LOC103460623 protein (Poecilia reticulata) - STRING interaction network

Nodes:

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second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Cooccurrence

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Score

LOC103460623

Prothymosin alpha b. (105 aa)

Predicted Functional Partners:

rps3

0.769

rpl15

0.700

ENSPREP00000026680

0.652

rpl13

0.647

ENSPREP00000002096

0.640

klhl18

0.640

LOC103458467

0.640

keap1

0.640

klhl17

0.640

rpl6

0.635

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000002096	LOC103460623	ENSPREP00000002096	ENSPREP00000006652	Uncharacterized protein.	Prothymosin alpha b.	0.640
ENSPREP00000026680	LOC103460623	ENSPREP00000026680	ENSPREP00000006652	H1 histone family, member 0.	Prothymosin alpha b.	0.652
LOC103458467	LOC103460623	ENSPREP00000014955	ENSPREP00000006652	Kelch-like ECH-associated protein 1a.	Prothymosin alpha b.	0.640
LOC103458467	keap1	ENSPREP00000014955	ENSPREP00000020487	Kelch-like ECH-associated protein 1a.	Kelch-like ECH-associated protein 1b.	0.903
LOC103460623	ENSPREP00000002096	ENSPREP00000006652	ENSPREP00000002096	Prothymosin alpha b.	Uncharacterized protein.	0.640
LOC103460623	ENSPREP00000026680	ENSPREP00000006652	ENSPREP00000026680	Prothymosin alpha b.	H1 histone family, member 0.	0.652
LOC103460623	LOC103458467	ENSPREP00000006652	ENSPREP00000014955	Prothymosin alpha b.	Kelch-like ECH-associated protein 1a.	0.640
LOC103460623	keap1	ENSPREP00000006652	ENSPREP00000020487	Prothymosin alpha b.	Kelch-like ECH-associated protein 1b.	0.640
LOC103460623	klhl17	ENSPREP00000006652	ENSPREP00000022681	Prothymosin alpha b.	Kelch-like family member 17.	0.640
LOC103460623	klhl18	ENSPREP00000006652	ENSPREP00000013268	Prothymosin alpha b.	Kelch-like family member 18.	0.640
LOC103460623	rpl13	ENSPREP00000006652	ENSPREP00000034247	Prothymosin alpha b.	60S ribosomal protein L13; Belongs to the eukaryotic ribosomal protein eL13 family.	0.647
LOC103460623	rpl15	ENSPREP00000006652	ENSPREP00000020280	Prothymosin alpha b.	Ribosomal protein L15; Belongs to the eukaryotic ribosomal protein eL15 family.	0.700
LOC103460623	rpl6	ENSPREP00000006652	ENSPREP00000016862	Prothymosin alpha b.	Ribosomal protein L6.	0.635
LOC103460623	rps3	ENSPREP00000006652	ENSPREP00000025968	Prothymosin alpha b.	Ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family.	0.769
keap1	LOC103458467	ENSPREP00000020487	ENSPREP00000014955	Kelch-like ECH-associated protein 1b.	Kelch-like ECH-associated protein 1a.	0.903
keap1	LOC103460623	ENSPREP00000020487	ENSPREP00000006652	Kelch-like ECH-associated protein 1b.	Prothymosin alpha b.	0.640
klhl17	LOC103460623	ENSPREP00000022681	ENSPREP00000006652	Kelch-like family member 17.	Prothymosin alpha b.	0.640
klhl18	LOC103460623	ENSPREP00000013268	ENSPREP00000006652	Kelch-like family member 18.	Prothymosin alpha b.	0.640
rpl13	LOC103460623	ENSPREP00000034247	ENSPREP00000006652	60S ribosomal protein L13; Belongs to the eukaryotic ribosomal protein eL13 family.	Prothymosin alpha b.	0.647
rpl13	rpl15	ENSPREP00000034247	ENSPREP00000020280	60S ribosomal protein L13; Belongs to the eukaryotic ribosomal protein eL13 family.	Ribosomal protein L15; Belongs to the eukaryotic ribosomal protein eL15 family.	0.999

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

50

average node degree:

9.09

avg. local clustering coefficient:

0.894

expected number of edges:

10

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0007062

Sister chromatid cohesion

9 of 40

2.67

9.23

1.94e-19

GO:0007064

Mitotic sister chromatid cohesion

8 of 24

2.84

8.98

3.79e-18

GO:0071168

Protein localization to chromatin

6 of 11

3.05

7.22

3.71e-14

GO:0071921

Cohesin loading

4 of 4

3.32

4.95

1.03e-09

GO:0000278

Mitotic cell cycle

10 of 481

1.64

3.61

2.08e-13

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0061775

Cohesin loading activity

2 of 2

3.32

1.37

0.0034

GO:0003682

Chromatin binding

4 of 420

1.3

0.61

0.0465

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0090694

Scc2-Scc4 cohesin loading complex

4 of 4

3.32

4.73

2.55e-09

GO:0000794

Condensed nuclear chromosome

5 of 49

2.33

3.95

1.16e-08

GO:0000798

Nuclear cohesin complex

3 of 5

3.1

3.26

1.17e-06

GO:0000795

Synaptonemal complex

3 of 22

2.45

2.38e-05

GO:0034990

Nuclear mitotic cohesin complex

2 of 2

3.32

2.17

0.00012

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:7532

Cohesin Loading onto Chromatin

11 of 20

3.06

14.81

1.89e-29

CL:7535

Cohesin Loading onto Chromatin

8 of 15

3.04

10.11

7.26e-20

CL:7537

Establishment of Sister Chromatid Cohesion

4 of 6

3.14

4.45

7.59e-09

CL:7552

Cohesin complex

2 of 5

2.92

1.3

0.0044

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-2470946

Cohesin Loading onto Chromatin

11 of 20

3.06

15.04

6.30e-30

MAP-68884

Mitotic Telophase/Cytokinesis

11 of 23

3.0

14.76

1.06e-29

MAP-2468052

Establishment of Sister Chromatid Cohesion

7 of 19

2.88

8.23

1.85e-16

MAP-2500257

Resolution of Sister Chromatid Cohesion

7 of 165

1.95

4.08

9.21e-11

MAP-68886

M Phase

11 of 529

1.64

3.95

4.79e-16

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0032116

SMC loading complex

4 of 4

3.32

4.69

3.10e-09

GOCC:0090694

Scc2-Scc4 cohesin loading complex

3 of 3

3.32

3.31

1.02e-06

GOCC:0000793

Condensed chromosome

5 of 110

1.98

2.77

1.02e-06

GOCC:0008278

Cohesin complex

3 of 14

2.65

2.57

1.72e-05

GOCC:0034990

Nuclear mitotic cohesin complex

2 of 2

3.32

1.94

0.00032

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0131

Cell cycle

2 of 31

2.13

0.77

0.0368

KW-0539

Nucleus

5 of 1189

0.94

0.52

0.0368

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF12830

Sister chromatid cohesion C-terminus

2 of 2

3.32

1.41

0.0029

PF12765

HEAT repeat associated with sister chromatid cohesion

2 of 4

3.02

1.41

0.0029

PF07814

Wings apart-like protein regulation of heterochromatin

2 of 2

3.32

1.41

0.0029

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR033031

Scc2/Nipped-B family

3 of 3

3.32

2.9

5.87e-06

IPR011989

Armadillo-like helical

6 of 228

1.74

2.3

3.38e-06

IPR039874

Wings apart-like protein

2 of 2

3.32

1.48

0.0022

IPR039776

Sister chromatid cohesion protein Pds5

2 of 2

3.32

1.48

0.0022

IPR024986

Sister chromatid cohesion C-terminal domain

2 of 2

3.32

1.48

0.0022

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00968

SMC proteins Flexible Hinge Domain

2 of 7

2.77

1.23

0.0059

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