klf12 protein (Poecilia reticulata) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

klf12

Kruppel-like factor 12b. (386 aa)

Predicted Functional Partners:

ENSPREP00000004786

0.707

zbtb10

0.557

znf276

0.556

dclre1b

0.556

srbd1

0.555

ENSPREP00000011081

0.531

nr2c2

0.500

nr2c1

0.499

LOC103467637

0.488

PCBP2

0.488

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000004786	klf12	ENSPREP00000004786	ENSPREP00000008972	AF4/FMR2 family, member 2.	Kruppel-like factor 12b.	0.707
ENSPREP00000011081	LOC103467637	ENSPREP00000011081	ENSPREP00000009073	Nuclear apoptosis inducing factor 1.	Poly(rC) binding protein 2.	0.483
ENSPREP00000011081	PCBP2	ENSPREP00000011081	ENSPREP00000011363	Nuclear apoptosis inducing factor 1.	Poly(rC) binding protein 2.	0.483
ENSPREP00000011081	dclre1b	ENSPREP00000011081	ENSPREP00000033608	Nuclear apoptosis inducing factor 1.	DNA cross-link repair 1B.	0.560
ENSPREP00000011081	klf12	ENSPREP00000011081	ENSPREP00000008972	Nuclear apoptosis inducing factor 1.	Kruppel-like factor 12b.	0.531
ENSPREP00000011081	nr2c1	ENSPREP00000011081	ENSPREP00000006105	Nuclear apoptosis inducing factor 1.	Nuclear receptor subfamily 2, group C, member 1.	0.479
ENSPREP00000011081	nr2c2	ENSPREP00000011081	ENSPREP00000024735	Nuclear apoptosis inducing factor 1.	Nuclear receptor subfamily 2, group C, member 2.	0.481
ENSPREP00000011081	srbd1	ENSPREP00000011081	ENSPREP00000004800	Nuclear apoptosis inducing factor 1.	S1 RNA binding domain 1.	0.553
ENSPREP00000011081	zbtb10	ENSPREP00000011081	ENSPREP00000011821	Nuclear apoptosis inducing factor 1.	Zinc finger and BTB domain containing 10.	0.550
ENSPREP00000011081	znf276	ENSPREP00000011081	ENSPREP00000031022	Nuclear apoptosis inducing factor 1.	Zinc finger protein 276.	0.550
LOC103467637	ENSPREP00000011081	ENSPREP00000009073	ENSPREP00000011081	Poly(rC) binding protein 2.	Nuclear apoptosis inducing factor 1.	0.483
LOC103467637	PCBP2	ENSPREP00000009073	ENSPREP00000011363	Poly(rC) binding protein 2.	Poly(rC) binding protein 2.	0.900
LOC103467637	dclre1b	ENSPREP00000009073	ENSPREP00000033608	Poly(rC) binding protein 2.	DNA cross-link repair 1B.	0.484
LOC103467637	klf12	ENSPREP00000009073	ENSPREP00000008972	Poly(rC) binding protein 2.	Kruppel-like factor 12b.	0.488
LOC103467637	srbd1	ENSPREP00000009073	ENSPREP00000004800	Poly(rC) binding protein 2.	S1 RNA binding domain 1.	0.481
LOC103467637	zbtb10	ENSPREP00000009073	ENSPREP00000011821	Poly(rC) binding protein 2.	Zinc finger and BTB domain containing 10.	0.486
LOC103467637	znf276	ENSPREP00000009073	ENSPREP00000031022	Poly(rC) binding protein 2.	Zinc finger protein 276.	0.486
PCBP2	ENSPREP00000011081	ENSPREP00000011363	ENSPREP00000011081	Poly(rC) binding protein 2.	Nuclear apoptosis inducing factor 1.	0.483
PCBP2	LOC103467637	ENSPREP00000011363	ENSPREP00000009073	Poly(rC) binding protein 2.	Poly(rC) binding protein 2.	0.900
PCBP2	dclre1b	ENSPREP00000011363	ENSPREP00000033608	Poly(rC) binding protein 2.	DNA cross-link repair 1B.	0.484

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

39

average node degree:

7.09

avg. local clustering coefficient:

0.919

expected number of edges:

10

PPI enrichment p-value:

5.16e-12

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006696

Ergosterol biosynthetic process

8 of 23

2.06

4.77

4.99e-12

GO:0008299

Isoprenoid biosynthetic process

6 of 14

2.15

4.17

9.02e-10

GO:0019287

Isopentenyl diphosphate biosynthetic process, mevalonate pathway

4 of 4

2.52

3.35

4.07e-07

GO:0006721

Terpenoid metabolic process

4 of 7

2.28

2.94

1.63e-06

GO:0045338

Farnesyl diphosphate metabolic process

3 of 6

2.22

2.0

0.00014

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:4427

Ergosterol metabolic process

7 of 17

2.13

4.61

4.79e-11

CL:4451

Isopentenyl diphosphate biosynthetic process, mevalonate pathway

4 of 5

2.42

3.2

6.74e-07

CL:4429

Steroid biosynthesis

3 of 11

1.95

1.57

0.00075

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00900

Terpenoid backbone biosynthesis

5 of 22

1.88

2.68

8.45e-07

map00100

Steroid biosynthesis

3 of 14

1.85

1.57

0.00057

map01110

Biosynthesis of secondary metabolites

8 of 204

1.11

1.33

1.02e-06

map01100

Metabolic pathways

8 of 639

0.62

0.47

0.0029

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-191273

Cholesterol biosynthesis

6 of 18

2.04

3.55

1.45e-08

MAP-8957322

Metabolism of steroids

6 of 37

1.73

2.59

3.22e-07

MAP-556833

Metabolism of lipids

7 of 130

1.25

1.48

6.84e-06

MAP-1430728

Metabolism

7 of 484

0.68

0.42

0.0303

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0753

Steroid metabolism

3 of 6

2.22

1.82

0.00033

KW-0752

Steroid biosynthesis

3 of 6

2.22

1.82

0.00033

KW-0756

Sterol biosynthesis

2 of 5

2.12

1.15

0.0068

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00288

GHMP kinases N terminal domain

3 of 3

2.52

2.04

0.00016

PF08544

GHMP kinases C terminal

2 of 2

2.52

1.1

0.0097

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR006204

GHMP kinase N-terminal domain

3 of 3

2.52

1.75

0.00059

IPR014721

Ribosomal protein S5 domain 2-type fold, subgroup

3 of 17

1.77

0.91

0.0163

IPR036554

GHMP kinase, C-terminal domain superfamily

2 of 2

2.52

0.89

0.0238

IPR013750

GHMP kinase, C-terminal domain

2 of 2

2.52

0.89

0.0238

IPR020568

Ribosomal protein S5 domain 2-type fold

3 of 24

1.62

0.8

0.0238

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (28%) [HD]

Permalink

Network

Cooccurrence

Experiments

Coexpression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2025

Credits

Access

Info

About