fkbp4 protein (Poecilia reticulata) - STRING interaction network

Nodes:

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

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Coexpression

Experiments

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[Homology]

Score

fkbp4

Peptidylprolyl isomerase. (448 aa)

Predicted Functional Partners:

stip1

0.872

adsl

0.867

ENSPREP00000010558

0.840

LOC103467311

0.840

hsp90ab1

0.839

LOC103457917

0.839

HSP90AA1

0.839

pgr

0.786

Ppig

0.772

LOC103471211

0.757

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000010558	HSP90AA1	ENSPREP00000010558	ENSPREP00000020973	Prostaglandin E synthase 3b (cytosolic).	Heat shock protein 90 alpha family class A member 1.	0.902
ENSPREP00000010558	LOC103457917	ENSPREP00000010558	ENSPREP00000020946	Prostaglandin E synthase 3b (cytosolic).	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 1.	0.902
ENSPREP00000010558	LOC103471211	ENSPREP00000010558	ENSPREP00000006730	Prostaglandin E synthase 3b (cytosolic).	Nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor).	0.883
ENSPREP00000010558	Ppig	ENSPREP00000010558	ENSPREP00000004884	Prostaglandin E synthase 3b (cytosolic).	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family.	0.874
ENSPREP00000010558	fkbp4	ENSPREP00000010558	ENSPREP00000008181	Prostaglandin E synthase 3b (cytosolic).	Peptidylprolyl isomerase.	0.840
ENSPREP00000010558	hsp90ab1	ENSPREP00000010558	ENSPREP00000012481	Prostaglandin E synthase 3b (cytosolic).	Heat shock protein 90, alpha (cytosolic), class B member 1.	0.902
ENSPREP00000010558	pgr	ENSPREP00000010558	ENSPREP00000023028	Prostaglandin E synthase 3b (cytosolic).	Progesterone receptor.	0.719
ENSPREP00000010558	stip1	ENSPREP00000010558	ENSPREP00000008322	Prostaglandin E synthase 3b (cytosolic).	Stress-induced phosphoprotein 1.	0.938
HSP90AA1	ENSPREP00000010558	ENSPREP00000020973	ENSPREP00000010558	Heat shock protein 90 alpha family class A member 1.	Prostaglandin E synthase 3b (cytosolic).	0.902
HSP90AA1	LOC103467311	ENSPREP00000020973	ENSPREP00000032865	Heat shock protein 90 alpha family class A member 1.	Prostaglandin E synthase 3a (cytosolic).	0.902
HSP90AA1	LOC103471211	ENSPREP00000020973	ENSPREP00000006730	Heat shock protein 90 alpha family class A member 1.	Nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor).	0.782
HSP90AA1	Ppig	ENSPREP00000020973	ENSPREP00000004884	Heat shock protein 90 alpha family class A member 1.	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family.	0.826
HSP90AA1	fkbp4	ENSPREP00000020973	ENSPREP00000008181	Heat shock protein 90 alpha family class A member 1.	Peptidylprolyl isomerase.	0.839
HSP90AA1	hsp90ab1	ENSPREP00000020973	ENSPREP00000012481	Heat shock protein 90 alpha family class A member 1.	Heat shock protein 90, alpha (cytosolic), class B member 1.	0.410
HSP90AA1	pgr	ENSPREP00000020973	ENSPREP00000023028	Heat shock protein 90 alpha family class A member 1.	Progesterone receptor.	0.695
HSP90AA1	stip1	ENSPREP00000020973	ENSPREP00000008322	Heat shock protein 90 alpha family class A member 1.	Stress-induced phosphoprotein 1.	0.974
LOC103457917	ENSPREP00000010558	ENSPREP00000020946	ENSPREP00000010558	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 1.	Prostaglandin E synthase 3b (cytosolic).	0.902
LOC103457917	LOC103467311	ENSPREP00000020946	ENSPREP00000032865	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 1.	Prostaglandin E synthase 3a (cytosolic).	0.902
LOC103457917	LOC103471211	ENSPREP00000020946	ENSPREP00000006730	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 1.	Nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor).	0.782
LOC103457917	Ppig	ENSPREP00000020946	ENSPREP00000004884	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 1.	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family.	0.826

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Network Stats

number of nodes:

11

number of edges:

27

average node degree:

4.91

avg. local clustering coefficient:

0.783

expected number of edges:

12

PPI enrichment p-value:

0.00012

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0007018

Microtubule-based movement

6 of 308

1.61

1.88

2.26e-05

GO:0046586

Regulation of calcium-dependent cell-cell adhesion

2 of 2

3.32

1.5

0.0020

GO:0007406

Negative regulation of neuroblast proliferation

2 of 3

3.14

1.42

0.0028

GO:0000070

Mitotic sister chromatid segregation

3 of 88

1.85

1.05

0.0089

GO:0070229

Negative regulation of lymphocyte apoptotic process

2 of 11

2.58

1.05

0.0121

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008574

Plus-end-directed microtubule motor activity

3 of 21

2.47

1.8

0.00045

GO:0019894

Kinesin binding

3 of 40

2.19

1.6

0.00090

GO:0120170

Intraciliary transport particle B binding

2 of 4

3.02

1.48

0.0021

GO:0008017

Microtubule binding

4 of 271

1.49

1.09

0.0034

GO:0008092

Cytoskeletal protein binding

7 of 1110

1.12

1.02

0.00045

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005871

Kinesin complex

4 of 63

2.12

2.42

1.38e-05

GO:0016939

Kinesin II complex

2 of 2

3.32

2.04

0.00021

GO:0005828

Kinetochore microtubule

2 of 4

3.02

1.9

0.00036

GO:0097730

Non-motile cilium

4 of 123

1.83

1.84

0.00012

GO:0005876

Spindle microtubule

3 of 49

2.1

1.84

0.00025

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:17888

Intraciliary transport particle, and Kinesin II complex

4 of 27

2.49

2.82

4.52e-06

CL:8090

Mixed, incl. Mitotic spindle midzone, and Spindle elongation

3 of 13

2.68

2.51

2.31e-05

CL:17865

Mixed, incl. Transport along microtubule, and Kinesins

5 of 175

1.77

2.18

1.06e-05

CL:17932

Kinesin II complex, and Microtubule anchoring at centrosome

2 of 5

2.92

1.61

0.0012

CL:17896

Intraciliary transport particle B

2 of 5

2.92

1.61

0.0012

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-983189

Kinesins

6 of 98

2.1

3.79

5.77e-09

MAP-6811434

COPI-dependent Golgi-to-ER retrograde traffic

6 of 161

1.89

3.11

5.17e-08

MAP-8856688

Golgi-to-ER retrograde transport

6 of 191

1.81

2.9

9.36e-08

MAP-2132295

MHC class II antigen presentation

6 of 213

1.77

2.77

1.33e-07

MAP-983231

Factors involved in megakaryocyte development and platelet production

6 of 217

1.76

2.76

1.33e-07

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0016939

Kinesin II complex

2 of 3

3.14

1.66

0.0010

GOCC:0005871

Kinesin complex

3 of 43

2.16

1.58

0.00095

GOCC:0015630

Microtubule cytoskeleton

6 of 556

1.35

1.38

0.00014

GOCC:0051233

Spindle midzone

2 of 12

2.54

1.25

0.0052

GOCC:0005876

Spindle microtubule

2 of 17

2.39

1.17

0.0069

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0505

Motor protein

4 of 118

1.85

1.91

8.26e-05

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01088

Ubiquitin carboxyl-terminal hydrolase, family 1

2 of 4

3.02

1.19

0.0072

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR001752

Kinesin motor domain

4 of 54

2.19

2.09

8.61e-05

IPR036961

Kinesin motor domain superfamily

4 of 109

1.88

1.57

0.00064

IPR041507

Peptidase C12, C-terminal domain

2 of 2

3.32

1.46

0.0024

IPR008658

Kinesin-associated protein 3

2 of 2

3.32

1.46

0.0024

IPR027640

Kinesin-like protein

3 of 40

2.19

1.39

0.0024

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00129

Kinesin motor, catalytic domain. ATPase.

4 of 51

2.21

2.59

7.58e-06

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