STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
psen2Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (430 aa)    
Predicted Functional Partners:
NCSTN
Nicastrin.
   
 0.994
aph1a
APH1B gamma secretase subunit.
   
 0.993
psenen
Uncharacterized protein.
    
 0.975
LOC103473440
Notch receptor 1a.
    
 0.965
notch1
Notch receptor 1b.
    
 0.965
LOC103468742
Notch receptor 3.
    
 0.923
LOC103463625
Notch receptor 2.
    
 0.922
app
Amyloid beta (A4) precursor protein a.
    
 
 0.726
LOC103459816
Amyloid beta (A4) precursor protein b.
    
 
 0.726
ctnnb1
Catenin (cadherin-associated protein), beta 1.
    
 
 0.663
Your Current Organism:
Poecilia reticulata
NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.