LOC103471207 protein (Poecilia reticulata) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Cooccurrence

Coexpression

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[Homology]

Score

LOC103471207

Glucosamine-6-phosphate isomerase. (283 aa)

Predicted Functional Partners:

amdhd2

0.998

gnpnat1

0.959

gpi

0.953

LOC103466381

0.953

LOC103471255

0.952

LOC103470517

0.952

mpi

0.944

ENSPREP00000013735

0.918

LOC103462844

0.918

LOC103462845

0.918

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000013735	LOC103462844	ENSPREP00000013735	ENSPREP00000023097	Phosphotransferase.	Hexokinase domain containing 1.	0.901
ENSPREP00000013735	LOC103462845	ENSPREP00000013735	ENSPREP00000023282	Phosphotransferase.	Phosphotransferase.	0.991
ENSPREP00000013735	LOC103466381	ENSPREP00000013735	ENSPREP00000024990	Phosphotransferase.	Glucose-6-phosphate isomerase; Belongs to the GPI family.	0.952
ENSPREP00000013735	LOC103470517	ENSPREP00000013735	ENSPREP00000010325	Phosphotransferase.	Glutamine--fructose-6-phosphate transaminase 1.	0.918
ENSPREP00000013735	LOC103471207	ENSPREP00000013735	ENSPREP00000007318	Phosphotransferase.	Glucosamine-6-phosphate isomerase.	0.918
ENSPREP00000013735	LOC103471255	ENSPREP00000013735	ENSPREP00000005591	Phosphotransferase.	Glutamine-fructose-6-phosphate transaminase 2.	0.918
ENSPREP00000013735	amdhd2	ENSPREP00000013735	ENSPREP00000016567	Phosphotransferase.	N-acetylglucosamine-6-phosphate deacetylase; Belongs to the metallo-dependent hydrolases superfamily. NagA family.	0.926
ENSPREP00000013735	gnpnat1	ENSPREP00000013735	ENSPREP00000004623	Phosphotransferase.	Glucosamine 6-phosphate N-acetyltransferase.	0.926
ENSPREP00000013735	gpi	ENSPREP00000013735	ENSPREP00000010994	Phosphotransferase.	Glucose-6-phosphate isomerase; Belongs to the GPI family.	0.952
ENSPREP00000013735	mpi	ENSPREP00000013735	ENSPREP00000020043	Phosphotransferase.	Mannose phosphate isomerase.	0.934
LOC103462844	ENSPREP00000013735	ENSPREP00000023097	ENSPREP00000013735	Hexokinase domain containing 1.	Phosphotransferase.	0.901
LOC103462844	LOC103462845	ENSPREP00000023097	ENSPREP00000023282	Hexokinase domain containing 1.	Phosphotransferase.	0.901
LOC103462844	LOC103466381	ENSPREP00000023097	ENSPREP00000024990	Hexokinase domain containing 1.	Glucose-6-phosphate isomerase; Belongs to the GPI family.	0.952
LOC103462844	LOC103470517	ENSPREP00000023097	ENSPREP00000010325	Hexokinase domain containing 1.	Glutamine--fructose-6-phosphate transaminase 1.	0.918
LOC103462844	LOC103471207	ENSPREP00000023097	ENSPREP00000007318	Hexokinase domain containing 1.	Glucosamine-6-phosphate isomerase.	0.918
LOC103462844	LOC103471255	ENSPREP00000023097	ENSPREP00000005591	Hexokinase domain containing 1.	Glutamine-fructose-6-phosphate transaminase 2.	0.918
LOC103462844	amdhd2	ENSPREP00000023097	ENSPREP00000016567	Hexokinase domain containing 1.	N-acetylglucosamine-6-phosphate deacetylase; Belongs to the metallo-dependent hydrolases superfamily. NagA family.	0.926
LOC103462844	gnpnat1	ENSPREP00000023097	ENSPREP00000004623	Hexokinase domain containing 1.	Glucosamine 6-phosphate N-acetyltransferase.	0.926
LOC103462844	gpi	ENSPREP00000023097	ENSPREP00000010994	Hexokinase domain containing 1.	Glucose-6-phosphate isomerase; Belongs to the GPI family.	0.952
LOC103462844	mpi	ENSPREP00000023097	ENSPREP00000020043	Hexokinase domain containing 1.	Mannose phosphate isomerase.	0.934

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

10

average node degree:

1.82

avg. local clustering coefficient:

0.909

expected number of edges:

11

PPI enrichment p-value:

0.62

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030177

Positive regulation of Wnt signaling pathway

6 of 96

2.06

3.43

3.52e-08

GO:0030111

Regulation of Wnt signaling pathway

8 of 248

1.77

3.35

1.03e-09

GO:0016055

Wnt signaling pathway

5 of 182

1.7

1.77

0.00010

GO:2001013

Epithelial cell proliferation involved in renal tubule morphogenesis

2 of 4

2.96

1.33

0.0040

GO:0060828

Regulation of canonical Wnt signaling pathway

4 of 190

1.59

1.15

0.0031

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016500

Protein-hormone receptor activity

3 of 19

2.46

1.75

0.00055

GO:0008201

Heparin binding

4 of 129

1.76

1.45

0.00086

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005576

Extracellular region

7 of 1991

0.81

0.47

0.0325

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:27104524

(2016) Exogenous R-Spondin1 Induces Precocious Telogen-to-Anagen Transition in Mouse Hair Follicles.

9 of 37

2.65

8.72

2.25e-18

PMID:29416699

(2018) LGR5 and LGR6 in stem cell biology and ovarian cancer.

7 of 16

2.9

7.43

8.53e-15

PMID:22982762

(2012) The R-spondin family of proteins: emerging regulators of WNT signaling.

7 of 53

2.38

5.37

8.90e-12

PMID:25276837

(2014) Computational biophysical, biochemical, and evolutionary signature of human R-spondin family proteins, the member of canonical Wntbeta-catenin signaling pathway.

5 of 25

2.56

3.91

3.36e-08

PMID:38255775

(2024) Adult Animal Stem Cell-Derived Organoids in Biomedical Research and the One Health Paradigm.

5 of 45

2.31

3.24

3.98e-07

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:15139

Mixed, incl. Regulation of FZD by ubiquitination, and WSC domain

9 of 14

3.07

11.51

1.31e-22

CL:15143

Epithelial cell proliferation involved in renal tubule morphogenesis, and Furin-like repeat

5 of 5

3.26

6.25

3.73e-12

CL:20511

Teneurin Intracellular Region, and Latrophilin Cytoplasmic C-terminal region

2 of 6

2.79

1.24

0.0057

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

cfa04310

Wnt signaling pathway

8 of 135

2.04

5.08

2.77e-13

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

CFA-4641263

Regulation of FZD by ubiquitination

7 of 15

2.93

8.16

3.29e-16

Tissue Expression (TISSUES)

tissue

description

count in network

strength

signal

false discovery rate

BTO:0000305

Crypt

2 of 9

2.61

0.84

0.0302

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0732

Signal

7 of 2280

0.75

0.47

0.0212

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02354

Latrophilin Cytoplasmic C-terminal region

2 of 3

3.09

1.22

0.0062

PF02140

Galactose binding lectin domain

2 of 5

2.87

1.21

0.0065

PF16489

GPCR-Autoproteolysis INducing (GAIN) domain

2 of 10

2.56

1.02

0.0136

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00261

Furin-like repeats

4 of 16

2.66

3.59

1.85e-07

SM00209

Thrombospondin type 1 repeats

4 of 61

2.08

2.41

1.28e-05

SM00284

Olfactomedin-like domains

2 of 14

2.42

1.12

0.0087

SM00008

Domain present in hormone receptors

2 of 23

2.2

1.01

0.0130

SM00369

Leucine-rich repeats, typical (most populated) subfamily

3 of 122

1.65

1.0

0.0087

(more ...)

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