ENSPREP00000007769 protein (Poecilia reticulata)

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second shell of interactors

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a 3D structure is known or predicted

Edges:

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

ENSPREP00000007769

Filamin binding LIM protein 1. (273 aa)

Predicted Functional Partners:

fermt2

0.787

fermt1

0.787

ENSPREP00000005335

0.750

ENSPREP00000006034

0.750

ENSPREP00000006052

0.750

LOC103466954

0.750

flnc

0.750

flnb

0.750

Haus1

0.725

haus3

0.723

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000005335	ENSPREP00000006034	ENSPREP00000005335	ENSPREP00000006034	Calponin-homology (CH) domain-containing protein.	Uncharacterized protein.	0.899
ENSPREP00000005335	ENSPREP00000007769	ENSPREP00000005335	ENSPREP00000007769	Calponin-homology (CH) domain-containing protein.	Filamin binding LIM protein 1.	0.750
ENSPREP00000005335	flnb	ENSPREP00000005335	ENSPREP00000033899	Calponin-homology (CH) domain-containing protein.	Filamin B.	0.899
ENSPREP00000006034	ENSPREP00000005335	ENSPREP00000006034	ENSPREP00000005335	Uncharacterized protein.	Calponin-homology (CH) domain-containing protein.	0.899
ENSPREP00000006034	ENSPREP00000006052	ENSPREP00000006034	ENSPREP00000006052	Uncharacterized protein.	Calponin-homology (CH) domain-containing protein.	0.900
ENSPREP00000006034	ENSPREP00000007769	ENSPREP00000006034	ENSPREP00000007769	Uncharacterized protein.	Filamin binding LIM protein 1.	0.750
ENSPREP00000006052	ENSPREP00000006034	ENSPREP00000006052	ENSPREP00000006034	Calponin-homology (CH) domain-containing protein.	Uncharacterized protein.	0.900
ENSPREP00000006052	ENSPREP00000007769	ENSPREP00000006052	ENSPREP00000007769	Calponin-homology (CH) domain-containing protein.	Filamin binding LIM protein 1.	0.750
ENSPREP00000006052	LOC103466954	ENSPREP00000006052	ENSPREP00000008589	Calponin-homology (CH) domain-containing protein.	Uncharacterized protein.	0.900
ENSPREP00000006052	flnb	ENSPREP00000006052	ENSPREP00000033899	Calponin-homology (CH) domain-containing protein.	Filamin B.	0.989
ENSPREP00000007769	ENSPREP00000005335	ENSPREP00000007769	ENSPREP00000005335	Filamin binding LIM protein 1.	Calponin-homology (CH) domain-containing protein.	0.750
ENSPREP00000007769	ENSPREP00000006034	ENSPREP00000007769	ENSPREP00000006034	Filamin binding LIM protein 1.	Uncharacterized protein.	0.750
ENSPREP00000007769	ENSPREP00000006052	ENSPREP00000007769	ENSPREP00000006052	Filamin binding LIM protein 1.	Calponin-homology (CH) domain-containing protein.	0.750
ENSPREP00000007769	Haus1	ENSPREP00000007769	ENSPREP00000018642	Filamin binding LIM protein 1.	HAUS augmin-like complex, subunit 1.	0.725
ENSPREP00000007769	LOC103466954	ENSPREP00000007769	ENSPREP00000008589	Filamin binding LIM protein 1.	Uncharacterized protein.	0.750
ENSPREP00000007769	fermt1	ENSPREP00000007769	ENSPREP00000024000	Filamin binding LIM protein 1.	Fermitin family member 1.	0.787
ENSPREP00000007769	fermt2	ENSPREP00000007769	ENSPREP00000010340	Filamin binding LIM protein 1.	Fermitin family member 2.	0.787
ENSPREP00000007769	flnb	ENSPREP00000007769	ENSPREP00000033899	Filamin binding LIM protein 1.	Filamin B.	0.750
ENSPREP00000007769	flnc	ENSPREP00000007769	ENSPREP00000028401	Filamin binding LIM protein 1.	Filamin C, gamma b (actin binding protein 280).	0.750
ENSPREP00000007769	haus3	ENSPREP00000007769	ENSPREP00000005944	Filamin binding LIM protein 1.	HAUS augmin-like complex, subunit 3.	0.723

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

13

average node degree:

2.36

avg. local clustering coefficient:

0.915

expected number of edges:

10

PPI enrichment p-value:

0.232

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0046488

Phosphatidylinositol metabolic process

9 of 175

2.03

5.27

5.11e-14

GO:0046486

Glycerolipid metabolic process

10 of 342

1.78

4.32

5.11e-14

GO:0006629

Lipid metabolic process

11 of 1175

1.29

2.15

1.13e-11

GO:0045017

Glycerolipid biosynthetic process

5 of 205

1.7

2.0

2.23e-05

GO:0043647

Inositol phosphate metabolic process

3 of 34

2.26

1.8

0.00037

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004435

Phosphatidylinositol phospholipase C activity

4 of 24

2.54

3.22

7.90e-07

GO:0042578

Phosphoric ester hydrolase activity

8 of 473

1.55

2.52

1.51e-08

GO:0046030

Inositol trisphosphate phosphatase activity

2 of 17

2.39

1.12

0.0087

GO:0016791

Phosphatase activity

4 of 351

1.37

0.99

0.0046

GO:0052866

Phosphatidylinositol phosphate phosphatase activity

2 of 45

1.97

0.71

0.0463

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:27029

Inositol phosphate metabolism, and Inositol hexakisphosphate 5-kinase activity

9 of 84

2.35

7.32

5.58e-17

CL:27030

Inositol phosphate metabolism

8 of 67

2.39

6.88

1.86e-15

CL:27032

Inositol phosphate metabolism

7 of 45

2.51

6.48

6.76e-14

CL:27033

Inositol phosphate metabolism

6 of 39

2.5

5.46

1.34e-11

CL:27060

Mixed, incl. 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1, catalytic domain, and 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3, EF hand domain

4 of 10

2.92

4.19

1.81e-08

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

pret00562

Inositol phosphate metabolism

11 of 82

2.45

10.56

4.53e-25

pret04070

Phosphatidylinositol signaling system

11 of 88

2.41

10.39

4.68e-25

pret01100

Metabolic pathways

11 of 1488

1.19

1.85

5.14e-12

pret04020

Calcium signaling pathway

4 of 250

1.52

0.00019

pret04370

VEGF signaling pathway

2 of 64

1.81

0.94

0.0147

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1483249

Inositol phosphate metabolism

8 of 73

2.36

6.63

4.73e-15

MAP-1855204

Synthesis of IP3 and IP4 in the cytosol

5 of 45

2.36

3.92

1.55e-08

MAP-1660517

Synthesis of PIPs at the late endosome membrane

2 of 7

2.77

1.38

0.0031

MAP-202403

TCR signaling

3 of 80

1.89

1.27

0.0031

MAP-1660516

Synthesis of PIPs at the early endosome membrane

2 of 15

2.44

1.18

0.0068

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0443

Lipid metabolism

5 of 102

2.01

3.0

3.08e-07

KW-0442

Lipid degradation

3 of 45

2.14

1.86

0.00024

KW-0378

Hydrolase

5 of 768

1.13

0.92

0.0019

KW-0807

Transducer

4 of 562

1.17

0.79

0.0089

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR001711

Phospholipase C, phosphatidylinositol-specific, Y domain

4 of 23

2.56

2.9

3.59e-06

IPR001192

Phosphoinositide phospholipase C family

4 of 23

2.56

2.9

3.59e-06

IPR000909

Phosphatidylinositol-specific phospholipase C, X domain

4 of 29

2.46

2.86

3.59e-06

IPR017946

PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily

4 of 40

2.32

2.66

6.91e-06

IPR035892

C2 domain superfamily

5 of 228

1.66

1.79

6.56e-05

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00149

Phospholipase C, catalytic domain (part)

4 of 23

2.56

3.38

3.93e-07

SM00148

Phospholipase C, catalytic domain (part)

4 of 23

2.56

3.38

3.93e-07

SM00239

Protein kinase C conserved region 2 (CalB)

4 of 185

1.65

1.53

0.00037

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