nr2c1 protein (Poecilia reticulata) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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Score

nr2c1

Nuclear receptor subfamily 2, group C, member 1. (565 aa)

Predicted Functional Partners:

ncor2

0.632

ncor1

0.632

JAZF1

0.611

LOC103472509

0.611

TADA1

0.583

nrip1

0.558

dclre1b

0.514

fkbp9

0.513

zbtb10

0.501

znf276

0.501

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
JAZF1	nr2c1	ENSPREP00000002013	ENSPREP00000006105	JAZF zinc finger 1b.	Nuclear receptor subfamily 2, group C, member 1.	0.611
LOC103472509	nr2c1	ENSPREP00000031858	ENSPREP00000006105	JAZF zinc finger 1.	Nuclear receptor subfamily 2, group C, member 1.	0.611
TADA1	nr2c1	ENSPREP00000005904	ENSPREP00000006105	Transcriptional adaptor 1.	Nuclear receptor subfamily 2, group C, member 1.	0.583
dclre1b	nr2c1	ENSPREP00000033608	ENSPREP00000006105	DNA cross-link repair 1B.	Nuclear receptor subfamily 2, group C, member 1.	0.514
dclre1b	zbtb10	ENSPREP00000033608	ENSPREP00000011821	DNA cross-link repair 1B.	Zinc finger and BTB domain containing 10.	0.557
dclre1b	znf276	ENSPREP00000033608	ENSPREP00000031022	DNA cross-link repair 1B.	Zinc finger protein 276.	0.557
fkbp9	nr2c1	ENSPREP00000008377	ENSPREP00000006105	Peptidylprolyl isomerase.	Nuclear receptor subfamily 2, group C, member 1.	0.513
ncor1	nr2c1	ENSPREP00000009626	ENSPREP00000006105	Nuclear receptor corepressor 1.	Nuclear receptor subfamily 2, group C, member 1.	0.632
ncor2	nr2c1	ENSPREP00000001887	ENSPREP00000006105	Nuclear receptor corepressor 2.	Nuclear receptor subfamily 2, group C, member 1.	0.632
nr2c1	JAZF1	ENSPREP00000006105	ENSPREP00000002013	Nuclear receptor subfamily 2, group C, member 1.	JAZF zinc finger 1b.	0.611
nr2c1	LOC103472509	ENSPREP00000006105	ENSPREP00000031858	Nuclear receptor subfamily 2, group C, member 1.	JAZF zinc finger 1.	0.611
nr2c1	TADA1	ENSPREP00000006105	ENSPREP00000005904	Nuclear receptor subfamily 2, group C, member 1.	Transcriptional adaptor 1.	0.583
nr2c1	dclre1b	ENSPREP00000006105	ENSPREP00000033608	Nuclear receptor subfamily 2, group C, member 1.	DNA cross-link repair 1B.	0.514
nr2c1	fkbp9	ENSPREP00000006105	ENSPREP00000008377	Nuclear receptor subfamily 2, group C, member 1.	Peptidylprolyl isomerase.	0.513
nr2c1	ncor1	ENSPREP00000006105	ENSPREP00000009626	Nuclear receptor subfamily 2, group C, member 1.	Nuclear receptor corepressor 1.	0.632
nr2c1	ncor2	ENSPREP00000006105	ENSPREP00000001887	Nuclear receptor subfamily 2, group C, member 1.	Nuclear receptor corepressor 2.	0.632
nr2c1	nrip1	ENSPREP00000006105	ENSPREP00000015830	Nuclear receptor subfamily 2, group C, member 1.	Nuclear receptor interacting protein 1b.	0.558
nr2c1	zbtb10	ENSPREP00000006105	ENSPREP00000011821	Nuclear receptor subfamily 2, group C, member 1.	Zinc finger and BTB domain containing 10.	0.501
nr2c1	znf276	ENSPREP00000006105	ENSPREP00000031022	Nuclear receptor subfamily 2, group C, member 1.	Zinc finger protein 276.	0.501
nrip1	nr2c1	ENSPREP00000015830	ENSPREP00000006105	Nuclear receptor interacting protein 1b.	Nuclear receptor subfamily 2, group C, member 1.	0.558

page 1 of 2

Network Stats

number of nodes:

10

number of edges:

21

average node degree:

4.2

avg. local clustering coefficient:

0.873

expected number of edges:

9

PPI enrichment p-value:

0.000652

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0040019

Positive regulation of embryonic development

2 of 6

2.88

0.81

0.0391

GO:0045039

Protein insertion into mitochondrial inner membrane

2 of 8

2.76

0.8

0.0391

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005743

Mitochondrial inner membrane

4 of 419

1.34

0.72

0.0279

GO:0098798

Mitochondrial protein-containing complex

3 of 267

1.41

0.65

0.0463

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:6513

Mixed, incl. Tim10-like, and Mitochondrial intermembrane space import and assembly protein 40

4 of 17

2.73

3.46

5.49e-07

CL:6519

TIM22 mitochondrial import inner membrane insertion complex, and Tim10-like

3 of 5

3.14

2.98

5.61e-06

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1268020

Mitochondrial protein import

3 of 47

2.16

1.47

0.0019

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0042719

Mitochondrial intermembrane space protein transporter complex

2 of 5

2.96

1.46

0.0028

GOCC:0098798

Mitochondrial protein complex

4 of 228

1.6

1.2

0.0028

GOCC:0005740

Mitochondrial envelope

4 of 383

1.38

1.05

0.0034

GOCC:0031967

Organelle envelope

5 of 547

1.32

1.03

0.0028

GOCC:0071013

Catalytic step 2 spliceosome

2 of 37

2.09

0.92

0.0215

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0811

Translocation

2 of 20

2.36

1.05

0.0132

KW-0496

Mitochondrion

3 of 160

1.63

0.94

0.0132

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF10312

Conserved mid region of cactin

2 of 2

3.36

1.51

0.0023

PF04621

PEA3 subfamily ETS-domain transcription factor N terminal domain

2 of 4

3.06

1.45

0.0029

PF02953

Tim10/DDP family zinc finger

2 of 6

2.88

1.39

0.0036

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR019134

Splicing factor Cactin, C-terminal

2 of 2

3.36

1.23

0.0073

IPR018816

Splicing factor cactin, central domain

2 of 2

3.36

1.23

0.0073

IPR006715

PEA3-type ETS-domain transcription factor, N-terminal

2 of 4

3.06

1.22

0.0073

IPR035427

Tim10-like domain superfamily

2 of 6

2.88

1.18

0.0085

IPR004217

Tim10-like

2 of 6

2.88

1.18

0.0085

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM01050

Cactus-binding C-terminus of cactin protein

2 of 3

3.18

1.65

0.0013

SM00413

Erythroblast transformation specific domain

2 of 32

2.15

0.8

0.0372

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