LOC103467654 protein (Poecilia reticulata) - STRING interaction network

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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[Homology]

Score

LOC103467654

Synaptotagmin IIa. (430 aa)

Predicted Functional Partners:

snap25

0.914

ENSPREP00000009573

0.826

ENSPREP00000004746

0.764

LOC103472839

0.695

ENSPREP00000002501

0.695

ENSPREP00000016345

0.695

syn1

0.685

LOC103472703

0.665

syt4

0.623

LOC103462615

0.623

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000002501	ENSPREP00000004746	ENSPREP00000002501	ENSPREP00000004746	Vesicle-associated membrane protein 2.	V-SNARE coiled-coil homology domain-containing protein.	0.765
ENSPREP00000002501	ENSPREP00000009573	ENSPREP00000002501	ENSPREP00000009573	Vesicle-associated membrane protein 2.	Synaptosomal-associated protein; Belongs to the SNAP-25 family.	0.875
ENSPREP00000002501	LOC103462615	ENSPREP00000002501	ENSPREP00000012268	Vesicle-associated membrane protein 2.	C2 domain-containing protein.	0.602
ENSPREP00000002501	LOC103467654	ENSPREP00000002501	ENSPREP00000007201	Vesicle-associated membrane protein 2.	Synaptotagmin IIa.	0.695
ENSPREP00000002501	snap25	ENSPREP00000002501	ENSPREP00000028419	Vesicle-associated membrane protein 2.	Synaptosomal-associated protein; Belongs to the SNAP-25 family.	0.951
ENSPREP00000002501	syn1	ENSPREP00000002501	ENSPREP00000016289	Vesicle-associated membrane protein 2.	Synapsin I.	0.522
ENSPREP00000002501	syt4	ENSPREP00000002501	ENSPREP00000001860	Vesicle-associated membrane protein 2.	Synaptotagmin IV.	0.602
ENSPREP00000004746	ENSPREP00000002501	ENSPREP00000004746	ENSPREP00000002501	V-SNARE coiled-coil homology domain-containing protein.	Vesicle-associated membrane protein 2.	0.765
ENSPREP00000004746	ENSPREP00000009573	ENSPREP00000004746	ENSPREP00000009573	V-SNARE coiled-coil homology domain-containing protein.	Synaptosomal-associated protein; Belongs to the SNAP-25 family.	0.964
ENSPREP00000004746	ENSPREP00000016345	ENSPREP00000004746	ENSPREP00000016345	V-SNARE coiled-coil homology domain-containing protein.	Zgc:92912.	0.765
ENSPREP00000004746	LOC103462615	ENSPREP00000004746	ENSPREP00000012268	V-SNARE coiled-coil homology domain-containing protein.	C2 domain-containing protein.	0.686
ENSPREP00000004746	LOC103467654	ENSPREP00000004746	ENSPREP00000007201	V-SNARE coiled-coil homology domain-containing protein.	Synaptotagmin IIa.	0.764
ENSPREP00000004746	LOC103472839	ENSPREP00000004746	ENSPREP00000001577	V-SNARE coiled-coil homology domain-containing protein.	Vesicle-associated membrane protein 1.	0.975
ENSPREP00000004746	snap25	ENSPREP00000004746	ENSPREP00000028419	V-SNARE coiled-coil homology domain-containing protein.	Synaptosomal-associated protein; Belongs to the SNAP-25 family.	0.989
ENSPREP00000004746	syn1	ENSPREP00000004746	ENSPREP00000016289	V-SNARE coiled-coil homology domain-containing protein.	Synapsin I.	0.446
ENSPREP00000004746	syt4	ENSPREP00000004746	ENSPREP00000001860	V-SNARE coiled-coil homology domain-containing protein.	Synaptotagmin IV.	0.686
ENSPREP00000009573	ENSPREP00000002501	ENSPREP00000009573	ENSPREP00000002501	Synaptosomal-associated protein; Belongs to the SNAP-25 family.	Vesicle-associated membrane protein 2.	0.875
ENSPREP00000009573	ENSPREP00000004746	ENSPREP00000009573	ENSPREP00000004746	Synaptosomal-associated protein; Belongs to the SNAP-25 family.	V-SNARE coiled-coil homology domain-containing protein.	0.964
ENSPREP00000009573	ENSPREP00000016345	ENSPREP00000009573	ENSPREP00000016345	Synaptosomal-associated protein; Belongs to the SNAP-25 family.	Zgc:92912.	0.875
ENSPREP00000009573	LOC103462615	ENSPREP00000009573	ENSPREP00000012268	Synaptosomal-associated protein; Belongs to the SNAP-25 family.	C2 domain-containing protein.	0.531

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Network Stats

number of nodes:

11

number of edges:

28

average node degree:

5.09

avg. local clustering coefficient:

0.894

expected number of edges:

14

PPI enrichment p-value:

0.000604

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006401

RNA catabolic process

4 of 12

2.05

2.0

0.00010

GO:0016070

RNA metabolic process

5 of 156

1.04

0.69

0.0104

GO:1901575

Organic substance catabolic process

5 of 225

0.88

0.49

0.0365

GO:0006139

Nucleobase-containing compound metabolic process

7 of 461

0.71

0.47

0.0168

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003724

RNA helicase activity

3 of 3

2.53

1.93

0.00027

GO:0004386

Helicase activity

4 of 21

1.81

1.69

0.00027

GO:0140657

ATP-dependent activity

5 of 135

1.1

0.81

0.0048

GO:0140098

Catalytic activity, acting on RNA

4 of 96

1.15

0.7

0.0166

GO:0140640

Catalytic activity, acting on a nucleic acid

5 of 174

0.99

0.65

0.0126

(more ...)

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:30678639

(2019) Transcriptome analysis of genes and metabolic pathways associated with nicotine degradation in Aspergillus oryzae 112822.

3 of 9

2.05

1.44

0.0016

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03018

RNA degradation

7 of 28

1.93

3.99

1.37e-10

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0347

Helicase

3 of 17

1.78

1.15

0.0047

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR014014

RNA helicase, DEAD-box type, Q motif

3 of 3

2.53

1.76

0.00055

IPR000629

ATP-dependent RNA helicase DEAD-box, conserved site

3 of 3

2.53

1.76

0.00055

IPR011545

DEAD/DEAH box helicase domain

3 of 8

2.11

1.47

0.0015

IPR014001

Helicase superfamily 1/2, ATP-binding domain

3 of 12

1.93

1.28

0.0031

IPR001650

Helicase, C-terminal

3 of 12

1.93

1.28

0.0031

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00487

DEAD-like helicases superfamily

4 of 13

2.02

2.41

1.01e-05

SM00490

Helicase superfamily c-terminal domain

4 of 15

1.96

2.36

1.01e-05

SM00316

Ribosomal protein S1-like RNA-binding domain

2 of 9

1.88

0.94

0.0153

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