node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
LOC103476593 | MCM7 | ENSPREP00000005951 | ENSPREP00000020776 | Minichromosome maintenance 8 homologous recombination repair factor; Belongs to the MCM family. | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | 0.971 |
LOC103476593 | Mcm5 | ENSPREP00000005951 | ENSPREP00000022230 | Minichromosome maintenance 8 homologous recombination repair factor; Belongs to the MCM family. | Uncharacterized protein. | 0.989 |
LOC103476593 | cdc45 | ENSPREP00000005951 | ENSPREP00000017327 | Minichromosome maintenance 8 homologous recombination repair factor; Belongs to the MCM family. | CDC45 cell division cycle 45 homolog (S. cerevisiae). | 0.979 |
LOC103476593 | cdc6 | ENSPREP00000005951 | ENSPREP00000032222 | Minichromosome maintenance 8 homologous recombination repair factor; Belongs to the MCM family. | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | 0.991 |
LOC103476593 | cdt1 | ENSPREP00000005951 | ENSPREP00000011428 | Minichromosome maintenance 8 homologous recombination repair factor; Belongs to the MCM family. | Chromatin licensing and DNA replication factor 1. | 0.983 |
LOC103476593 | mcm10 | ENSPREP00000005951 | ENSPREP00000023376 | Minichromosome maintenance 8 homologous recombination repair factor; Belongs to the MCM family. | Minichromosome maintenance 10 replication initiation factor. | 0.978 |
LOC103476593 | mcm3 | ENSPREP00000005951 | ENSPREP00000028616 | Minichromosome maintenance 8 homologous recombination repair factor; Belongs to the MCM family. | DNA helicase; Belongs to the MCM family. | 0.990 |
LOC103476593 | mcm4 | ENSPREP00000005951 | ENSPREP00000012626 | Minichromosome maintenance 8 homologous recombination repair factor; Belongs to the MCM family. | DNA helicase; Belongs to the MCM family. | 0.990 |
LOC103476593 | orc1 | ENSPREP00000005951 | ENSPREP00000001890 | Minichromosome maintenance 8 homologous recombination repair factor; Belongs to the MCM family. | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. | 0.971 |
LOC103476593 | orc2 | ENSPREP00000005951 | ENSPREP00000031604 | Minichromosome maintenance 8 homologous recombination repair factor; Belongs to the MCM family. | Origin recognition complex, subunit 2. | 0.984 |
MCM7 | LOC103476593 | ENSPREP00000020776 | ENSPREP00000005951 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | Minichromosome maintenance 8 homologous recombination repair factor; Belongs to the MCM family. | 0.971 |
MCM7 | Mcm5 | ENSPREP00000020776 | ENSPREP00000022230 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | Uncharacterized protein. | 0.996 |
MCM7 | cdc45 | ENSPREP00000020776 | ENSPREP00000017327 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | CDC45 cell division cycle 45 homolog (S. cerevisiae). | 0.987 |
MCM7 | cdc6 | ENSPREP00000020776 | ENSPREP00000032222 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | 0.990 |
MCM7 | cdt1 | ENSPREP00000020776 | ENSPREP00000011428 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | Chromatin licensing and DNA replication factor 1. | 0.994 |
MCM7 | mcm10 | ENSPREP00000020776 | ENSPREP00000023376 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | Minichromosome maintenance 10 replication initiation factor. | 0.989 |
MCM7 | mcm3 | ENSPREP00000020776 | ENSPREP00000028616 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | DNA helicase; Belongs to the MCM family. | 0.998 |
MCM7 | mcm4 | ENSPREP00000020776 | ENSPREP00000012626 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | DNA helicase; Belongs to the MCM family. | 0.997 |
MCM7 | orc1 | ENSPREP00000020776 | ENSPREP00000001890 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. | 0.988 |
MCM7 | orc2 | ENSPREP00000020776 | ENSPREP00000031604 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | Origin recognition complex, subunit 2. | 0.969 |