sos1 protein (Poecilia reticulata) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

sos1

Son of sevenless homolog 1 (Drosophila). (1138 aa)

Predicted Functional Partners:

grb2

0.997

LOC103469088

0.965

kras

0.965

hras

0.965

EGFR

0.961

egfr

0.961

rras2

0.948

LOC103468146

0.947

mras

0.947

LOC103469672

0.946

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EGFR	LOC103469088	ENSPREP00000015371	ENSPREP00000020359	Receptor protein-tyrosine kinase.	Zgc:55558.	0.521
EGFR	egfr	ENSPREP00000015371	ENSPREP00000025280	Receptor protein-tyrosine kinase.	Receptor protein-tyrosine kinase.	0.902
EGFR	grb2	ENSPREP00000015371	ENSPREP00000022510	Receptor protein-tyrosine kinase.	Growth factor receptor-bound protein 2b.	0.981
EGFR	hras	ENSPREP00000015371	ENSPREP00000028573	Receptor protein-tyrosine kinase.	HRas proto-oncogene, GTPase a.	0.511
EGFR	kras	ENSPREP00000015371	ENSPREP00000027060	Receptor protein-tyrosine kinase.	V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog.	0.713
EGFR	sos1	ENSPREP00000015371	ENSPREP00000008888	Receptor protein-tyrosine kinase.	Son of sevenless homolog 1 (Drosophila).	0.961
LOC103468146	grb2	ENSPREP00000009362	ENSPREP00000022510	RAS related.	Growth factor receptor-bound protein 2b.	0.524
LOC103468146	sos1	ENSPREP00000009362	ENSPREP00000008888	RAS related.	Son of sevenless homolog 1 (Drosophila).	0.947
LOC103469088	EGFR	ENSPREP00000020359	ENSPREP00000015371	Zgc:55558.	Receptor protein-tyrosine kinase.	0.521
LOC103469088	egfr	ENSPREP00000020359	ENSPREP00000025280	Zgc:55558.	Receptor protein-tyrosine kinase.	0.521
LOC103469088	grb2	ENSPREP00000020359	ENSPREP00000022510	Zgc:55558.	Growth factor receptor-bound protein 2b.	0.667
LOC103469088	hras	ENSPREP00000020359	ENSPREP00000028573	Zgc:55558.	HRas proto-oncogene, GTPase a.	0.910
LOC103469088	kras	ENSPREP00000020359	ENSPREP00000027060	Zgc:55558.	V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog.	0.901
LOC103469088	sos1	ENSPREP00000020359	ENSPREP00000008888	Zgc:55558.	Son of sevenless homolog 1 (Drosophila).	0.965
LOC103469672	grb2	ENSPREP00000001007	ENSPREP00000022510	Fibroblast growth factor receptor.	Growth factor receptor-bound protein 2b.	0.920
LOC103469672	sos1	ENSPREP00000001007	ENSPREP00000008888	Fibroblast growth factor receptor.	Son of sevenless homolog 1 (Drosophila).	0.946
egfr	EGFR	ENSPREP00000025280	ENSPREP00000015371	Receptor protein-tyrosine kinase.	Receptor protein-tyrosine kinase.	0.902
egfr	LOC103469088	ENSPREP00000025280	ENSPREP00000020359	Receptor protein-tyrosine kinase.	Zgc:55558.	0.521
egfr	grb2	ENSPREP00000025280	ENSPREP00000022510	Receptor protein-tyrosine kinase.	Growth factor receptor-bound protein 2b.	0.981
egfr	hras	ENSPREP00000025280	ENSPREP00000028573	Receptor protein-tyrosine kinase.	HRas proto-oncogene, GTPase a.	0.511

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

27

average node degree:

4.91

avg. local clustering coefficient:

0.804

expected number of edges:

10

PPI enrichment p-value:

1.45e-05

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0007097

Nuclear migration

6 of 29

2.49

4.89

2.29e-10

GO:0051642

Centrosome localization

5 of 34

2.35

3.6

7.49e-08

GO:1902017

Regulation of cilium assembly

4 of 46

2.12

2.24

3.54e-05

GO:0046907

Intracellular transport

7 of 997

1.03

0.88

0.00086

GO:0033043

Regulation of organelle organization

5 of 761

1.0

0.51

0.0484

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0140444

Cytoskeleton-nuclear membrane anchor activity

5 of 11

2.84

4.97

5.07e-10

GO:0060090

Molecular adaptor activity

6 of 308

1.47

1.74

1.64e-05

GO:0051015

Actin filament binding

4 of 212

1.45

1.03

0.0045

GO:0008092

Cytoskeletal protein binding

5 of 842

0.95

0.5

0.0479

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0034993

Meiotic nuclear membrane microtubule tethering complex

5 of 14

2.73

4.85

6.70e-10

GO:0005640

Nuclear outer membrane

4 of 24

2.4

3.27

4.65e-07

GO:0031965

Nuclear membrane

6 of 179

1.7

2.6

2.05e-07

GO:0030017

Sarcomere

4 of 143

1.63

1.54

0.00031

GO:0098590

Plasma membrane region

6 of 773

1.07

0.97

0.00040

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:19246

Cytoskeleton-nuclear membrane anchor activity, and Lamin tail domain superfamily

6 of 18

2.7

5.78

7.80e-12

CL:19248

Cytoskeleton-nuclear membrane anchor activity

5 of 10

2.88

5.31

1.21e-10

CL:14822

Mixed, incl. EH domain, and T-complex protein 10, C-terminal domain superfamily

4 of 11

2.74

3.78

8.69e-08

CL:19250

Cytoskeleton-nuclear membrane anchor activity

2 of 5

2.78

1.52

0.0017

CL:14825

T-complex protein 10, C-terminal domain superfamily, and EH domain

2 of 5

2.78

1.52

0.0017

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1474165

Reproduction

5 of 42

2.25

3.45

1.10e-07

MAP-1640170

Cell Cycle

6 of 665

1.13

0.94

0.0014

Tissue Expression (TISSUES)

tissue

description

count in network

strength

signal

false discovery rate

BTO:0000562

Heart

4 of 225

1.43

1.5

9.65e-05

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0034993

Meiotic nuclear membrane microtubule tethering complex

5 of 12

2.8

4.99

4.16e-10

GOCC:0031965

Nuclear membrane

4 of 68

1.95

2.18

2.68e-05

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR012315

KASH domain

2 of 3

3.0

0.9

0.0241

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM01249

Nuclear envelope localisation domain

2 of 3

3.0

1.4

0.0029

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (26%) [HD]

Permalink

Network

Cooccurrence

Experiments

Coexpression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2025

Credits

Access

Info

About