Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
abcc12ATP-binding cassette, sub-family C (CFTR/MRP), member 12. (1355 aa)    
Predicted Functional Partners:
abcg4
ATP-binding cassette, sub-family G (WHITE), member 4a.
   
 0.550
derl1
Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.
    
 0.539
gopc
Golgi-associated PDZ and coiled-coil motif containing.
    
 0.524
usp10
Ubiquitin carboxyl-terminal hydrolase.
    
  0.519
Katnal2
Katanin p60 subunit A-like 2.
  
 0.515
LOC103458407
Rap guanine nucleotide exchange factor (GEF) 4.
    
 0.492
LOC103475277
ATP-binding cassette, sub-family G (WHITE), member 1.
   
 0.479
abca12
ATP-binding cassette, sub-family A (ABC1), member 12.
   
0.453
ENSPREP00000002302
ATP-binding cassette, sub-family G (WHITE), member 2d.
   
 0.449
kcnj8
Potassium inwardly-rectifying channel, subfamily J, member 8.
   
 0.446
Your Current Organism:
Poecilia reticulata
NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy
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