Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
trhdeThyrotropin releasing hormone degrading enzyme, tandem duplicate 2. (1013 aa)    
Predicted Functional Partners:
agt
Angiotensinogen; Belongs to the serpin family.
   
 0.636
hspa5
Heat shock protein 5; Belongs to the heat shock protein 70 family.
    
 0.444
cln5
CLN5 intracellular trafficking protein.
      
 0.443
dld
Dihydrolipoyl dehydrogenase.
   
 0.423
gsr
Glutathione reductase; Maintains high levels of reduced glutathione in the cytosol. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
   
 0.421
agtr2
Angiotensin II receptor, type 2; Belongs to the G-protein coupled receptor 1 family.
   
 
 0.415
Your Current Organism:
Poecilia reticulata
NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy
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