STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
babam2BRISC and BRCA1 A complex member 2. (386 aa)    
Predicted Functional Partners:
abraxas2
Abraxas 2, BRISC complex subunit.
    
 0.999
babam1
BRISC and BRCA1 A complex member 1.
    
 0.999
Brcc3
BRCA1/BRCA2-containing complex, subunit 3.
    
 0.999
brca1
Uncharacterized protein.
    
 0.993
bard1
BRCA1 associated RING domain 1.
   
 0.991
brca2
BRCA2 DNA repair associated.
    
 
 0.947
uimc1
Uncharacterized protein.
    
 0.942
tp53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
    
 0.925
rad51
RAD51 recombinase.
    
 0.890
ENSPREP00000007980
Reverse transcriptase domain-containing protein.
    
 0.880
Your Current Organism:
Poecilia reticulata
NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy
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