STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
LOC103478999MHD domain-containing protein. (895 aa)    
Predicted Functional Partners:
ENSPREP00000015831
Uncharacterized protein.
   
 0.904
ENSPREP00000015870
Uncharacterized protein.
   
 0.904
ENSPREP00000015917
EH domain-containing protein.
   
 0.904
itsn2
Intersectin 2a.
   
 0.904
ap2s1
AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.
    
 0.846
ap2m1
AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...]
   
 0.819
ENSPREP00000007450
Uncharacterized protein.
   
 0.814
ENSPREP00000008107
Intersectin 1 (SH3 domain protein).
   
 0.814
ENSPREP00000030224
PID domain-containing protein.
   
 0.770
LOC103479878
Epidermal growth factor receptor pathway substrate 15 like 1.
   
 0.747
Your Current Organism:
Poecilia reticulata
NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.