stip1 protein (Poecilia reticulata) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

stip1

Stress-induced phosphoprotein 1. (574 aa)

Predicted Functional Partners:

hsp90ab1

0.974

LOC103457917

0.974

HSP90AA1

0.974

trap1

0.953

tsc1

0.953

LOC103458156

0.939

ahsa1

0.939

ENSPREP00000010558

0.938

LOC103467311

0.938

LOC103471205

0.930

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000010558	HSP90AA1	ENSPREP00000010558	ENSPREP00000020973	Prostaglandin E synthase 3b (cytosolic).	Heat shock protein 90 alpha family class A member 1.	0.902
ENSPREP00000010558	LOC103457917	ENSPREP00000010558	ENSPREP00000020946	Prostaglandin E synthase 3b (cytosolic).	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 1.	0.902
ENSPREP00000010558	LOC103458156	ENSPREP00000010558	ENSPREP00000008620	Prostaglandin E synthase 3b (cytosolic).	AHA1, activator of heat shock protein ATPase homolog 1b.	0.716
ENSPREP00000010558	LOC103471205	ENSPREP00000010558	ENSPREP00000007443	Prostaglandin E synthase 3b (cytosolic).	Heat shock protein 4b.	0.499
ENSPREP00000010558	ahsa1	ENSPREP00000010558	ENSPREP00000020402	Prostaglandin E synthase 3b (cytosolic).	Aha1_N domain-containing protein.	0.716
ENSPREP00000010558	hsp90ab1	ENSPREP00000010558	ENSPREP00000012481	Prostaglandin E synthase 3b (cytosolic).	Heat shock protein 90, alpha (cytosolic), class B member 1.	0.902
ENSPREP00000010558	stip1	ENSPREP00000010558	ENSPREP00000008322	Prostaglandin E synthase 3b (cytosolic).	Stress-induced phosphoprotein 1.	0.938
ENSPREP00000010558	trap1	ENSPREP00000010558	ENSPREP00000011122	Prostaglandin E synthase 3b (cytosolic).	TNF receptor-associated protein 1.	0.870
ENSPREP00000010558	tsc1	ENSPREP00000010558	ENSPREP00000032075	Prostaglandin E synthase 3b (cytosolic).	TSC complex subunit 1b.	0.870
HSP90AA1	ENSPREP00000010558	ENSPREP00000020973	ENSPREP00000010558	Heat shock protein 90 alpha family class A member 1.	Prostaglandin E synthase 3b (cytosolic).	0.902
HSP90AA1	LOC103458156	ENSPREP00000020973	ENSPREP00000008620	Heat shock protein 90 alpha family class A member 1.	AHA1, activator of heat shock protein ATPase homolog 1b.	0.790
HSP90AA1	LOC103467311	ENSPREP00000020973	ENSPREP00000032865	Heat shock protein 90 alpha family class A member 1.	Prostaglandin E synthase 3a (cytosolic).	0.902
HSP90AA1	LOC103471205	ENSPREP00000020973	ENSPREP00000007443	Heat shock protein 90 alpha family class A member 1.	Heat shock protein 4b.	0.830
HSP90AA1	ahsa1	ENSPREP00000020973	ENSPREP00000020402	Heat shock protein 90 alpha family class A member 1.	Aha1_N domain-containing protein.	0.790
HSP90AA1	hsp90ab1	ENSPREP00000020973	ENSPREP00000012481	Heat shock protein 90 alpha family class A member 1.	Heat shock protein 90, alpha (cytosolic), class B member 1.	0.410
HSP90AA1	stip1	ENSPREP00000020973	ENSPREP00000008322	Heat shock protein 90 alpha family class A member 1.	Stress-induced phosphoprotein 1.	0.974
LOC103457917	ENSPREP00000010558	ENSPREP00000020946	ENSPREP00000010558	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 1.	Prostaglandin E synthase 3b (cytosolic).	0.902
LOC103457917	LOC103458156	ENSPREP00000020946	ENSPREP00000008620	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 1.	AHA1, activator of heat shock protein ATPase homolog 1b.	0.790
LOC103457917	LOC103467311	ENSPREP00000020946	ENSPREP00000032865	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 1.	Prostaglandin E synthase 3a (cytosolic).	0.902
LOC103457917	LOC103471205	ENSPREP00000020946	ENSPREP00000007443	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 1.	Heat shock protein 4b.	0.746

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Network Stats

number of nodes:

11

number of edges:

20

average node degree:

3.64

avg. local clustering coefficient:

0.872

expected number of edges:

10

PPI enrichment p-value:

0.00363

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0044772

Mitotic cell cycle phase transition

7 of 105

2.14

4.55

7.76e-11

GO:0000079

Regulation of cyclin-dependent protein serine/threonine kinase activity

6 of 72

2.24

4.33

7.98e-10

GO:1903047

Mitotic cell cycle process

9 of 402

1.67

3.29

7.76e-11

GO:0051301

Cell division

7 of 393

1.57

2.39

1.20e-07

GO:0051726

Regulation of cell cycle

8 of 702

1.37

1.98

1.14e-07

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016538

Cyclin-dependent protein serine/threonine kinase regulator activity

5 of 52

2.3

3.51

9.84e-08

GO:0003688

DNA replication origin binding

2 of 13

2.5

1.06

0.0118

GO:0030234

Enzyme regulator activity

6 of 1134

1.04

0.78

0.0038

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000307

Cyclin-dependent protein kinase holoenzyme complex

5 of 40

2.41

4.0

1.35e-08

GO:0097124

Cyclin A2-CDK2 complex

2 of 3

3.14

1.81

0.00053

GO:0005813

Centrosome

4 of 419

1.3

0.9

0.0062

GO:0015630

Microtubule cytoskeleton

5 of 1092

0.98

0.64

0.0128

GO:0005634

Nucleus

10 of 6688

0.49

0.37

0.0062

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:37288606

(2023) Cytoplasmic Polyadenylation Is an Ancestral Hallmark of Early Development in Animals.

4 of 15

2.74

3.77

9.20e-08

PMID:24742317

(2014) Comparative analysis of the gonadal transcriptomes of the all-female species Poecilia formosa and its maternal ancestor Poecilia mexicana.

2 of 10

2.62

1.23

0.0057

PMID:24886435

(2014) Transcriptome assemblies for studying sex-biased gene expression in the guppy, Poecilia reticulata.

2 of 26

2.2

0.9

0.0216

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:7892

Cyclin-dependent protein serine/threonine kinase regulator activity, and Cyclin-dependent protein kinase activity

6 of 49

2.41

4.71

3.34e-10

CL:7953

Mixed, incl. G2/M DNA replication checkpoint, and Positive regulation of meiotic cell cycle phase transition

4 of 11

2.88

4.08

2.82e-08

CL:7890

Mixed, incl. Mitotic cell cycle phase transition, and Mitotic sister chromatid segregation

7 of 163

1.95

3.79

8.91e-10

CL:7246

DNA replication origin binding, and MCM domain

3 of 14

2.65

2.43

3.11e-05

CL:7900

G2 Phase, and Cyclin-dependent kinase inhibitor

2 of 5

2.92

1.53

0.0017

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

pret04110

Cell cycle

7 of 120

2.08

4.77

7.42e-12

pret04914

Progesterone-mediated oocyte maturation

4 of 88

1.98

2.45

6.58e-06

pret04218

Cellular senescence

3 of 178

1.54

1.09

0.0042

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-69273

Cyclin A/B1/B2 associated events during G2/M transition

7 of 36

2.61

6.96

1.36e-14

MAP-69478

G2/M DNA replication checkpoint

4 of 7

3.07

4.74

1.98e-09

MAP-69481

G2/M Checkpoints

8 of 189

1.94

4.59

1.41e-12

MAP-69620

Cell Cycle Checkpoints

10 of 344

1.78

4.42

1.26e-14

MAP-2995383

Initiation of Nuclear Envelope (NE) Reformation

4 of 19

2.64

3.94

3.54e-08

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0097124

Cyclin A2-CDK2 complex

3 of 4

3.19

2.95

4.43e-06

GOCC:0000307

Cyclin-dependent protein kinase holoenzyme complex

4 of 37

2.35

2.77

4.43e-06

GOCC:0000808

Origin recognition complex

2 of 7

2.77

1.48

0.0020

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0195

Cyclin

5 of 33

2.5

4.51

1.48e-09

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR004367

Cyclin, C-terminal domain

5 of 16

2.81

4.75

1.28e-09

IPR039361

Cyclin

5 of 20

2.72

4.64

1.66e-09

IPR006671

Cyclin, N-terminal

5 of 35

2.47

4.04

1.37e-08

IPR013763

Cyclin-like domain

5 of 37

2.45

4.02

1.37e-08

IPR036915

Cyclin-like superfamily

5 of 47

2.34

3.76

3.24e-08

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00385

Domain present in cyclins, TFIIB and Retinoblastoma

5 of 41

2.4

4.06

9.36e-09

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