atrx protein (Poecilia reticulata) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

atrx

ATRX chromatin remodeler. (2188 aa)

Predicted Functional Partners:

rad51

0.995

supt16h

0.944

rad50

0.931

nbn

0.931

mre11

0.930

ssrp1

0.929

mecp2

0.926

rad52

0.920

tp53

0.913

smc5

0.872

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
atrx	mecp2	ENSPREP00000006575	ENSPREP00000018569	ATRX chromatin remodeler.	Methyl CpG binding protein 2.	0.926
atrx	mre11	ENSPREP00000006575	ENSPREP00000033509	ATRX chromatin remodeler.	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.930
atrx	nbn	ENSPREP00000006575	ENSPREP00000024347	ATRX chromatin remodeler.	Nibrin.	0.931
atrx	rad50	ENSPREP00000006575	ENSPREP00000008829	ATRX chromatin remodeler.	RAD50 homolog, double strand break repair protein.	0.931
atrx	rad51	ENSPREP00000006575	ENSPREP00000001621	ATRX chromatin remodeler.	RAD51 recombinase.	0.995
atrx	rad52	ENSPREP00000006575	ENSPREP00000023884	ATRX chromatin remodeler.	RAD52 homolog, DNA repair protein.	0.920
atrx	smc5	ENSPREP00000006575	ENSPREP00000033520	ATRX chromatin remodeler.	Structural maintenance of chromosomes 5.	0.872
atrx	ssrp1	ENSPREP00000006575	ENSPREP00000025982	ATRX chromatin remodeler.	FACT complex subunit SSRP1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...]	0.929
atrx	supt16h	ENSPREP00000006575	ENSPREP00000013238	ATRX chromatin remodeler.	SPT16 homolog, facilitates chromatin remodeling subunit.	0.944
atrx	tp53	ENSPREP00000006575	ENSPREP00000019676	ATRX chromatin remodeler.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.913
mecp2	atrx	ENSPREP00000018569	ENSPREP00000006575	Methyl CpG binding protein 2.	ATRX chromatin remodeler.	0.926
mre11	atrx	ENSPREP00000033509	ENSPREP00000006575	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	ATRX chromatin remodeler.	0.930
mre11	nbn	ENSPREP00000033509	ENSPREP00000024347	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	Nibrin.	0.999
mre11	rad50	ENSPREP00000033509	ENSPREP00000008829	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	RAD50 homolog, double strand break repair protein.	0.999
mre11	rad51	ENSPREP00000033509	ENSPREP00000001621	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	RAD51 recombinase.	0.984
mre11	rad52	ENSPREP00000033509	ENSPREP00000023884	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	RAD52 homolog, DNA repair protein.	0.952
mre11	smc5	ENSPREP00000033509	ENSPREP00000033520	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	Structural maintenance of chromosomes 5.	0.671
mre11	tp53	ENSPREP00000033509	ENSPREP00000019676	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.985
nbn	atrx	ENSPREP00000024347	ENSPREP00000006575	Nibrin.	ATRX chromatin remodeler.	0.931
nbn	mre11	ENSPREP00000024347	ENSPREP00000033509	Nibrin.	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.999