiratory factor 1.	PPARG related coactivator 1.	0.708
nrf1	rbm22	ENSPREP00000005610	ENSPREP00000005089	Nuclear respiratory factor 1.	RNA binding motif protein 22.	0.544
nrf1	sirt1	ENSPREP00000005610	ENSPREP00000003960	Nuclear respiratory factor 1.	Sirtuin 1.	0.559

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

45

average node degree:

8.18

avg. local clustering coefficient:

0.879

expected number of edges:

11

PPI enrichment p-value:

1.43e-14

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000281

Mitotic cytokinesis

6 of 32

1.79

2.63

5.40e-07

GO:0000910

Cytokinesis

7 of 53

1.64

2.48

2.15e-07

GO:1902404

Mitotic actomyosin contractile ring contraction

4 of 10

2.12

2.39

1.66e-05

GO:0032506

Cytokinetic process

5 of 41

1.61

1.85

2.79e-05

GO:0030036

Actin cytoskeleton organization

6 of 63

1.5

1.84

9.47e-06

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0051015

Actin filament binding

5 of 27

1.79

2.12

1.71e-05

GO:0005516

Calmodulin binding

3 of 7

2.15

1.67

0.00062

GO:0008092

Cytoskeletal protein binding

6 of 104

1.28

1.29

0.00014

GO:0000146

Microfilament motor activity

2 of 4

2.22

0.91

0.0210

GO:0005515

Protein binding

7 of 540

0.63

0.37

0.0457

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016459

Myosin complex

5 of 7

2.37

3.81

2.85e-08

GO:0015629

Actin cytoskeleton

8 of 71

1.57

2.69

4.47e-09

GO:0110085

Mitotic actomyosin contractile ring

5 of 22

1.88

2.66

9.48e-07

GO:0030864

Cortical actin cytoskeleton

7 of 57

1.61

2.6

3.22e-08

GO:0016460

Myosin II complex

3 of 3

2.52

2.41

3.11e-05

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:419

Actomyosin structure organization, and Calponin homology domain

6 of 17

2.07

3.64

1.01e-08

CL:421

Actomyosin structure organization

5 of 12

2.14

3.29

1.36e-07

CL:422

Myosin II complex, and RasGAP C-terminus

4 of 6

2.34

2.97

1.68e-06

CL:130

Mixed, incl. Calcium-mediated signaling, and Myosin complex

4 of 12

2.04

2.46

8.25e-06

CL:93

Mixed, incl. Microtubule cytoskeleton organization, and Regulation of calcium ion transmembrane transport

5 of 42

1.59

1.96

1.12e-05

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04070

Phosphatidylinositol signaling system

3 of 28

1.55

0.93

0.0110

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-5627123

RHO GTPases activate PAKs

3 of 6

2.22

1.76

0.00044

MAP-195258

RHO GTPase Effectors

5 of 74

1.35

1.25

0.00044

MAP-9716542

Signaling by Rho GTPases, Miro GTPases and RHOBTB3

7 of 162

1.15

1.21

4.45e-05

MAP-194315

Signaling by Rho GTPases

6 of 157

1.1

1.0

0.00044

MAP-162582

Signal Transduction

9 of 351

0.93

0.92

2.90e-05

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0016459

Myosin complex

5 of 9

2.26

3.54

7.20e-08

GOCC:0015629

Actin cytoskeleton

8 of 63

1.62

2.9

1.84e-09

GOCC:0005856

Cytoskeleton

9 of 197

1.18

1.56

7.20e-08

GOCC:0016460

Myosin II complex

2 of 2

2.52

1.27

0.0046

GOCC:0110085

Mitotic actomyosin contractile ring

3 of 17

1.77

1.22

0.0032

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0518

Myosin

2 of 3

2.34

1.13

0.0081

KW-0106

Calcium

3 of 18

1.74

1.12

0.0052

KW-0009

Actin-binding

2 of 13

1.71

0.71

0.0417

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR000048

IQ motif, EF-hand binding site

3 of 5

2.3

1.49

0.0016

IPR018247

EF-Hand 1, calcium-binding site

3 of 13

1.88

1.07

0.0081

IPR011992

EF-hand domain pair

3 of 17

1.77

0.99

0.0109

IPR002048

EF-hand domain

3 of 17

1.77

0.99

0.0109

IPR001609

Myosin head, motor domain

2 of 3

2.34

0.89

0.0237

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00015

Short calmodulin-binding motif containing conserved Ile and Gln residues.

3 of 4

2.39

2.02

0.00016

SM00054

EF-hand, calcium binding motif

3 of 11

1.95

1.55

0.00083

SM00242

Myosin. Large ATPases.

2 of 3

2.34

1.19

0.0062

SM00033

Calponin homology domain

2 of 4

2.22

1.15

0.0070

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (24%) [HD]

Permalink

Network

Cooccurrence

Experiments

Coexpression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2024

Credits

Access

Info

About