ENSPREP00000006378 protein (Poecilia reticulata)

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

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Score

ENSPREP00000006378

Thioredoxin domain-containing protein. (133 aa)

Predicted Functional Partners:

txnip

0.916

prdx5

0.896

LOC103465416

0.869

txnrd2

0.832

msra

0.806

LOC103458858

0.806

PRDX2

0.776

LOC103479005

0.776

prdx4

0.758

prdx3

0.756

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000006378	LOC103458858	ENSPREP00000006378	ENSPREP00000028737	Thioredoxin domain-containing protein.	Si:ch1073-358c10.1.	0.806
ENSPREP00000006378	LOC103465416	ENSPREP00000006378	ENSPREP00000026356	Thioredoxin domain-containing protein.	Thioredoxin reductase 3.	0.869
ENSPREP00000006378	LOC103479005	ENSPREP00000006378	ENSPREP00000006508	Thioredoxin domain-containing protein.	Peroxiredoxin 1.	0.776
ENSPREP00000006378	PRDX2	ENSPREP00000006378	ENSPREP00000000701	Thioredoxin domain-containing protein.	Peroxiredoxin 2.	0.776
ENSPREP00000006378	msra	ENSPREP00000006378	ENSPREP00000026949	Thioredoxin domain-containing protein.	Methionine sulfoxide reductase A.	0.806
ENSPREP00000006378	prdx3	ENSPREP00000006378	ENSPREP00000002709	Thioredoxin domain-containing protein.	Peroxiredoxin 3.	0.756
ENSPREP00000006378	prdx4	ENSPREP00000006378	ENSPREP00000029598	Thioredoxin domain-containing protein.	Peroxiredoxin 4.	0.758
ENSPREP00000006378	prdx5	ENSPREP00000006378	ENSPREP00000017624	Thioredoxin domain-containing protein.	Peroxiredoxin; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. Prx5 subfamily.	0.896
ENSPREP00000006378	txnip	ENSPREP00000006378	ENSPREP00000029812	Thioredoxin domain-containing protein.	Thioredoxin interacting protein.	0.916
ENSPREP00000006378	txnrd2	ENSPREP00000006378	ENSPREP00000027510	Thioredoxin domain-containing protein.	Thioredoxin reductase 2, tandem duplicate 1.	0.832
LOC103458858	ENSPREP00000006378	ENSPREP00000028737	ENSPREP00000006378	Si:ch1073-358c10.1.	Thioredoxin domain-containing protein.	0.806
LOC103465416	ENSPREP00000006378	ENSPREP00000026356	ENSPREP00000006378	Thioredoxin reductase 3.	Thioredoxin domain-containing protein.	0.869
LOC103465416	LOC103479005	ENSPREP00000026356	ENSPREP00000006508	Thioredoxin reductase 3.	Peroxiredoxin 1.	0.441
LOC103465416	PRDX2	ENSPREP00000026356	ENSPREP00000000701	Thioredoxin reductase 3.	Peroxiredoxin 2.	0.441
LOC103465416	prdx3	ENSPREP00000026356	ENSPREP00000002709	Thioredoxin reductase 3.	Peroxiredoxin 3.	0.501
LOC103465416	prdx4	ENSPREP00000026356	ENSPREP00000029598	Thioredoxin reductase 3.	Peroxiredoxin 4.	0.502
LOC103465416	prdx5	ENSPREP00000026356	ENSPREP00000017624	Thioredoxin reductase 3.	Peroxiredoxin; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. Prx5 subfamily.	0.795
LOC103465416	txnrd2	ENSPREP00000026356	ENSPREP00000027510	Thioredoxin reductase 3.	Thioredoxin reductase 2, tandem duplicate 1.	0.909
LOC103479005	ENSPREP00000006378	ENSPREP00000006508	ENSPREP00000006378	Peroxiredoxin 1.	Thioredoxin domain-containing protein.	0.776
LOC103479005	LOC103465416	ENSPREP00000006508	ENSPREP00000026356	Peroxiredoxin 1.	Thioredoxin reductase 3.	0.441

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

20

average node degree:

3.64

avg. local clustering coefficient:

0.872

expected number of edges:

10

PPI enrichment p-value:

0.00363

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0044772

Mitotic cell cycle phase transition

7 of 105

2.14

4.55

7.76e-11

GO:0000079

Regulation of cyclin-dependent protein serine/threonine kinase activity

6 of 72

2.24

4.33

7.98e-10

GO:1903047

Mitotic cell cycle process

9 of 402

1.67

3.29

7.76e-11

GO:0051301

Cell division

7 of 393

1.57

2.39

1.20e-07

GO:0051726

Regulation of cell cycle

8 of 702

1.37

1.98

1.14e-07

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016538

Cyclin-dependent protein serine/threonine kinase regulator activity

5 of 52

2.3

3.51

9.84e-08

GO:0003688

DNA replication origin binding

2 of 13

2.5

1.06

0.0118

GO:0030234

Enzyme regulator activity

6 of 1134

1.04

0.78

0.0038

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000307

Cyclin-dependent protein kinase holoenzyme complex

5 of 40

2.41

4.0

1.35e-08

GO:0097124

Cyclin A2-CDK2 complex

2 of 3

3.14

1.81

0.00053

GO:0005813

Centrosome

4 of 419

1.3

0.9

0.0062

GO:0015630

Microtubule cytoskeleton

5 of 1092

0.98

0.64

0.0128

GO:0005634

Nucleus

10 of 6688

0.49

0.37

0.0062

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:37288606

(2023) Cytoplasmic Polyadenylation Is an Ancestral Hallmark of Early Development in Animals.

4 of 15

2.74

3.77

9.20e-08

PMID:24742317

(2014) Comparative analysis of the gonadal transcriptomes of the all-female species Poecilia formosa and its maternal ancestor Poecilia mexicana.

2 of 10

2.62

1.23

0.0057

PMID:24886435

(2014) Transcriptome assemblies for studying sex-biased gene expression in the guppy, Poecilia reticulata.

2 of 26

2.2

0.9

0.0216

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:7892

Cyclin-dependent protein serine/threonine kinase regulator activity, and Cyclin-dependent protein kinase activity

6 of 49

2.41

4.71

3.34e-10

CL:7953

Mixed, incl. G2/M DNA replication checkpoint, and Positive regulation of meiotic cell cycle phase transition

4 of 11

2.88

4.08

2.82e-08

CL:7890

Mixed, incl. Mitotic cell cycle phase transition, and Mitotic sister chromatid segregation

7 of 163

1.95

3.79

8.91e-10

CL:7246

DNA replication origin binding, and MCM domain

3 of 14

2.65

2.43

3.11e-05

CL:7900

G2 Phase, and Cyclin-dependent kinase inhibitor

2 of 5

2.92

1.53

0.0017

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

pret04110

Cell cycle

7 of 120

2.08

4.77

7.42e-12

pret04914

Progesterone-mediated oocyte maturation

4 of 88

1.98

2.45

6.58e-06

pret04218

Cellular senescence

3 of 178

1.54

1.09

0.0042

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-69273

Cyclin A/B1/B2 associated events during G2/M transition

7 of 36

2.61

6.96

1.36e-14

MAP-69478

G2/M DNA replication checkpoint

4 of 7

3.07

4.74

1.98e-09

MAP-69481

G2/M Checkpoints

8 of 189

1.94

4.59

1.41e-12

MAP-69620

Cell Cycle Checkpoints

10 of 344

1.78

4.42

1.26e-14

MAP-2995383

Initiation of Nuclear Envelope (NE) Reformation

4 of 19

2.64

3.94

3.54e-08

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0097124

Cyclin A2-CDK2 complex

3 of 4

3.19

2.95

4.43e-06

GOCC:0000307

Cyclin-dependent protein kinase holoenzyme complex

4 of 37

2.35

2.77

4.43e-06

GOCC:0000808

Origin recognition complex

2 of 7

2.77

1.48

0.0020

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0195

Cyclin

5 of 33

2.5

4.51

1.48e-09

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR004367

Cyclin, C-terminal domain

5 of 16

2.81

4.75

1.28e-09

IPR039361

Cyclin

5 of 20

2.72

4.64

1.66e-09

IPR006671

Cyclin, N-terminal

5 of 35

2.47

4.04

1.37e-08

IPR013763

Cyclin-like domain

5 of 37

2.45

4.02

1.37e-08

IPR036915

Cyclin-like superfamily

5 of 47

2.34

3.76

3.24e-08

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00385

Domain present in cyclins, TFIIB and Retinoblastoma

5 of 41

2.4

4.06

9.36e-09

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