Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
SHFSrc homology 2 domain containing F. (471 aa)    
Predicted Functional Partners:
mpv17
Mitochondrial inner membrane protein MPV17; Belongs to the peroxisomal membrane protein PXMP2/4 family.
      
 0.494
crkl
V-crk avian sarcoma virus CT10 oncogene homolog-like.
    
 0.488
crk
CRK proto-oncogene, adaptor protein.
    
 0.488
ENSPREP00000023825
SH2 domain-containing protein.
    
 0.488
flt4
Fms-related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
    
  0.475
LOC103471632
Kinase insert domain receptor like; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
    
  0.475
flt1
Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
    
  0.475
kdr
Kinase insert domain receptor (a type III receptor tyrosine kinase); Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
    
  0.475
LOC103472162
Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
      
 0.472
rock2
Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity.
     
  0.411
Your Current Organism:
Poecilia reticulata
NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy
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