LOC103475332 protein (Poecilia reticulata) - STRING interaction network

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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gene co-occurrence

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protein homology

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Score

LOC103475332

Interferon regulatory factor. (291 aa)

Predicted Functional Partners:

LOC103471006

0.772

myd88

0.730

LOC103468460

0.709

LOC103482005

0.709

spi1

0.659

stat1

0.641

stub1

0.638

LOC103465382

0.598

LOC103467592

0.595

ENSPREP00000024840

0.595

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000024840	LOC103475332	ENSPREP00000024840	ENSPREP00000005624	TIR domain-containing protein.	Interferon regulatory factor.	0.595
ENSPREP00000024840	myd88	ENSPREP00000024840	ENSPREP00000031341	TIR domain-containing protein.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.988
LOC103465382	LOC103468460	ENSPREP00000025000	ENSPREP00000026558	Signal transducer and activator of transcription.	E1A binding protein p300 b.	0.645
LOC103465382	LOC103475332	ENSPREP00000025000	ENSPREP00000005624	Signal transducer and activator of transcription.	Interferon regulatory factor.	0.598
LOC103465382	LOC103482005	ENSPREP00000025000	ENSPREP00000030842	Signal transducer and activator of transcription.	E1A binding protein p300 a.	0.645
LOC103465382	myd88	ENSPREP00000025000	ENSPREP00000031341	Signal transducer and activator of transcription.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.445
LOC103465382	stat1	ENSPREP00000025000	ENSPREP00000033192	Signal transducer and activator of transcription.	Signal transducer and activator of transcription.	0.679
LOC103467592	LOC103468460	ENSPREP00000011788	ENSPREP00000026558	Interferon regulatory factor 10.	E1A binding protein p300 b.	0.419
LOC103467592	LOC103475332	ENSPREP00000011788	ENSPREP00000005624	Interferon regulatory factor 10.	Interferon regulatory factor.	0.595
LOC103467592	LOC103482005	ENSPREP00000011788	ENSPREP00000030842	Interferon regulatory factor 10.	E1A binding protein p300 a.	0.419
LOC103467592	myd88	ENSPREP00000011788	ENSPREP00000031341	Interferon regulatory factor 10.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.466
LOC103467592	spi1	ENSPREP00000011788	ENSPREP00000033545	Interferon regulatory factor 10.	Spi-1 proto-oncogene b.	0.505
LOC103468460	LOC103465382	ENSPREP00000026558	ENSPREP00000025000	E1A binding protein p300 b.	Signal transducer and activator of transcription.	0.645
LOC103468460	LOC103467592	ENSPREP00000026558	ENSPREP00000011788	E1A binding protein p300 b.	Interferon regulatory factor 10.	0.419
LOC103468460	LOC103475332	ENSPREP00000026558	ENSPREP00000005624	E1A binding protein p300 b.	Interferon regulatory factor.	0.709
LOC103468460	LOC103482005	ENSPREP00000026558	ENSPREP00000030842	E1A binding protein p300 b.	E1A binding protein p300 a.	0.902
LOC103468460	myd88	ENSPREP00000026558	ENSPREP00000031341	E1A binding protein p300 b.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.438
LOC103468460	spi1	ENSPREP00000026558	ENSPREP00000033545	E1A binding protein p300 b.	Spi-1 proto-oncogene b.	0.583
LOC103468460	stat1	ENSPREP00000026558	ENSPREP00000033192	E1A binding protein p300 b.	Signal transducer and activator of transcription.	0.645
LOC103471006	LOC103475332	ENSPREP00000001253	ENSPREP00000005624	Interferon regulatory factor 2.	Interferon regulatory factor.	0.772

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

50

average node degree:

9.09

avg. local clustering coefficient:

0.894

expected number of edges:

10

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0007062

Sister chromatid cohesion

9 of 40

2.67

9.23

1.94e-19

GO:0007064

Mitotic sister chromatid cohesion

8 of 24

2.84

8.98

3.79e-18

GO:0071168

Protein localization to chromatin

6 of 11

3.05

7.22

3.71e-14

GO:0071921

Cohesin loading

4 of 4

3.32

4.95

1.03e-09

GO:0000278

Mitotic cell cycle

10 of 481

1.64

3.61

2.08e-13

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0061775

Cohesin loading activity

2 of 2

3.32

1.37

0.0034

GO:0003682

Chromatin binding

4 of 420

1.3

0.61

0.0465

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0090694

Scc2-Scc4 cohesin loading complex

4 of 4

3.32

4.73

2.55e-09

GO:0000794

Condensed nuclear chromosome

5 of 49

2.33

3.95

1.16e-08

GO:0000798

Nuclear cohesin complex

3 of 5

3.1

3.26

1.17e-06

GO:0000795

Synaptonemal complex

3 of 22

2.45

2.38e-05

GO:0034990

Nuclear mitotic cohesin complex

2 of 2

3.32

2.17

0.00012

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:7532

Cohesin Loading onto Chromatin

11 of 20

3.06

14.81

1.89e-29

CL:7535

Cohesin Loading onto Chromatin

8 of 15

3.04

10.11

7.26e-20

CL:7537

Establishment of Sister Chromatid Cohesion

4 of 6

3.14

4.45

7.59e-09

CL:7552

Cohesin complex

2 of 5

2.92

1.3

0.0044

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-2470946

Cohesin Loading onto Chromatin

11 of 20

3.06

15.04

6.30e-30

MAP-68884

Mitotic Telophase/Cytokinesis

11 of 23

3.0

14.76

1.06e-29

MAP-2468052

Establishment of Sister Chromatid Cohesion

7 of 19

2.88

8.23

1.85e-16

MAP-2500257

Resolution of Sister Chromatid Cohesion

7 of 165

1.95

4.08

9.21e-11

MAP-68886

M Phase

11 of 529

1.64

3.95

4.79e-16

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0032116

SMC loading complex

4 of 4

3.32

4.69

3.10e-09

GOCC:0090694

Scc2-Scc4 cohesin loading complex

3 of 3

3.32

3.31

1.02e-06

GOCC:0000793

Condensed chromosome

5 of 110

1.98

2.77

1.02e-06

GOCC:0008278

Cohesin complex

3 of 14

2.65

2.57

1.72e-05

GOCC:0034990

Nuclear mitotic cohesin complex

2 of 2

3.32

1.94

0.00032

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0131

Cell cycle

2 of 31

2.13

0.77

0.0368

KW-0539

Nucleus

5 of 1189

0.94

0.52

0.0368

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF12830

Sister chromatid cohesion C-terminus

2 of 2

3.32

1.41

0.0029

PF12765

HEAT repeat associated with sister chromatid cohesion

2 of 4

3.02

1.41

0.0029

PF07814

Wings apart-like protein regulation of heterochromatin

2 of 2

3.32

1.41

0.0029

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR033031

Scc2/Nipped-B family

3 of 3

3.32

2.9

5.87e-06

IPR011989

Armadillo-like helical

6 of 228

1.74

2.3

3.38e-06

IPR039874

Wings apart-like protein

2 of 2

3.32

1.48

0.0022

IPR039776

Sister chromatid cohesion protein Pds5

2 of 2

3.32

1.48

0.0022

IPR024986

Sister chromatid cohesion C-terminal domain

2 of 2

3.32

1.48

0.0022

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00968

SMC proteins Flexible Hinge Domain

2 of 7

2.77

1.23

0.0059

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