LOC103462180 protein (Poecilia reticulata) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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Score

LOC103462180

Zinc finger protein 710b. (752 aa)

Predicted Functional Partners:

rps6kl1

0.476

LOC103473609

0.424

gtf3c3

0.421

gnrh2

0.408

pold1

0.401

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC103462180	LOC103473609	ENSPREP00000007307	ENSPREP00000011597	Zinc finger protein 710b.	POU domain protein.	0.424
LOC103462180	gnrh2	ENSPREP00000007307	ENSPREP00000030254	Zinc finger protein 710b.	Gonadoliberin; Stimulates the secretion of gonadotropins. Belongs to the GnRH family.	0.408
LOC103462180	gtf3c3	ENSPREP00000007307	ENSPREP00000027244	Zinc finger protein 710b.	General transcription factor IIIC, polypeptide 3.	0.421
LOC103462180	pold1	ENSPREP00000007307	ENSPREP00000020414	Zinc finger protein 710b.	DNA polymerase.	0.401
LOC103462180	rps6kl1	ENSPREP00000007307	ENSPREP00000013454	Zinc finger protein 710b.	Ribosomal protein S6 kinase-like 1.	0.476
LOC103473609	LOC103462180	ENSPREP00000011597	ENSPREP00000007307	POU domain protein.	Zinc finger protein 710b.	0.424
gnrh2	LOC103462180	ENSPREP00000030254	ENSPREP00000007307	Gonadoliberin; Stimulates the secretion of gonadotropins. Belongs to the GnRH family.	Zinc finger protein 710b.	0.408
gtf3c3	LOC103462180	ENSPREP00000027244	ENSPREP00000007307	General transcription factor IIIC, polypeptide 3.	Zinc finger protein 710b.	0.421
pold1	LOC103462180	ENSPREP00000020414	ENSPREP00000007307	DNA polymerase.	Zinc finger protein 710b.	0.401
pold1	rps6kl1	ENSPREP00000020414	ENSPREP00000013454	DNA polymerase.	Ribosomal protein S6 kinase-like 1.	0.469
rps6kl1	LOC103462180	ENSPREP00000013454	ENSPREP00000007307	Ribosomal protein S6 kinase-like 1.	Zinc finger protein 710b.	0.476
rps6kl1	pold1	ENSPREP00000013454	ENSPREP00000020414	Ribosomal protein S6 kinase-like 1.	DNA polymerase.	0.469

Network Stats

number of nodes:

4

number of edges:

3

average node degree:

1.5

avg. local clustering coefficient:

0.75

expected number of edges:

3

PPI enrichment p-value:

0.564

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006084

acetyl-CoA metabolic process

5 of 13

2.93

5.3

1.41e-10

GO:0006086

acetyl-CoA biosynthetic process from pyruvate

4 of 7

3.11

4.74

2.06e-09

GO:0019752

Carboxylic acid metabolic process

8 of 477

1.57

2.75

2.06e-09

GO:0045454

Cell redox homeostasis

3 of 20

2.53

2.65

1.03e-05

GO:0009063

Cellular amino acid catabolic process

3 of 42

2.2

2.15

6.41e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004148

Dihydrolipoyl dehydrogenase activity

3 of 6

3.05

2.81

7.67e-06

GO:0016624

Oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor

3 of 8

2.92

2.8

7.67e-06

GO:0016746

Acyltransferase activity

5 of 166

1.83

2.29

7.67e-06

GO:0003863

3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity

2 of 2

3.35

2.04

0.00021

GO:0016491

Oxidoreductase activity

6 of 680

1.29

1.4

5.20e-05

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:1990204

Oxidoreductase complex

10 of 45

2.7

11.15

9.60e-24

GO:0045240

Dihydrolipoyl dehydrogenase complex

6 of 12

3.05

7.52

9.24e-15

GO:0045254

Pyruvate dehydrogenase complex

4 of 5

3.25

5.34

1.81e-10

GO:0005759

Mitochondrial matrix

6 of 76

2.25

4.87

3.83e-11

GO:0045252

Oxoglutarate dehydrogenase complex

4 of 10

2.95

4.8

1.30e-09

(more ...)

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:23006831

(2012) Transcriptomic analysis of the oleaginous microalga Neochloris oleoabundans reveals metabolic insights into triacylglyceride accumulation.

3 of 3

3.35

2.98

4.18e-06

PMID:34702846

(2021) MinION sequencing from sea ice cryoconites leads to de novo genome reconstruction from metagenomes.

3 of 4

3.22

2.97

4.18e-06

PMID:30619403

(2018) Knock-Down of the Phosphoserine Phosphatase Gene Effects Rather N- Than S-Metabolism in Arabidopsis thaliana.

3 of 5

3.13

2.96

4.18e-06

PMID:31266864

(2019) DayNight Separation of Oxygenic Energy Metabolism and Nuclear DNA Replication in the Unicellular Red Alga Cyanidioschyzon merolae.

3 of 8

2.92

2.77

8.61e-06

PMID:33413098

(2021) Nutrient-imbalanced conditions shift the interplay between zooplankton and gut microbiota.

3 of 9

2.87

2.75

9.18e-06

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:14150

Dihydrolipoyl dehydrogenase complex, and acetyl-CoA biosynthetic process from pyruvate

11 of 19

3.11

15.36

2.61e-30

CL:14153

Citrate cycle (TCA cycle)

8 of 12

3.17

11.04

2.13e-21

CL:14155

acetyl-CoA biosynthetic process from pyruvate, and Dihydrolipoyl dehydrogenase activity

5 of 6

3.27

6.6

8.43e-13

CL:14167

Thiamine pyrophosphate binding, and Succinyltransferase activity

2 of 5

2.95

1.66

0.0010

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

gtt00020

Citrate cycle (TCA cycle)

8 of 22

2.91

10.09

3.15e-20

gtt00620

Pyruvate metabolism

7 of 42

2.57

7.41

9.44e-16

gtt00640

Propanoate metabolism

6 of 21

2.8

7.37

6.87e-15

gtt00280

Valine, leucine and isoleucine degradation

6 of 26

2.71

7.05

1.84e-14

gtt00010

Glycolysis / Gluconeogenesis

7 of 55

2.45

6.94

3.00e-15

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-389661

Glyoxylate metabolism and glycine degradation

11 of 42

2.77

13.04

1.33e-27

MAP-70268

Pyruvate metabolism

7 of 26

2.78

8.0

2.81e-16

MAP-71406

Pyruvate metabolism and Citric Acid (TCA) cycle

8 of 53

2.53

7.88

4.20e-17

MAP-71291

Metabolism of amino acids and derivatives

11 of 248

2.0

6.55

6.19e-20

MAP-70895

Branched-chain amino acid catabolism

6 of 28

2.68

6.44

2.90e-13

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:1990204

Oxidoreductase complex

7 of 37

2.63

7.06

9.50e-15

GOCC:0045254

Pyruvate dehydrogenase complex

4 of 7

3.11

4.66

2.90e-09

GOCC:0045240

Dihydrolipoyl dehydrogenase complex

3 of 6

3.05

3.26

1.13e-06

GOCC:0005947

Mitochondrial alpha-ketoglutarate dehydrogenase complex

2 of 2

3.35

2.2

0.00011

GOCC:0005759

Mitochondrial matrix

3 of 56

2.08

1.91

0.00017

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0450

Lipoyl

3 of 4

3.22

3.46

5.20e-07

KW-0012

Acyltransferase

3 of 35

2.28

2.27

4.15e-05

KW-0560

Oxidoreductase

4 of 136

1.82

2.03

3.60e-05

KW-0786

Thiamine pyrophosphate

2 of 5

2.95

2.03

0.00021

KW-0676

Redox-active center

2 of 20

2.35

1.46

0.0019

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00198

2-oxoacid dehydrogenases acyltransferase (catalytic domain)

5 of 5

3.35

6.4

2.19e-12

PF02817

e3 binding domain

3 of 3

3.35

3.34

9.36e-07

PF00364

Biotin-requiring enzyme

3 of 9

2.87

2.82

6.86e-06

PF02852

Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain

3 of 14

2.68

2.59

1.59e-05

PF02780

Transketolase, C-terminal domain

2 of 7

2.8

1.51

0.0018

(more ...)

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR001078

2-oxoacid dehydrogenase acyltransferase, catalytic domain

5 of 5

3.35

6.17

5.90e-12

IPR023213

Chloramphenicol acetyltransferase-like domain superfamily

5 of 15

2.87

5.21

1.81e-10

IPR036625

E3-binding domain superfamily

3 of 3

3.35

3.19

1.69e-06

IPR004167

Peripheral subunit-binding domain

3 of 3

3.35

3.19

1.69e-06

IPR045257

Dihydrolipoamide acetyltransferase/Pyruvate dehydrogenase protein X component

3 of 4

3.22

3.17

1.77e-06

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00861

Transketolase, pyrimidine binding domain

2 of 8

2.75

1.39

0.0030

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