klhdc10 protein (Poecilia reticulata) - STRING interaction network

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second shell of interactors

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Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Score

klhdc10

Kelch domain containing 10. (387 aa)

Predicted Functional Partners:

pole2

0.479

drg1

0.476

nudt12

0.465

clg6hxorf56

0.461

LOC103461037

0.452

clg6h15orf40

0.448

cs

0.448

skp1

0.431

drg2

0.414

vps53

0.409

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC103461037	clg6h15orf40	ENSPREP00000019992	ENSPREP00000029789	RAN binding protein 2.	Uncharacterized protein.	0.499
LOC103461037	clg6hxorf56	ENSPREP00000019992	ENSPREP00000001402	RAN binding protein 2.	Zgc:103697.	0.669
LOC103461037	cs	ENSPREP00000019992	ENSPREP00000033337	RAN binding protein 2.	Citrate synthase; Belongs to the citrate synthase family.	0.540
LOC103461037	drg1	ENSPREP00000019992	ENSPREP00000015318	RAN binding protein 2.	Developmentally regulated GTP binding protein 1.	0.526
LOC103461037	klhdc10	ENSPREP00000019992	ENSPREP00000005779	RAN binding protein 2.	Kelch domain containing 10.	0.452
LOC103461037	pole2	ENSPREP00000019992	ENSPREP00000007160	RAN binding protein 2.	DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family.	0.559
LOC103461037	vps53	ENSPREP00000019992	ENSPREP00000031529	RAN binding protein 2.	VPS53 subunit of GARP complex.	0.662
clg6h15orf40	LOC103461037	ENSPREP00000029789	ENSPREP00000019992	Uncharacterized protein.	RAN binding protein 2.	0.499
clg6h15orf40	cs	ENSPREP00000029789	ENSPREP00000033337	Uncharacterized protein.	Citrate synthase; Belongs to the citrate synthase family.	0.836
clg6h15orf40	drg1	ENSPREP00000029789	ENSPREP00000015318	Uncharacterized protein.	Developmentally regulated GTP binding protein 1.	0.836
clg6h15orf40	drg2	ENSPREP00000029789	ENSPREP00000029433	Uncharacterized protein.	Developmentally regulated GTP binding protein 2.	0.710
clg6h15orf40	klhdc10	ENSPREP00000029789	ENSPREP00000005779	Uncharacterized protein.	Kelch domain containing 10.	0.448
clg6h15orf40	pole2	ENSPREP00000029789	ENSPREP00000007160	Uncharacterized protein.	DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family.	0.836
clg6hxorf56	LOC103461037	ENSPREP00000001402	ENSPREP00000019992	Zgc:103697.	RAN binding protein 2.	0.669
clg6hxorf56	cs	ENSPREP00000001402	ENSPREP00000033337	Zgc:103697.	Citrate synthase; Belongs to the citrate synthase family.	0.836
clg6hxorf56	drg1	ENSPREP00000001402	ENSPREP00000015318	Zgc:103697.	Developmentally regulated GTP binding protein 1.	0.836
clg6hxorf56	drg2	ENSPREP00000001402	ENSPREP00000029433	Zgc:103697.	Developmentally regulated GTP binding protein 2.	0.710
clg6hxorf56	klhdc10	ENSPREP00000001402	ENSPREP00000005779	Zgc:103697.	Kelch domain containing 10.	0.461
clg6hxorf56	pole2	ENSPREP00000001402	ENSPREP00000007160	Zgc:103697.	DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family.	0.836
cs	LOC103461037	ENSPREP00000033337	ENSPREP00000019992	Citrate synthase; Belongs to the citrate synthase family.	RAN binding protein 2.	0.540

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

45

average node degree:

8.18

avg. local clustering coefficient:

0.849

expected number of edges:

11

PPI enrichment p-value:

1.04e-14

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0007165

Signal transduction

11 of 41

1.98

6.18

1.06e-18

GO:0000160

Phosphorelay signal transduction system

10 of 34

2.02

6.02

4.17e-17

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000155

Phosphorelay sensor kinase activity

8 of 13

2.34

6.34

1.92e-14

GO:0016772

Transferase activity, transferring phosphorus-containing groups

9 of 133

1.38

2.28

4.31e-10

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016021

Integral component of membrane

9 of 760

0.62

0.48

0.0023

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2926

Two-component regulatory system, and Histidine kinase domain

10 of 23

2.18

7.21

1.41e-18

CL:2928

Two-component regulatory system, and Histidine kinase domain

9 of 18

2.25

6.93

6.92e-17

CL:2931

Two-component regulatory system, and PAS domain

8 of 12

2.37

6.82

1.80e-15

CL:2923

Phosphorelay signal transduction system, and P-type ion transporter activity

11 of 35

2.04

6.74

1.59e-19

CL:2933

Histidine kinase domain, and Transcriptional regulatory protein, C terminal

3 of 5

2.32

2.12

9.31e-05

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

aka02020

Two-component system

4 of 79

1.25

0.87

0.0063

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0418

Kinase

9 of 67

1.67

3.58

2.78e-12

KW-0902

Two-component regulatory system

4 of 14

2.0

2.46

7.00e-06

KW-0067

ATP-binding

6 of 232

0.96

0.81

0.00089

KW-0597

Phosphoprotein

2 of 22

1.51

0.67

0.0435

KW-1133

Transmembrane helix

8 of 684

0.61

0.47

0.0033

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR005467

Histidine kinase domain

9 of 11

2.46

7.81

2.22e-17

IPR036890

Histidine kinase/HSP90-like ATPase superfamily

9 of 12

2.42

7.7

2.22e-17

IPR003594

Histidine kinase/HSP90-like ATPase

9 of 12

2.42

7.7

2.22e-17

IPR036097

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain superfamily

8 of 11

2.41

6.82

3.22e-15

IPR003661

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain

8 of 11

2.41

6.82

3.22e-15

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00387

Histidine kinase-like ATPases

9 of 11

2.46

8.28

1.41e-18

SM00388

His Kinase A (phosphoacceptor) domain

8 of 11

2.41

7.18

4.08e-16

SM00304

HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain

4 of 4

2.55

3.75

6.79e-08

SM00091

PAS domain

2 of 3

2.37

1.52

0.0015

SM00862

Transcriptional regulatory protein, C terminal

2 of 12

1.77

0.99

0.0109

(more ...)

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