ufsp2 protein (Poecilia reticulata) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

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Textmining

[Homology]

Score

ufsp2

Ufm1-specific peptidase 2. (497 aa)

Predicted Functional Partners:

ufm1

0.956

uba5

0.712

ufl1

0.668

UFC1

0.661

odr4

0.650

ddrgk1

0.638

cdk5rap3

0.570

trip4

0.549

sgsm3

0.542

ccdc86

0.477

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
UFC1	cdk5rap3	ENSPREP00000025245	ENSPREP00000019140	Ubiquitin-fold modifier conjugating enzyme 1.	CDK5 regulatory subunit associated protein 3.	0.591
UFC1	ddrgk1	ENSPREP00000025245	ENSPREP00000026059	Ubiquitin-fold modifier conjugating enzyme 1.	Uncharacterized protein.	0.788
UFC1	trip4	ENSPREP00000025245	ENSPREP00000009660	Ubiquitin-fold modifier conjugating enzyme 1.	Thyroid hormone receptor interactor 4.	0.440
UFC1	uba5	ENSPREP00000025245	ENSPREP00000013586	Ubiquitin-fold modifier conjugating enzyme 1.	Ubiquitin-like modifier activating enzyme 5.	0.968
UFC1	ufl1	ENSPREP00000025245	ENSPREP00000002935	Ubiquitin-fold modifier conjugating enzyme 1.	UFM1-specific ligase 1.	0.792
UFC1	ufm1	ENSPREP00000025245	ENSPREP00000017768	Ubiquitin-fold modifier conjugating enzyme 1.	Ubiquitin-fold modifier 1.	0.927
UFC1	ufsp2	ENSPREP00000025245	ENSPREP00000007391	Ubiquitin-fold modifier conjugating enzyme 1.	Ufm1-specific peptidase 2.	0.661
ccdc86	ufsp2	ENSPREP00000007998	ENSPREP00000007391	Si:ch211-217k17.7.	Ufm1-specific peptidase 2.	0.477
cdk5rap3	UFC1	ENSPREP00000019140	ENSPREP00000025245	CDK5 regulatory subunit associated protein 3.	Ubiquitin-fold modifier conjugating enzyme 1.	0.591
cdk5rap3	ddrgk1	ENSPREP00000019140	ENSPREP00000026059	CDK5 regulatory subunit associated protein 3.	Uncharacterized protein.	0.953
cdk5rap3	uba5	ENSPREP00000019140	ENSPREP00000013586	CDK5 regulatory subunit associated protein 3.	Ubiquitin-like modifier activating enzyme 5.	0.549
cdk5rap3	ufl1	ENSPREP00000019140	ENSPREP00000002935	CDK5 regulatory subunit associated protein 3.	UFM1-specific ligase 1.	0.954
cdk5rap3	ufm1	ENSPREP00000019140	ENSPREP00000017768	CDK5 regulatory subunit associated protein 3.	Ubiquitin-fold modifier 1.	0.491
cdk5rap3	ufsp2	ENSPREP00000019140	ENSPREP00000007391	CDK5 regulatory subunit associated protein 3.	Ufm1-specific peptidase 2.	0.570
ddrgk1	UFC1	ENSPREP00000026059	ENSPREP00000025245	Uncharacterized protein.	Ubiquitin-fold modifier conjugating enzyme 1.	0.788
ddrgk1	cdk5rap3	ENSPREP00000026059	ENSPREP00000019140	Uncharacterized protein.	CDK5 regulatory subunit associated protein 3.	0.953
ddrgk1	uba5	ENSPREP00000026059	ENSPREP00000013586	Uncharacterized protein.	Ubiquitin-like modifier activating enzyme 5.	0.550
ddrgk1	ufl1	ENSPREP00000026059	ENSPREP00000002935	Uncharacterized protein.	UFM1-specific ligase 1.	0.953
ddrgk1	ufm1	ENSPREP00000026059	ENSPREP00000017768	Uncharacterized protein.	Ubiquitin-fold modifier 1.	0.728
ddrgk1	ufsp2	ENSPREP00000026059	ENSPREP00000007391	Uncharacterized protein.	Ufm1-specific peptidase 2.	0.638

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

33

average node degree:

6

avg. local clustering coefficient:

0.785

expected number of edges:

10

PPI enrichment p-value:

1.14e-08

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:1902766

Skeletal muscle satellite cell migration

5 of 8

3.11

5.46

9.25e-11

GO:0044319

Wound healing, spreading of cells

5 of 22

2.67

4.5

2.89e-09

GO:0030865

Cortical cytoskeleton organization

5 of 70

2.17

3.28

1.75e-07

GO:0007163

Establishment or maintenance of cell polarity

6 of 180

1.84

2.87

1.61e-07

GO:0008360

Regulation of cell shape

5 of 123

1.93

2.58

2.32e-06

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003924

GTPase activity

5 of 388

1.43

1.15

0.0017

GO:0019901

Protein kinase binding

5 of 438

1.38

1.12

0.0017

GO:0005525

GTP binding

5 of 547

1.28

1.02

0.0022

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005938

Cell cortex

5 of 275

1.58

1.6

0.00015

GO:0005856

Cytoskeleton

8 of 2042

0.91

0.81

0.00033

GO:0043005

Neuron projection

5 of 1119

0.97

0.56

0.0286

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:41527

ARHGEF1-like, PH domain, and TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)

5 of 5

3.32

6.01

1.12e-11

CL:12995

Mixed, incl. Formin, FH2 domain, and Sema4D in semaphorin signaling

5 of 41

2.4

4.01

1.20e-08

CL:13053

Mixed, incl. Rho GTPase-activating protein, FF domain, and HR1 repeat superfamily

3 of 12

2.72

2.56

1.88e-05

CL:13027

Diaphanous FH3 Domain, and Skeletal muscle satellite cell migration

2 of 7

2.77

1.36

0.0034

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

pret04530

Tight junction

11 of 194

2.07

7.27

3.81e-21

pret04150

mTOR signaling pathway

6 of 167

1.87

3.36

6.39e-09

pret04520

Adherens junction

5 of 99

2.02

3.34

4.42e-08

pret04625

C-type lectin receptor signaling pathway

5 of 101

2.01

3.33

4.42e-08

pret04350

TGF-beta signaling pathway

5 of 105

2.0

3.3

4.42e-08

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-5627117

RHO GTPases Activate ROCKs

5 of 12

2.94

5.4

9.10e-11

MAP-5625900

RHO GTPases activate CIT

5 of 17

2.79

5.15

1.94e-10

MAP-416572

Sema4D induced cell migration and growth-cone collapse

5 of 21

2.69

4.98

3.22e-10

MAP-400685

Sema4D in semaphorin signaling

5 of 25

2.62

4.83

5.23e-10

MAP-416482

G alpha (12/13) signalling events

6 of 115

2.04

3.79

2.91e-09

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0032154

Cleavage furrow

5 of 52

2.3

3.62

5.62e-08

GOCC:0005903

Brush border

2 of 28

2.17

0.79

0.0348

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0342

GTP-binding

5 of 242

1.63

1.93

2.07e-05

KW-0547

Nucleotide-binding

6 of 1223

1.01

0.83

0.0015

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR003578

Small GTPase Rho

5 of 40

2.41

3.65

7.62e-08

IPR001806

Small GTPase

5 of 189

1.74

1.87

6.56e-05

IPR005225

Small GTP-binding protein domain

5 of 217

1.68

1.78

8.59e-05

IPR041020

ARHGEF1-like, PH domain

2 of 7

2.77

1.03

0.0134

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00174

Rho (Ras homology) subfamily of Ras-like small GTPases

5 of 35

2.47

4.27

4.50e-09

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