tdrd12 protein (Poecilia reticulata) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

tdrd12

Tudor domain containing 12. (1141 aa)

Predicted Functional Partners:

pes1

0.815

ebna1bp2

0.755

nop58

0.726

mtrex

0.718

gnl3

0.709

gnl3l

0.709

wdr12

0.705

sf3b1

0.700

piwil2

0.698

nop14

0.684

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ebna1bp2	gnl3	ENSPREP00000031115	ENSPREP00000004179	EBNA1 binding protein 2.	Guanine nucleotide binding protein-like 3 (nucleolar).	0.992
ebna1bp2	gnl3l	ENSPREP00000031115	ENSPREP00000032461	EBNA1 binding protein 2.	Guanine nucleotide binding protein-like 3 (nucleolar)-like.	0.991
ebna1bp2	mtrex	ENSPREP00000031115	ENSPREP00000004435	EBNA1 binding protein 2.	Mtr4 exosome RNA helicase.	0.715
ebna1bp2	nop14	ENSPREP00000031115	ENSPREP00000025074	EBNA1 binding protein 2.	NOP14 nucleolar protein homolog (yeast).	0.879
ebna1bp2	nop58	ENSPREP00000031115	ENSPREP00000020896	EBNA1 binding protein 2.	NOP58 ribonucleoprotein homolog (yeast).	0.985
ebna1bp2	pes1	ENSPREP00000031115	ENSPREP00000033339	EBNA1 binding protein 2.	Pescadillo homolog; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	0.999
ebna1bp2	tdrd12	ENSPREP00000031115	ENSPREP00000007148	EBNA1 binding protein 2.	Tudor domain containing 12.	0.755
ebna1bp2	wdr12	ENSPREP00000031115	ENSPREP00000020854	EBNA1 binding protein 2.	Ribosome biogenesis protein WDR12; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	0.995
gnl3	ebna1bp2	ENSPREP00000004179	ENSPREP00000031115	Guanine nucleotide binding protein-like 3 (nucleolar).	EBNA1 binding protein 2.	0.992
gnl3	mtrex	ENSPREP00000004179	ENSPREP00000004435	Guanine nucleotide binding protein-like 3 (nucleolar).	Mtr4 exosome RNA helicase.	0.792
gnl3	nop14	ENSPREP00000004179	ENSPREP00000025074	Guanine nucleotide binding protein-like 3 (nucleolar).	NOP14 nucleolar protein homolog (yeast).	0.769
gnl3	nop58	ENSPREP00000004179	ENSPREP00000020896	Guanine nucleotide binding protein-like 3 (nucleolar).	NOP58 ribonucleoprotein homolog (yeast).	0.912
gnl3	pes1	ENSPREP00000004179	ENSPREP00000033339	Guanine nucleotide binding protein-like 3 (nucleolar).	Pescadillo homolog; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	0.995
gnl3	tdrd12	ENSPREP00000004179	ENSPREP00000007148	Guanine nucleotide binding protein-like 3 (nucleolar).	Tudor domain containing 12.	0.709
gnl3	wdr12	ENSPREP00000004179	ENSPREP00000020854	Guanine nucleotide binding protein-like 3 (nucleolar).	Ribosome biogenesis protein WDR12; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	0.989
gnl3l	ebna1bp2	ENSPREP00000032461	ENSPREP00000031115	Guanine nucleotide binding protein-like 3 (nucleolar)-like.	EBNA1 binding protein 2.	0.991
gnl3l	mtrex	ENSPREP00000032461	ENSPREP00000004435	Guanine nucleotide binding protein-like 3 (nucleolar)-like.	Mtr4 exosome RNA helicase.	0.792
gnl3l	nop14	ENSPREP00000032461	ENSPREP00000025074	Guanine nucleotide binding protein-like 3 (nucleolar)-like.	NOP14 nucleolar protein homolog (yeast).	0.766
gnl3l	nop58	ENSPREP00000032461	ENSPREP00000020896	Guanine nucleotide binding protein-like 3 (nucleolar)-like.	NOP58 ribonucleoprotein homolog (yeast).	0.901
gnl3l	pes1	ENSPREP00000032461	ENSPREP00000033339	Guanine nucleotide binding protein-like 3 (nucleolar)-like.	Pescadillo homolog; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	0.995

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

29

average node degree:

5.27

avg. local clustering coefficient:

0.84

expected number of edges:

11

PPI enrichment p-value:

2.39e-06

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0044743

Protein transmembrane import into intracellular organelle

5 of 38

2.44

3.68

6.87e-08

GO:0065002

Intracellular protein transmembrane transport

5 of 53

2.29

3.4

1.63e-07

GO:0006626

Protein targeting to mitochondrion

4 of 46

2.26

2.5

1.34e-05

GO:0030150

Protein import into mitochondrial matrix

3 of 21

2.47

2.12

0.00011

GO:0006605

Protein targeting

5 of 172

1.78

2.1

1.90e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0051087

Chaperone binding

5 of 71

2.17

3.11

4.32e-07

GO:0004176

ATP-dependent peptidase activity

3 of 9

2.84

2.68

1.22e-05

GO:0140662

ATP-dependent protein folding chaperone

3 of 33

2.28

2.02

0.00014

GO:0140657

ATP-dependent activity

7 of 608

1.38

1.73

3.96e-06

GO:0051082

Unfolded protein binding

3 of 98

1.8

1.32

0.0020

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005759

Mitochondrial matrix

8 of 304

1.74

3.41

2.20e-10

GO:0005739

Mitochondrion

10 of 1452

1.16

1.59

7.23e-09

GO:0005743

Mitochondrial inner membrane

5 of 419

1.39

1.41

0.00016

GO:0005740

Mitochondrial envelope

6 of 673

1.27

1.35

5.72e-05

GO:0042645

Mitochondrial nucleoid

2 of 33

2.1

1.0

0.0130

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1894

Clp ATPase, C-terminal, and Endopeptidase Clp complex

4 of 5

3.22

4.26

1.82e-08

CL:6549

TIM23 mitochondrial import inner membrane translocase complex, and Tim44-like

4 of 10

2.92

3.98

4.62e-08

CL:1823

Mixed, incl. Chaperone cofactor-dependent protein refolding, and DnaJ domain, conserved site

5 of 43

2.38

3.76

3.76e-08

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-9609507

Protein localization

6 of 201

1.79

2.68

3.79e-07

MAP-1268020

Mitochondrial protein import

4 of 47

2.25

2.66

5.95e-06

Tissue Expression (TISSUES)

tissue

description

count in network

strength

signal

false discovery rate

BTO:0000862

Heart ventricle

2 of 192

1.34

0.67

0.0337

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005759

Mitochondrial matrix

7 of 205

1.85

3.43

2.61e-09

GOCC:0005739

Mitochondrion

8 of 936

1.25

1.63

4.35e-07

GOCC:0070013

Intracellular organelle lumen

9 of 1388

1.13

1.39

4.35e-07

GOCC:0005740

Mitochondrial envelope

4 of 383

1.34

0.92

0.0062

GOCC:0005743

Mitochondrial inner membrane

3 of 213

1.47

0.78

0.0221

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0496

Mitochondrion

4 of 160

1.72

1.63

0.00027

KW-0720

Serine protease

3 of 78

1.9

1.46

0.0012

KW-0811

Translocation

2 of 20

2.32

1.22

0.0054

KW-0143

Chaperone

2 of 22

2.28

1.22

0.0054

KW-0999

Mitochondrion inner membrane

2 of 56

1.87

0.89

0.0192

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR039544

Tim44-like

2 of 2

3.32

1.14

0.0090

IPR027065

Lon protease

2 of 2

3.32

1.14

0.0090

IPR017303

Mitochondrial import inner membrane translocase subunit Tim44

2 of 2

3.32

1.14

0.0090

IPR008269

Peptidase S16, Lon proteolytic domain

2 of 2

3.32

1.14

0.0090

IPR008268

Peptidase S16, active site

2 of 2

3.32

1.14

0.0090

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00978

Tim44 is an essential component of the machinery that mediates the translocation of nuclear-encoded proteins across the mitochondrial inner membrane PUBMED:10430866. Tim44 is thought to bind phospholipids of the mitochondrial inner membrane both by ...

2 of 3

3.14

1.55

0.0016

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