MRPL49 protein (Poecilia reticulata) - STRING interaction network

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

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Score

MRPL49

Mitochondrial ribosomal protein L49. (172 aa)

Predicted Functional Partners:

mrpl43

0.995

mrpl19

0.994

mrpl36

0.993

dap3

0.993

mrpl15

0.992

mrpl4

0.992

mrpl27

0.991

mrpl30

0.989

mrpl17

0.989

mrps16

0.988

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
MRPL49	dap3	ENSPREP00000008399	ENSPREP00000026175	Mitochondrial ribosomal protein L49.	Death associated protein 3.	0.993
MRPL49	mrpl15	ENSPREP00000008399	ENSPREP00000009782	Mitochondrial ribosomal protein L49.	Mitochondrial ribosomal protein L15.	0.992
MRPL49	mrpl17	ENSPREP00000008399	ENSPREP00000021683	Mitochondrial ribosomal protein L49.	Mitochondrial ribosomal protein L17; Belongs to the bacterial ribosomal protein bL17 family.	0.989
MRPL49	mrpl19	ENSPREP00000008399	ENSPREP00000008688	Mitochondrial ribosomal protein L49.	Mitochondrial ribosomal protein L19.	0.994
MRPL49	mrpl27	ENSPREP00000008399	ENSPREP00000025645	Mitochondrial ribosomal protein L49.	Mitochondrial ribosomal protein L27.	0.991
MRPL49	mrpl30	ENSPREP00000008399	ENSPREP00000012607	Mitochondrial ribosomal protein L49.	Mitochondrial ribosomal protein L30.	0.989
MRPL49	mrpl36	ENSPREP00000008399	ENSPREP00000025687	Mitochondrial ribosomal protein L49.	Ribosomal protein; Belongs to the bacterial ribosomal protein bL36 family.	0.993
MRPL49	mrpl4	ENSPREP00000008399	ENSPREP00000031967	Mitochondrial ribosomal protein L49.	Mitochondrial ribosomal protein L4.	0.992
MRPL49	mrpl43	ENSPREP00000008399	ENSPREP00000016253	Mitochondrial ribosomal protein L49.	Mitochondrial ribosomal protein L43.	0.995
MRPL49	mrps16	ENSPREP00000008399	ENSPREP00000008484	Mitochondrial ribosomal protein L49.	Mitochondrial ribosomal protein S16.	0.988
dap3	MRPL49	ENSPREP00000026175	ENSPREP00000008399	Death associated protein 3.	Mitochondrial ribosomal protein L49.	0.993
dap3	mrpl15	ENSPREP00000026175	ENSPREP00000009782	Death associated protein 3.	Mitochondrial ribosomal protein L15.	0.993
dap3	mrpl17	ENSPREP00000026175	ENSPREP00000021683	Death associated protein 3.	Mitochondrial ribosomal protein L17; Belongs to the bacterial ribosomal protein bL17 family.	0.987
dap3	mrpl19	ENSPREP00000026175	ENSPREP00000008688	Death associated protein 3.	Mitochondrial ribosomal protein L19.	0.990
dap3	mrpl27	ENSPREP00000026175	ENSPREP00000025645	Death associated protein 3.	Mitochondrial ribosomal protein L27.	0.991
dap3	mrpl30	ENSPREP00000026175	ENSPREP00000012607	Death associated protein 3.	Mitochondrial ribosomal protein L30.	0.980
dap3	mrpl36	ENSPREP00000026175	ENSPREP00000025687	Death associated protein 3.	Ribosomal protein; Belongs to the bacterial ribosomal protein bL36 family.	0.982
dap3	mrpl4	ENSPREP00000026175	ENSPREP00000031967	Death associated protein 3.	Mitochondrial ribosomal protein L4.	0.990
dap3	mrpl43	ENSPREP00000026175	ENSPREP00000016253	Death associated protein 3.	Mitochondrial ribosomal protein L43.	0.983
dap3	mrps16	ENSPREP00000026175	ENSPREP00000008484	Death associated protein 3.	Mitochondrial ribosomal protein S16.	0.999

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

45

average node degree:

8.18

avg. local clustering coefficient:

0.962

expected number of edges:

21

PPI enrichment p-value:

2.12e-06

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000398

mRNA splicing, via spliceosome

7 of 114

1.93

3.7

1.29e-09

GO:0000387

Spliceosomal snRNP assembly

4 of 13

2.63

3.67

1.22e-07

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003723

RNA binding

8 of 570

1.29

1.69

7.21e-07

GO:0017069

snRNA binding

2 of 10

2.45

1.03

0.0129

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005685

U1 snRNP

6 of 9

2.97

7.13

4.16e-14

GO:0005686

U2 snRNP

6 of 18

2.67

6.38

3.72e-13

GO:0071011

Precatalytic spliceosome

6 of 20

2.62

6.24

5.45e-13

GO:0097525

Spliceosomal snRNP complex

7 of 41

2.38

6.11

1.32e-13

GO:0005682

U5 snRNP

5 of 10

2.84

5.76

1.42e-11

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:8704

U2 snRNP, and snRNA binding

8 of 19

2.77

8.8

5.04e-18

CL:8701

Small nuclear ribonucleoprotein complex, and snRNA binding

9 of 35

2.55

8.7

6.73e-19

CL:8706

U1 snRNP, and KH domain

6 of 10

2.92

7.1

4.17e-14

CL:8709

SLBP independent Processing of Histone Pre-mRNAs

4 of 5

3.05

4.63

3.12e-09

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03040

Spliceosome

9 of 158

1.9

4.93

1.25e-14

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-111367

SLBP independent Processing of Histone Pre-mRNAs

5 of 6

3.07

6.0

8.13e-12

MAP-77588

SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs

5 of 7

3.0

5.92

1.04e-11

MAP-75067

Processing of Capped Intronless Pre-mRNA

5 of 22

2.5

4.67

7.06e-10

MAP-72172

mRNA Splicing

9 of 177

1.85

4.47

2.02e-13

MAP-73856

RNA Polymerase II Transcription Termination

5 of 50

2.14

3.62

2.26e-08

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0097525

Spliceosomal snRNP complex

6 of 26

2.51

5.52

9.83e-12

GOCC:0005689

U12-type spliceosomal complex

5 of 11

2.8

5.46

4.87e-11

GOCC:0005682

U5 snRNP

5 of 11

2.8

5.46

4.87e-11

GOCC:0005687

U4 snRNP

4 of 7

2.9

4.45

5.77e-09

GOCC:1990904

Ribonucleoprotein complex

9 of 258

1.69

3.57

5.83e-12

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0508

mRNA splicing

6 of 16

2.72

6.41

4.24e-13

KW-0687

Ribonucleoprotein

6 of 75

2.05

4.05

6.04e-10

KW-0747

Spliceosome

3 of 10

2.62

2.92

3.50e-06

KW-0539

Nucleus

6 of 297

1.45

1.95

1.34e-06

KW-0694

RNA-binding

4 of 140

1.6

1.7

8.71e-05

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR047575

Sm domain

6 of 17

2.69

5.75

8.59e-12

IPR001163

Sm domain, eukaryotic/archaea-type

6 of 17

2.69

5.75

8.59e-12

IPR010920

LSM domain superfamily

6 of 21

2.6

5.66

8.59e-12

IPR034099

Small nuclear ribonucleoprotein Sm D3

2 of 2

3.14

1.45

0.0024

IPR027141

Like-Sm (LSM) domain containing protein, LSm4/SmD1/SmD3

2 of 3

2.97

1.39

0.0031

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00651

snRNP Sm proteins

6 of 17

2.69

6.22

8.97e-13

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