STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
spry1Sprouty homolog 1, antagonist of FGF signaling (Drosophila). (358 aa)    
Predicted Functional Partners:
grb2
Growth factor receptor-bound protein 2b.
    
 
 0.700
LOC103477907
Cbl proto-oncogene C, E3 ubiquitin protein ligase.
    
 0.681
LOC103476312
Uncharacterized protein.
    
 0.681
cbl
Cbl proto-oncogene, E3 ubiquitin protein ligase.
    
 0.681
egf
Epidermal growth factor.
     
 0.625
LOC103476047
Sprouty RTK signaling antagonist 2.
  
0.624
LOC103469984
EGF-like domain-containing protein.
     
 0.605
spry4
Sprouty homolog 4 (Drosophila).
   
0.570
SPRY3
Sprouty RTK signaling antagonist 3.
  
0.570
pdgfc
Platelet derived growth factor c; Belongs to the PDGF/VEGF growth factor family.
      
 0.549
Your Current Organism:
Poecilia reticulata
NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.