STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Kcnj1Potassium inwardly-rectifying channel, subfamily J, member 1a, tandem duplicate 6. (374 aa)    
Predicted Functional Partners:
cftr
Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer.
   
 0.610
ENSPREP00000004336
Uncharacterized protein.
  
 
 
0.504
LOC103481591
Potassium inwardly-rectifying channel, subfamily J, member 16.
  
 
 
0.499
LOC103460789
ATP-binding cassette, sub-family C (CFTR/MRP), member 9.
   
 0.450
abcc8
ATP-binding cassette, sub-family C (CFTR/MRP), member 8.
   
 0.450
KCNJ10
Potassium voltage-gated channel subfamily J member 10.
  
 
 
0.414
LOC103475914
Uncharacterized protein.
  
 
 
0.414
KCNJ15
Potassium voltage-gated channel subfamily J member 15.
  
 
 
0.413
Your Current Organism:
Poecilia reticulata
NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.