| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| LOC103473119 | acadm | ENSPREP00000017837 | ENSPREP00000027231 | 3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. | Acyl-CoA dehydrogenase medium chain. | 0.612 |
| LOC103473119 | acadsb | ENSPREP00000017837 | ENSPREP00000010670 | 3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. | Acyl-CoA dehydrogenase short/branched chain. | 0.482 |
| LOC103473119 | acat2 | ENSPREP00000017837 | ENSPREP00000008323 | 3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. | Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family. | 0.994 |
| LOC103473119 | acox1 | ENSPREP00000017837 | ENSPREP00000029304 | 3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. | Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. | 0.563 |
| LOC103473119 | cs | ENSPREP00000017837 | ENSPREP00000033337 | 3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. | Citrate synthase; Belongs to the citrate synthase family. | 0.936 |
| LOC103473119 | ehhadh | ENSPREP00000017837 | ENSPREP00000013997 | 3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. | Enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase; Belongs to the enoyl-CoA hydratase/isomerase family. | 0.959 |
| LOC103473119 | hadh | ENSPREP00000017837 | ENSPREP00000003565 | 3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. | Hydroxyacyl-CoA dehydrogenase. | 0.946 |
| LOC103473119 | hadha | ENSPREP00000017837 | ENSPREP00000021058 | 3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. | Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha b; Belongs to the enoyl-CoA hydratase/isomerase family. | 0.592 |
| LOC103473119 | oxct1 | ENSPREP00000017837 | ENSPREP00000024269 | 3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. | Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. | 0.958 |
| acadm | LOC103473119 | ENSPREP00000027231 | ENSPREP00000017837 | Acyl-CoA dehydrogenase medium chain. | 3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. | 0.612 |
| acadm | acadsb | ENSPREP00000027231 | ENSPREP00000010670 | Acyl-CoA dehydrogenase medium chain. | Acyl-CoA dehydrogenase short/branched chain. | 0.954 |
| acadm | acat2 | ENSPREP00000027231 | ENSPREP00000008323 | Acyl-CoA dehydrogenase medium chain. | Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family. | 0.964 |
| acadm | acox1 | ENSPREP00000027231 | ENSPREP00000029304 | Acyl-CoA dehydrogenase medium chain. | Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. | 0.964 |
| acadm | acox3 | ENSPREP00000027231 | ENSPREP00000004131 | Acyl-CoA dehydrogenase medium chain. | Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. | 0.956 |
| acadm | cs | ENSPREP00000027231 | ENSPREP00000033337 | Acyl-CoA dehydrogenase medium chain. | Citrate synthase; Belongs to the citrate synthase family. | 0.786 |
| acadm | ehhadh | ENSPREP00000027231 | ENSPREP00000013997 | Acyl-CoA dehydrogenase medium chain. | Enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase; Belongs to the enoyl-CoA hydratase/isomerase family. | 0.979 |
| acadm | hadh | ENSPREP00000027231 | ENSPREP00000003565 | Acyl-CoA dehydrogenase medium chain. | Hydroxyacyl-CoA dehydrogenase. | 0.947 |
| acadm | hadha | ENSPREP00000027231 | ENSPREP00000021058 | Acyl-CoA dehydrogenase medium chain. | Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha b; Belongs to the enoyl-CoA hydratase/isomerase family. | 0.994 |
| acadm | oxct1 | ENSPREP00000027231 | ENSPREP00000024269 | Acyl-CoA dehydrogenase medium chain. | Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. | 0.625 |
| acadsb | LOC103473119 | ENSPREP00000010670 | ENSPREP00000017837 | Acyl-CoA dehydrogenase short/branched chain. | 3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. | 0.482 |