Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-occurrence
Co-expression
Experiments
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[Homology]
Score
nuak2NUAK family, SNF1-like kinase, 2. (606 aa)    
Predicted Functional Partners:
stk11
Serine/threonine kinase 11; Belongs to the protein kinase superfamily.
    
 0.692
LOC103478912
Ubiquitin specific peptidase 9; Belongs to the peptidase C19 family.
    
 
 0.635
gpr176
G protein-coupled receptor 176.
      
 0.591
tp53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
    
 0.562
fbxw11
F-box and WD repeat domain containing 11a.
    
   0.503
pla2g4c
Zgc:101699.
      
 0.449
lmod1
Leiomodin 1b (smooth muscle).
   
  
 0.425
itga2
Integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor), tandem duplicate 2; Belongs to the integrin alpha chain family.
   
  
 0.422
ric8b
RIC8 guanine nucleotide exchange factor B.
      
 0.407
ccdc171
Uncharacterized protein.
      
 0.406
Your Current Organism:
Poecilia reticulata
NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy
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