ndfip1 protein (Poecilia reticulata) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

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Databases

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[Homology]

Score

ndfip1

Nedd4 family interacting protein 1, like. (230 aa)

Predicted Functional Partners:

trip12

0.563

nedd4

0.502

nedd4l

0.502

SLC11A2

0.491

LOC103467973

0.491

wwp2

0.478

wwp1

0.478

ndufa6

0.468

itch

0.420

LOC103464828

0.420

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC103464828	itch	ENSPREP00000023584	ENSPREP00000001984	E3 ubiquitin-protein ligase.	E3 ubiquitin-protein ligase.	0.901
LOC103464828	ndfip1	ENSPREP00000023584	ENSPREP00000007942	E3 ubiquitin-protein ligase.	Nedd4 family interacting protein 1, like.	0.420
LOC103464828	wwp1	ENSPREP00000023584	ENSPREP00000010715	E3 ubiquitin-protein ligase.	WW domain containing E3 ubiquitin protein ligase 1.	0.629
LOC103464828	wwp2	ENSPREP00000023584	ENSPREP00000004465	E3 ubiquitin-protein ligase.	E3 ubiquitin-protein ligase.	0.631
LOC103467973	SLC11A2	ENSPREP00000029748	ENSPREP00000020123	Solute carrier family 11 member 2.	Solute carrier family 11 member 2.	0.901
LOC103467973	ndfip1	ENSPREP00000029748	ENSPREP00000007942	Solute carrier family 11 member 2.	Nedd4 family interacting protein 1, like.	0.491
SLC11A2	LOC103467973	ENSPREP00000020123	ENSPREP00000029748	Solute carrier family 11 member 2.	Solute carrier family 11 member 2.	0.901
SLC11A2	ndfip1	ENSPREP00000020123	ENSPREP00000007942	Solute carrier family 11 member 2.	Nedd4 family interacting protein 1, like.	0.491
itch	LOC103464828	ENSPREP00000001984	ENSPREP00000023584	E3 ubiquitin-protein ligase.	E3 ubiquitin-protein ligase.	0.901
itch	ndfip1	ENSPREP00000001984	ENSPREP00000007942	E3 ubiquitin-protein ligase.	Nedd4 family interacting protein 1, like.	0.420
itch	wwp1	ENSPREP00000001984	ENSPREP00000010715	E3 ubiquitin-protein ligase.	WW domain containing E3 ubiquitin protein ligase 1.	0.631
itch	wwp2	ENSPREP00000001984	ENSPREP00000004465	E3 ubiquitin-protein ligase.	E3 ubiquitin-protein ligase.	0.633
ndfip1	LOC103464828	ENSPREP00000007942	ENSPREP00000023584	Nedd4 family interacting protein 1, like.	E3 ubiquitin-protein ligase.	0.420
ndfip1	LOC103467973	ENSPREP00000007942	ENSPREP00000029748	Nedd4 family interacting protein 1, like.	Solute carrier family 11 member 2.	0.491
ndfip1	SLC11A2	ENSPREP00000007942	ENSPREP00000020123	Nedd4 family interacting protein 1, like.	Solute carrier family 11 member 2.	0.491
ndfip1	itch	ENSPREP00000007942	ENSPREP00000001984	Nedd4 family interacting protein 1, like.	E3 ubiquitin-protein ligase.	0.420
ndfip1	ndufa6	ENSPREP00000007942	ENSPREP00000024483	Nedd4 family interacting protein 1, like.	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.	0.468
ndfip1	nedd4	ENSPREP00000007942	ENSPREP00000001056	Nedd4 family interacting protein 1, like.	E3 ubiquitin-protein ligase.	0.502
ndfip1	nedd4l	ENSPREP00000007942	ENSPREP00000026475	Nedd4 family interacting protein 1, like.	NEDD4 like E3 ubiquitin protein ligase.	0.502
ndfip1	trip12	ENSPREP00000007942	ENSPREP00000026747	Nedd4 family interacting protein 1, like.	Thyroid hormone receptor interactor 12.	0.563

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

52

average node degree:

9.45

avg. local clustering coefficient:

0.958

expected number of edges:

12

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0045216

Cell-cell junction organization

7 of 80

2.02

3.88

1.23e-09

GO:0070830

Bicellular tight junction assembly

5 of 22

2.43

3.75

4.91e-08

GO:0016338

Calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules

3 of 7

2.71

2.36

4.50e-05

GO:0007155

Cell adhesion

7 of 431

1.29

1.49

1.40e-05

GO:0043117

Positive regulation of vascular permeability

2 of 3

2.9

1.29

0.0046

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005198

Structural molecule activity

5 of 418

1.15

0.62

0.0332

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005923

Bicellular tight junction

7 of 51

2.21

5.04

9.34e-12

GO:0030054

Cell junction

9 of 1029

1.02

1.15

1.42e-06

GO:0005886

Plasma membrane

9 of 2817

0.58

0.42

0.0064

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:16536

Tight junction

6 of 12

2.77

6.03

3.32e-12

CL:16539

Tight junction

4 of 7

2.83

3.83

8.05e-08

CL:9444

Amphiphysin, and Dynamin stalk domain

2 of 5

2.68

1.12

0.0092

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04530

Tight junction

7 of 127

1.82

3.52

6.17e-10

map04514

Cell adhesion molecules

5 of 105

1.75

2.42

1.64e-06

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-420029

Tight junction interactions

5 of 14

2.63

4.49

2.69e-09

MAP-421270

Cell-cell junction organization

5 of 46

2.11

3.14

2.68e-07

MAP-446728

Cell junction organization

5 of 80

1.87

2.51

2.46e-06

MAP-1500931

Cell-Cell communication

5 of 97

1.79

2.32

4.66e-06

MAP-157858

Gap junction trafficking and regulation

3 of 38

1.97

1.43

0.0015

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0070160

Tight junction

6 of 29

2.39

4.85

1.46e-10

GOCC:0005923

Bicellular tight junction

4 of 22

2.34

3.0

1.38e-06

GOCC:0030054

Cell junction

8 of 524

1.26

1.65

4.79e-07

GOCC:0098835

Presynaptic endocytic zone membrane

2 of 4

2.77

1.5

0.0019

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0796

Tight junction

5 of 14

2.63

4.85

4.84e-10

KW-1003

Cell membrane

5 of 178

1.52

1.79

2.11e-05

KW-0342

GTP-binding

3 of 124

1.46

0.91

0.0101

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF13903

PMP-22/EMP/MP20/Claudin tight junction

3 of 15

2.38

1.74

0.00055

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR006187

Claudin

5 of 15

2.6

4.17

1.11e-08

IPR004031

PMP-22/EMP/MP20/Claudin superfamily

5 of 32

2.27

3.39

1.55e-07

IPR017974

Claudin, conserved site

4 of 12

2.6

3.24

8.15e-07

IPR020850

GTPase effector domain

3 of 3

3.08

2.73

1.10e-05

IPR019762

Dynamin, GTPase region, conserved site

3 of 3

3.08

2.73

1.10e-05

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00302

Dynamin GTPase effector domain

3 of 3

3.08

2.89

5.67e-06

SM00053

Dynamin, GTPase

3 of 4

2.95

2.87

5.67e-06

SM00072

Guanylate kinase homologues.

2 of 19

2.1

0.83

0.0287

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