Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
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Co-expression
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[Homology]
Score
IGFBP3Insulin like growth factor binding protein 3. (285 aa)    
Predicted Functional Partners:
igf1
Insulin-like growth factor 1.
   
 0.999
igfals
Insulin-like growth factor binding protein, acid labile subunit.
    
 0.966
LOC103466958
IlGF domain-containing protein.
     
 0.916
igfbp3
Insulin-like growth factor binding protein 3.
  
  
 
0.902
LOC103466132
CD44 molecule (Indian blood group) b.
    
 
 0.891
apaf1
Apoptotic peptidase activating factor 1.
     
 0.880
ENSPREP00000031599
LRRCT domain-containing protein.
    
 0.871
bnip3
BCL2 interacting protein 3.
      
 0.823
igf2
IlGF domain-containing protein.
   
 0.809
tp53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
    
 0.734
Your Current Organism:
Poecilia reticulata
NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy
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