STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
fbxo42F-box protein 42. (701 aa)    
Predicted Functional Partners:
cul1
Cullin 1b; Belongs to the cullin family.
    
 
 0.980
skp1
S-phase kinase-associated protein 1; Belongs to the SKP1 family.
    
 
 0.941
rbx1
Ring-box 1, E3 ubiquitin protein ligase.
    
 0.933
tp53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
    
 
 0.896
ccdc6
Coiled-coil domain containing 6a.
    
 
 0.889
fbxo41
F-box protein 41.
      
 0.809
LOC103469257
Recombination signal binding protein for immunoglobulin kappa J region a.
   
   0.796
rbpj
Recombination signal binding protein for immunoglobulin kappa J region.
   
   0.796
chek2
Checkpoint kinase 2.
   
  
 0.761
LOC103479391
CULLIN_2 domain-containing protein; Belongs to the cullin family.
    
 
 0.721
Your Current Organism:
Poecilia reticulata
NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.