Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
LOC103475404Heat shock protein 4a. (799 aa)    
Predicted Functional Partners:
stip1
Stress-induced phosphoprotein 1.
   
 0.984
hspa5
Heat shock protein 5; Belongs to the heat shock protein 70 family.
  
0.977
bag3
BCL2 associated athanogene 3.
   
 0.975
hspa4l
Heat shock protein 4 like.
   
  0.962
stub1
STIP1 homology and U-Box containing protein 1.
    
 
 0.958
LOC103473856
Uncharacterized protein; Belongs to the synuclein family.
    
 
 0.946
tp53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
   
 
 0.939
ENSPREP00000020277
RBR-type E3 ubiquitin transferase.
    
 
 0.933
bag2
BCL2 associated athanogene 2.
   
 0.928
bag5
BCL2 associated athanogene 5.
   
 0.921
Your Current Organism:
Poecilia reticulata
NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy
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