Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ecsitECSIT signalling integrator. (448 aa)    
Predicted Functional Partners:
traf6
TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.
    
 0.999
ndufaf1
NADH:ubiquinone oxidoreductase complex assembly factor 1.
   
 0.999
NDUFA13
NADH:ubiquinone oxidoreductase subunit A13.
   
 0.994
ndufs2
NADH:ubiquinone oxidoreductase core subunit S2; Belongs to the complex I 49 kDa subunit family.
   
 0.992
timmdc1
Translocase of inner mitochondrial membrane domain containing 1.
   
 0.992
ndufaf3
NADH:ubiquinone oxidoreductase complex assembly factor.
   
 0.991
ndufa8
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
   
 0.989
ndufaf4
NADH:ubiquinone oxidoreductase complex assembly factor 4.
    
 0.988
ndufb11
NADH:ubiquinone oxidoreductase subunit B11.
   
 0.988
tmem186
Transmembrane protein 186.
    
 0.981
Your Current Organism:
Poecilia reticulata
NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy
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