node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ENSPREP00000000563 | mtap | ENSPREP00000000563 | ENSPREP00000008657 | Methylthioribose-1-phosphate isomerase 1; Belongs to the eIF-2B alpha/beta/delta subunits family. | S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates. | 0.747 |
ENSPREP00000000563 | sms | ENSPREP00000000563 | ENSPREP00000029181 | Methylthioribose-1-phosphate isomerase 1; Belongs to the eIF-2B alpha/beta/delta subunits family. | Spermine synthase. | 0.675 |
ENSPREP00000000563 | srm | ENSPREP00000000563 | ENSPREP00000024069 | Methylthioribose-1-phosphate isomerase 1; Belongs to the eIF-2B alpha/beta/delta subunits family. | Spermidine synthase; Belongs to the spermidine/spermine synthase family. | 0.701 |
LOC103466391 | Topors | ENSPREP00000008243 | ENSPREP00000008624 | Programmed cell death 4a. | RING-type domain-containing protein. | 0.839 |
LOC103466391 | cdkn2b | ENSPREP00000008243 | ENSPREP00000008747 | Programmed cell death 4a. | Cyclin-dependent kinase inhibitor 2A/B (p15, inhibits CDK4). | 0.469 |
LOC103466391 | mtap | ENSPREP00000008243 | ENSPREP00000008657 | Programmed cell death 4a. | S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates. | 0.825 |
Topors | LOC103466391 | ENSPREP00000008624 | ENSPREP00000008243 | RING-type domain-containing protein. | Programmed cell death 4a. | 0.839 |
Topors | cdkn2b | ENSPREP00000008624 | ENSPREP00000008747 | RING-type domain-containing protein. | Cyclin-dependent kinase inhibitor 2A/B (p15, inhibits CDK4). | 0.457 |
Topors | mtap | ENSPREP00000008624 | ENSPREP00000008657 | RING-type domain-containing protein. | S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates. | 0.825 |
cdkn2b | LOC103466391 | ENSPREP00000008747 | ENSPREP00000008243 | Cyclin-dependent kinase inhibitor 2A/B (p15, inhibits CDK4). | Programmed cell death 4a. | 0.469 |
cdkn2b | Topors | ENSPREP00000008747 | ENSPREP00000008624 | Cyclin-dependent kinase inhibitor 2A/B (p15, inhibits CDK4). | RING-type domain-containing protein. | 0.457 |
cdkn2b | mtap | ENSPREP00000008747 | ENSPREP00000008657 | Cyclin-dependent kinase inhibitor 2A/B (p15, inhibits CDK4). | S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates. | 0.728 |
cdkn2b | prmt5 | ENSPREP00000008747 | ENSPREP00000032537 | Cyclin-dependent kinase inhibitor 2A/B (p15, inhibits CDK4). | Protein arginine N-methyltransferase 5; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA); Belongs to the class I-like SAM-binding methyltransferase superfamily. | 0.404 |
ephx2 | mtap | ENSPREP00000021989 | ENSPREP00000008657 | Epoxide hydrolase 2, cytoplasmic. | S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates. | 0.891 |
ephx2 | nt5e | ENSPREP00000021989 | ENSPREP00000017485 | Epoxide hydrolase 2, cytoplasmic. | 5'-nucleotidase ecto; Belongs to the 5'-nucleotidase family. | 0.885 |
ephx2 | sms | ENSPREP00000021989 | ENSPREP00000029181 | Epoxide hydrolase 2, cytoplasmic. | Spermine synthase. | 0.566 |
mtap | ENSPREP00000000563 | ENSPREP00000008657 | ENSPREP00000000563 | S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates. | Methylthioribose-1-phosphate isomerase 1; Belongs to the eIF-2B alpha/beta/delta subunits family. | 0.747 |
mtap | LOC103466391 | ENSPREP00000008657 | ENSPREP00000008243 | S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates. | Programmed cell death 4a. | 0.825 |
mtap | Topors | ENSPREP00000008657 | ENSPREP00000008624 | S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates. | RING-type domain-containing protein. | 0.825 |
mtap | cdkn2b | ENSPREP00000008657 | ENSPREP00000008747 | S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates. | Cyclin-dependent kinase inhibitor 2A/B (p15, inhibits CDK4). | 0.728 |