STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ENSPREP00000006768Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (152 aa)    
Predicted Functional Partners:
LOC103472703
EF-hand domain-containing protein.
    
 
 0.887
ENSPREP00000013954
Uncharacterized protein.
    
 0.810
LOC103477293
Fibroblast growth factor receptor.
    
 0.810
LOC103469672
Fibroblast growth factor receptor.
    
 0.791
fgfr4
Fibroblast growth factor receptor 4.
    
 0.776
LOC103458160
Fibroblast growth factor receptor.
    
 0.776
LOC103473157
Fibroblast growth factor receptor.
    
 0.751
LOC103471859
Fibroblast growth factor binding protein 1b.
    
 0.730
mydgf
Myeloid-derived growth factor.
      
 0.681
fgf17
Fibroblast growth factor; Belongs to the heparin-binding growth factors family.
   
 
 0.635
Your Current Organism:
Poecilia reticulata
NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.