STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
notch1Notch receptor 1b. (2491 aa)    
Predicted Functional Partners:
LOC103469257
Recombination signal binding protein for immunoglobulin kappa J region a.
   
 0.991
rbpj
Recombination signal binding protein for immunoglobulin kappa J region.
   
 0.991
NCSTN
Nicastrin.
    
 0.980
LOC103458084
Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.
   
0.976
jag1
Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.
   
0.976
psen2
Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.
    
 0.965
aph1a
APH1B gamma secretase subunit.
    
 0.960
LOC103474847
NUMB like endocytic adaptor protein.
   
 0.948
numb
NUMB endocytic adaptor protein.
   
 0.948
Adam17
Pep_M12B_propep domain-containing protein.
    
 0.936
Your Current Organism:
Poecilia reticulata
NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.