dennd2d protein (Poecilia reticulata) - STRING interaction network

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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co-expression

protein homology

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[Homology]

Score

dennd2d

DENN/MADD domain containing 2Da. (584 aa)

Predicted Functional Partners:

ift27

0.690

LOC103460653

0.690

rab35

0.690

Suox

0.549

LOC103459897

0.463

ENSPREP00000010233

0.458

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000010233	LOC103459897	ENSPREP00000010233	ENSPREP00000005116	RAB9B, member RAS oncogene family.	Rab proteins geranylgeranyltransferase component A; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.	0.676
ENSPREP00000010233	dennd2d	ENSPREP00000010233	ENSPREP00000009171	RAB9B, member RAS oncogene family.	DENN/MADD domain containing 2Da.	0.458
LOC103459897	ENSPREP00000010233	ENSPREP00000005116	ENSPREP00000010233	Rab proteins geranylgeranyltransferase component A; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.	RAB9B, member RAS oncogene family.	0.676
LOC103459897	LOC103460653	ENSPREP00000005116	ENSPREP00000007773	Rab proteins geranylgeranyltransferase component A; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.	Si:dkey-16l2.16.	0.658
LOC103459897	dennd2d	ENSPREP00000005116	ENSPREP00000009171	Rab proteins geranylgeranyltransferase component A; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.	DENN/MADD domain containing 2Da.	0.463
LOC103459897	ift27	ENSPREP00000005116	ENSPREP00000000211	Rab proteins geranylgeranyltransferase component A; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.	Intraflagellar transport 27.	0.611
LOC103459897	rab35	ENSPREP00000005116	ENSPREP00000023082	Rab proteins geranylgeranyltransferase component A; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.	RAB35, member RAS oncogene family b.	0.658
LOC103460653	LOC103459897	ENSPREP00000007773	ENSPREP00000005116	Si:dkey-16l2.16.	Rab proteins geranylgeranyltransferase component A; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.	0.658
LOC103460653	dennd2d	ENSPREP00000007773	ENSPREP00000009171	Si:dkey-16l2.16.	DENN/MADD domain containing 2Da.	0.690
Suox	dennd2d	ENSPREP00000021510	ENSPREP00000009171	Sulfite oxidase.	DENN/MADD domain containing 2Da.	0.549
dennd2d	ENSPREP00000010233	ENSPREP00000009171	ENSPREP00000010233	DENN/MADD domain containing 2Da.	RAB9B, member RAS oncogene family.	0.458
dennd2d	LOC103459897	ENSPREP00000009171	ENSPREP00000005116	DENN/MADD domain containing 2Da.	Rab proteins geranylgeranyltransferase component A; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.	0.463
dennd2d	LOC103460653	ENSPREP00000009171	ENSPREP00000007773	DENN/MADD domain containing 2Da.	Si:dkey-16l2.16.	0.690
dennd2d	Suox	ENSPREP00000009171	ENSPREP00000021510	DENN/MADD domain containing 2Da.	Sulfite oxidase.	0.549
dennd2d	ift27	ENSPREP00000009171	ENSPREP00000000211	DENN/MADD domain containing 2Da.	Intraflagellar transport 27.	0.690
dennd2d	rab35	ENSPREP00000009171	ENSPREP00000023082	DENN/MADD domain containing 2Da.	RAB35, member RAS oncogene family b.	0.690
ift27	LOC103459897	ENSPREP00000000211	ENSPREP00000005116	Intraflagellar transport 27.	Rab proteins geranylgeranyltransferase component A; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.	0.611
ift27	dennd2d	ENSPREP00000000211	ENSPREP00000009171	Intraflagellar transport 27.	DENN/MADD domain containing 2Da.	0.690
rab35	LOC103459897	ENSPREP00000023082	ENSPREP00000005116	RAB35, member RAS oncogene family b.	Rab proteins geranylgeranyltransferase component A; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.	0.658
rab35	dennd2d	ENSPREP00000023082	ENSPREP00000009171	RAB35, member RAS oncogene family b.	DENN/MADD domain containing 2Da.	0.690

Network Stats

number of nodes:

11

number of edges:

44

average node degree:

8

avg. local clustering coefficient:

0.825

expected number of edges:

10

PPI enrichment p-value:

9.21e-15

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009058

Biosynthetic process

9 of 320

0.57

0.35

0.0380

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005737

Cytoplasm

11 of 482

0.48

0.4

0.00045

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:993

Peptidoglycan synthesis, and Cell division site

4 of 18

1.47

1.08

0.0035

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00473

D-Alanine metabolism

4 of 4

2.12

2.46

1.11e-05

map01502

Vancomycin resistance

3 of 6

1.82

1.42

0.0012

map00290

Valine, leucine and isoleucine biosynthesis

2 of 2

2.12

1.14

0.0071

map01210

2-Oxocarboxylic acid metabolism

2 of 5

1.72

0.89

0.0174

map00550

Peptidoglycan biosynthesis

3 of 25

1.2

0.72

0.0174

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0573

Peptidoglycan synthesis

3 of 12

1.52

0.8

0.0214

KW-0961

Cell wall biogenesis/degradation

3 of 13

1.48

0.79

0.0214

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