STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
cdc73Cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae). (576 aa)    
Predicted Functional Partners:
paf1
PAF1 homolog, Paf1/RNA polymerase II complex component.
   
 0.999
wdr61
WD repeat domain 61.
    
 0.999
leo1
LEO1 homolog, Paf1/RNA polymerase II complex component.
   
 0.999
rtf1
RTF1 homolog, Paf1/RNA polymerase II complex component.
   
 0.999
ctr9
CTR9 homolog, Paf1/RNA polymerase II complex component.
   
 0.999
supt16h
SPT16 homolog, facilitates chromatin remodeling subunit.
   
 0.981
ssrp1
FACT complex subunit SSRP1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...]
   
 0.976
POLR2E
RNA polymerase II subunit E.
   
 0.974
polr2h
DNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively.
    
 0.972
supt4h1
SPT4 homolog, DSIF elongation factor subunit.
    
 0.972
Your Current Organism:
Poecilia reticulata
NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.