LOC103465726 protein (Poecilia reticulata) - STRING interaction network

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Known Interactions

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Predicted Interactions

gene neighborhood

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gene co-occurrence

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Score

LOC103465726

Asp_protease domain-containing protein. (272 aa)

Predicted Functional Partners:

tbc1d30

0.676

rps27a

0.670

Rad23a

0.598

RAD23B

0.598

rnf182

0.544

psmd2

0.541

ubl7

0.486

ubqln4

0.486

UBQLN1

0.486

uba52

0.480

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC103465726	RAD23B	ENSPREP00000006000	ENSPREP00000024975	Asp_protease domain-containing protein.	RAD23 homolog B, nucleotide excision repair protein.	0.598
LOC103465726	Rad23a	ENSPREP00000006000	ENSPREP00000019043	Asp_protease domain-containing protein.	Ubiquitin-like domain-containing protein.	0.598
LOC103465726	UBQLN1	ENSPREP00000006000	ENSPREP00000027890	Asp_protease domain-containing protein.	Ubiquilin 1.	0.486
LOC103465726	psmd2	ENSPREP00000006000	ENSPREP00000015350	Asp_protease domain-containing protein.	26S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family.	0.541
LOC103465726	rnf182	ENSPREP00000006000	ENSPREP00000030307	Asp_protease domain-containing protein.	Ring finger protein 182.	0.544
LOC103465726	rps27a	ENSPREP00000006000	ENSPREP00000018427	Asp_protease domain-containing protein.	Ribosomal protein S27a.	0.670
LOC103465726	tbc1d30	ENSPREP00000006000	ENSPREP00000027154	Asp_protease domain-containing protein.	TBC1 domain family, member 30.	0.676
LOC103465726	uba52	ENSPREP00000006000	ENSPREP00000016516	Asp_protease domain-containing protein.	Ubiquitin A-52 residue ribosomal protein fusion product 1.	0.480
LOC103465726	ubl7	ENSPREP00000006000	ENSPREP00000008628	Asp_protease domain-containing protein.	Ubiquitin-like 7b (bone marrow stromal cell-derived).	0.486
LOC103465726	ubqln4	ENSPREP00000006000	ENSPREP00000008822	Asp_protease domain-containing protein.	Ubiquilin 4.	0.486
RAD23B	LOC103465726	ENSPREP00000024975	ENSPREP00000006000	RAD23 homolog B, nucleotide excision repair protein.	Asp_protease domain-containing protein.	0.598
RAD23B	Rad23a	ENSPREP00000024975	ENSPREP00000019043	RAD23 homolog B, nucleotide excision repair protein.	Ubiquitin-like domain-containing protein.	0.915
RAD23B	UBQLN1	ENSPREP00000024975	ENSPREP00000027890	RAD23 homolog B, nucleotide excision repair protein.	Ubiquilin 1.	0.656
RAD23B	psmd2	ENSPREP00000024975	ENSPREP00000015350	RAD23 homolog B, nucleotide excision repair protein.	26S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family.	0.954
RAD23B	rps27a	ENSPREP00000024975	ENSPREP00000018427	RAD23 homolog B, nucleotide excision repair protein.	Ribosomal protein S27a.	0.900
RAD23B	uba52	ENSPREP00000024975	ENSPREP00000016516	RAD23 homolog B, nucleotide excision repair protein.	Ubiquitin A-52 residue ribosomal protein fusion product 1.	0.967
RAD23B	ubl7	ENSPREP00000024975	ENSPREP00000008628	RAD23 homolog B, nucleotide excision repair protein.	Ubiquitin-like 7b (bone marrow stromal cell-derived).	0.656
RAD23B	ubqln4	ENSPREP00000024975	ENSPREP00000008822	RAD23 homolog B, nucleotide excision repair protein.	Ubiquilin 4.	0.877
Rad23a	LOC103465726	ENSPREP00000019043	ENSPREP00000006000	Ubiquitin-like domain-containing protein.	Asp_protease domain-containing protein.	0.598
Rad23a	RAD23B	ENSPREP00000019043	ENSPREP00000024975	Ubiquitin-like domain-containing protein.	RAD23 homolog B, nucleotide excision repair protein.	0.915

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

43

average node degree:

7.82

avg. local clustering coefficient:

0.83

expected number of edges:

11

PPI enrichment p-value:

8.85e-13

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0015288

Porin activity

2 of 5

2.96

1.15

0.0097

GO:0008308

Voltage-gated anion channel activity

2 of 15

2.48

0.85

0.0313

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:32899810

(2020) Screening for the Proteins That Can Interact with Grouper Nervous Necrosis Virus Capsid Protein.

2 of 20

2.36

0.84

0.0325

PMID:27571066

(2016) Sexually Dimorphic Gene Expression Associated with Growth and Reproduction of Tongue Sole (Cynoglossus semilaevis) Revealed by Brain Transcriptome Analysis.

2 of 26

2.25

0.83

0.0325

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:38678

Mixed, incl. Notochord cell development, and AB hydrolase 4, conserved site

2 of 5

2.96

1.0

0.0180

CL:22657

ATP:ADP antiporter activity, and Porin activity

2 of 11

2.62

0.84

0.0335

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

pret04216

Ferroptosis

2 of 46

2.0

0.82

0.0319

Tissue Expression (TISSUES)

tissue

description

count in network

strength

signal

false discovery rate

BTO:0001630

Right ventricle

2 of 179

1.41

0.76

0.0242

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01459

Eukaryotic porin

2 of 8

2.76

1.0

0.0176

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR001925

Porin, eukaryotic type

2 of 5

2.96

0.91

0.0256

IPR027246

Eukaryotic porin/Tom40

2 of 8

2.76

0.89

0.0274

IPR023614

Porin domain superfamily

2 of 8

2.76

0.89

0.0274

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