TMEM43 protein (Poecilia reticulata) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
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Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

TMEM43

Uncharacterized protein. (403 aa)

Predicted Functional Partners:

ncln

0.550

LOC103465321

0.549

smpd4

0.549

LOC103464606

0.548

kcng3

0.538

prr35

0.536

themis2

0.532

fbxl5

0.532

bahd1

0.528

ift140

0.528

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC103464606	TMEM43	ENSPREP00000002349	ENSPREP00000008122	Kelch repeat and BTB (POZ) domain containing 12.	Uncharacterized protein.	0.548
LOC103464606	ift140	ENSPREP00000002349	ENSPREP00000027530	Kelch repeat and BTB (POZ) domain containing 12.	Intraflagellar transport 140 homolog (Chlamydomonas).	0.541
LOC103464606	kcng3	ENSPREP00000002349	ENSPREP00000007351	Kelch repeat and BTB (POZ) domain containing 12.	Potassium voltage-gated channel, subfamily G, member 3; Belongs to the potassium channel family.	0.550
LOC103464606	prr35	ENSPREP00000002349	ENSPREP00000027670	Kelch repeat and BTB (POZ) domain containing 12.	Si:ch211-248l17.3.	0.549
LOC103465321	TMEM43	ENSPREP00000000600	ENSPREP00000008122	Junction plakoglobin a.	Uncharacterized protein.	0.549
TMEM43	LOC103464606	ENSPREP00000008122	ENSPREP00000002349	Uncharacterized protein.	Kelch repeat and BTB (POZ) domain containing 12.	0.548
TMEM43	LOC103465321	ENSPREP00000008122	ENSPREP00000000600	Uncharacterized protein.	Junction plakoglobin a.	0.549
TMEM43	bahd1	ENSPREP00000008122	ENSPREP00000024499	Uncharacterized protein.	Bromo adjacent homology domain containing 1.	0.528
TMEM43	fbxl5	ENSPREP00000008122	ENSPREP00000027490	Uncharacterized protein.	F-box and leucine-rich repeat protein 5.	0.532
TMEM43	ift140	ENSPREP00000008122	ENSPREP00000027530	Uncharacterized protein.	Intraflagellar transport 140 homolog (Chlamydomonas).	0.528
TMEM43	kcng3	ENSPREP00000008122	ENSPREP00000007351	Uncharacterized protein.	Potassium voltage-gated channel, subfamily G, member 3; Belongs to the potassium channel family.	0.538
TMEM43	ncln	ENSPREP00000008122	ENSPREP00000025810	Uncharacterized protein.	Nicalin.	0.550
TMEM43	prr35	ENSPREP00000008122	ENSPREP00000027670	Uncharacterized protein.	Si:ch211-248l17.3.	0.536
TMEM43	smpd4	ENSPREP00000008122	ENSPREP00000031033	Uncharacterized protein.	Sphingomyelin phosphodiesterase 4.	0.549
TMEM43	themis2	ENSPREP00000008122	ENSPREP00000007474	Uncharacterized protein.	Thymocyte selection associated family member 2.	0.532
bahd1	TMEM43	ENSPREP00000024499	ENSPREP00000008122	Bromo adjacent homology domain containing 1.	Uncharacterized protein.	0.528
bahd1	fbxl5	ENSPREP00000024499	ENSPREP00000027490	Bromo adjacent homology domain containing 1.	F-box and leucine-rich repeat protein 5.	0.528
bahd1	themis2	ENSPREP00000024499	ENSPREP00000007474	Bromo adjacent homology domain containing 1.	Thymocyte selection associated family member 2.	0.528
fbxl5	TMEM43	ENSPREP00000027490	ENSPREP00000008122	F-box and leucine-rich repeat protein 5.	Uncharacterized protein.	0.532
fbxl5	bahd1	ENSPREP00000027490	ENSPREP00000024499	F-box and leucine-rich repeat protein 5.	Bromo adjacent homology domain containing 1.	0.528

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

41

average node degree:

7.45

avg. local clustering coefficient:

0.869

expected number of edges:

13

PPI enrichment p-value:

2.15e-10

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000077

DNA damage checkpoint signaling

7 of 79

2.27

5.21

6.50e-12

GO:0044773

Mitotic DNA damage checkpoint signaling

6 of 63

2.3

4.64

2.28e-10

GO:0071479

Cellular response to ionizing radiation

5 of 38

2.44

4.27

3.82e-09

GO:0007095

Mitotic G2 DNA damage checkpoint signaling

5 of 41

2.4

4.2

4.66e-09

GO:0006281

DNA repair

10 of 415

1.7

3.87

1.94e-13

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030870

Mre11 complex

3 of 3

3.32

3.31

1.04e-06

GO:0000781

Chromosome, telomeric region

4 of 56

2.17

2.62

5.85e-06

GO:0031436

BRCA1-BARD1 complex

2 of 3

3.14

2.02

0.00022

GO:0000794

Condensed nuclear chromosome

3 of 49

2.1

1.87

0.00021

GO:0035861

Site of double-strand break

3 of 52

2.08

1.86

0.00022

(more ...)

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:32796846

(2020) A scalable CRISPRCas9-based fluorescent reporter assay to study DNA double-strand break repair choice.

3 of 25

2.4

1.95

0.00022

PMID:38102134

(2023) Whole-genome sequencing reveals the molecular implications of the stepwise progression of lung adenocarcinoma.

3 of 42

2.17

1.73

0.00048

PMID:33742045

(2021) Short and long-read genome sequencing methodologies for somatic variant detection; genomic analysis of a patient with diffuse large B-cell lymphoma.

2 of 11

2.58

1.28

0.0045

PMID:37627523

(2023) Natural Acetogenins, Chatenaytrienins-1, -2, -3 and -4, Mitochondrial Potential Uncouplers and Autophagy Inducers-Promising Anticancer Agents.

2 of 36

2.06

0.81

0.0301

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:7103

Mixed, incl. Mre11 complex, and BRCA1-BARD1 complex

9 of 11

3.23

12.3

9.80e-24

CL:7105

Mre11 complex, and Flap-structured DNA binding

4 of 5

3.22

4.77

2.02e-09

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

pret03440

Homologous recombination

5 of 27

2.59

5.06

1.47e-10

pret04218

Cellular senescence

8 of 178

1.97

4.81

4.42e-13

pret04115

p53 signaling pathway

5 of 78

2.12

3.67

1.40e-08

pret04110

Cell cycle

5 of 120

1.94

3.11

8.41e-08

pret03450

Non-homologous end-joining

2 of 11

2.58

1.77

0.00054

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-69473

G2/M DNA damage checkpoint

10 of 101

2.31

8.16

8.73e-20

MAP-6804756

Regulation of TP53 Activity through Phosphorylation

10 of 125

2.22

7.56

3.33e-19

MAP-5685938

HDR through Single Strand Annealing (SSA)

7 of 45

2.51

6.75

1.61e-14

MAP-5693616

Presynaptic phase of homologous DNA pairing and strand exchange

6 of 24

2.72

6.57

1.91e-13

MAP-5693579

Homologous DNA Pairing and Strand Exchange

6 of 26

2.68

6.48

2.49e-13

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0030870

Mre11 complex

4 of 5

3.22

4.53

5.58e-09

GOCC:0031436

BRCA1-BARD1 complex

2 of 5

2.92

1.46

0.0023

GOCC:0070531

BRCA1-A complex

2 of 15

2.44

1.12

0.0087

GOCC:0005634

Nucleus

10 of 3523

0.77

0.71

5.55e-05

GOCC:0043229

Intracellular organelle

11 of 9083

0.4

0.31

0.0100

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0227

DNA damage

2 of 27

2.19

0.84

0.0283

KW-0723

Serine/threonine-protein kinase

3 of 233

1.43

0.73

0.0283

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02259

FAT domain

2 of 4

3.02

1.19

0.0072

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036420

BRCT domain superfamily

4 of 27

2.49

2.75

6.43e-06

IPR001357

BRCT domain

3 of 23

2.43

1.68

0.00076

IPR003151

PIK-related kinase, FAT

2 of 4

3.02

1.18

0.0075

IPR014009

PIK-related kinase

2 of 5

2.92

1.17

0.0078

IPR003152

FATC domain

2 of 6

2.84

1.15

0.0083

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00292

Breast cancer carboxy-terminal domain

4 of 22

2.58

3.42

3.35e-07

SM01343

The FATC domain is named after FRAP, ATM, TRRAP C-terminal (PMID:10782091). The solution structure of the FATC domain suggests it plays a role in redox-dependent structural and cellular stability (PMID:15772072).

2 of 6

2.84

1.45

0.0023

SM00240

Forkhead associated domain

2 of 27

2.19

0.89

0.0220

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