Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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Co-expression
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[Homology]
Score
ENSPREP00000007581SH3 domain-containing protein. (95 aa)    
Predicted Functional Partners:
ppp1r1b
Protein phosphatase 1, regulatory (inhibitor) subunit 1B.
      
 0.573
fpgt
Fucose-1-phosphate guanylyltransferase.
      
 0.537
dock5
Dedicator of cytokinesis 5; Belongs to the DOCK family.
      
 0.537
rrm2b
Ribonucleotide reductase M2 b.
      
 0.503
rrm2
Ribonucleotide reductase M2 polypeptide.
      
 0.503
LOC103467989
Elastase 2; Belongs to the peptidase S1 family.
      
 0.462
ENSPREP00000004733
Uncharacterized protein.
    
 
 0.461
rasa1
RAS p21 protein activator (GTPase activating protein) 1a.
      
 0.461
zyx
Zyxin.
    
 
 0.461
LOC103481623
Zgc:112285; Belongs to the peptidase S1 family.
      
 0.458
Your Current Organism:
Poecilia reticulata
NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy
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