Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
KRT222Keratin 222; Belongs to the intermediate filament family. (536 aa)    
Predicted Functional Partners:
Unc79
Uncharacterized protein.
   
 0.676
LOC103466878
Keratin 5; Belongs to the intermediate filament family.
   
 0.669
has1
Hyaluronan synthase 1.
    
 
 0.532
LOC103464941
Keratin 4; Belongs to the intermediate filament family.
   
 0.508
LOC103466879
Keratin 8; Belongs to the intermediate filament family.
   
 0.508
ino80e
INO80 complex subunit E.
   
 0.503
cpsf1
Cleavage and polyadenylation specific factor 1.
    
  0.496
LOC103461037
RAN binding protein 2.
    
  0.491
LOC103478167
Ephrin-A1b; Belongs to the ephrin family.
    
 
 0.471
derl2
Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.
      
 0.466
Your Current Organism:
Poecilia reticulata
NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy
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