STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pik3c2aPhosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha; Belongs to the PI3/PI4-kinase family. (1712 aa)    
Predicted Functional Partners:
inpp5b
Inositol polyphosphate-5-phosphatase B.
     
 0.953
gak
Cyclin G associated kinase.
    
 0.946
inppl1
Inositol polyphosphate phosphatase-like 1a.
     
 0.932
inpp5e
Inositol polyphosphate-5-phosphatase E.
     
 0.930
inpp5d
Inositol polyphosphate-5-phosphatase D.
     
 0.930
PTEN
Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family.
   
 0.924
pikfyve
Phosphoinositide kinase, FYVE finger containing.
   
 
 0.920
inpp4b
Inositol polyphosphate-4-phosphatase type II B.
     
 0.912
pi4k2a
Phosphatidylinositol 4-kinase type 2 alpha.
     
 0.908
pi4k2b
Phosphatidylinositol 4-kinase type 2 beta.
     
 0.908
Your Current Organism:
Poecilia reticulata
NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.