ENSPREP00000009645 protein (Poecilia reticulata)

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second shell of interactors

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Edges:

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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Score

ENSPREP00000009645

Uncharacterized protein. (197 aa)

Predicted Functional Partners:

LOC103457498

0.620

LOC103462739

0.574

LOC103466191

0.538

LOC103465076

0.523

arhgap35

0.523

LOC103458174

0.444

LOC103471993

0.421

wnt3a

0.416

wnt3

0.416

tbxt

0.405

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000009645	LOC103457498	ENSPREP00000009645	ENSPREP00000006894	Uncharacterized protein.	Mesogenin 1.	0.620
ENSPREP00000009645	LOC103458174	ENSPREP00000009645	ENSPREP00000010150	Uncharacterized protein.	Notochord homeobox.	0.444
ENSPREP00000009645	LOC103462739	ENSPREP00000009645	ENSPREP00000013200	Uncharacterized protein.	Mesoderm posterior aa.	0.574
ENSPREP00000009645	LOC103465076	ENSPREP00000009645	ENSPREP00000025034	Uncharacterized protein.	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4a.	0.523
ENSPREP00000009645	LOC103466191	ENSPREP00000009645	ENSPREP00000030949	Uncharacterized protein.	Solute carrier family 41 member 2a.	0.538
ENSPREP00000009645	LOC103471993	ENSPREP00000009645	ENSPREP00000021918	Uncharacterized protein.	T-box transcription factor Ta.	0.421
ENSPREP00000009645	arhgap35	ENSPREP00000009645	ENSPREP00000033748	Uncharacterized protein.	Uncharacterized protein.	0.523
ENSPREP00000009645	tbxt	ENSPREP00000009645	ENSPREP00000034173	Uncharacterized protein.	T-box transcription factor Tb.	0.405
ENSPREP00000009645	wnt3	ENSPREP00000009645	ENSPREP00000017531	Uncharacterized protein.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.416
ENSPREP00000009645	wnt3a	ENSPREP00000009645	ENSPREP00000011284	Uncharacterized protein.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.416
LOC103457498	ENSPREP00000009645	ENSPREP00000006894	ENSPREP00000009645	Mesogenin 1.	Uncharacterized protein.	0.620
LOC103457498	LOC103471993	ENSPREP00000006894	ENSPREP00000021918	Mesogenin 1.	T-box transcription factor Ta.	0.456
LOC103457498	tbxt	ENSPREP00000006894	ENSPREP00000034173	Mesogenin 1.	T-box transcription factor Tb.	0.455
LOC103458174	ENSPREP00000009645	ENSPREP00000010150	ENSPREP00000009645	Notochord homeobox.	Uncharacterized protein.	0.444
LOC103458174	LOC103471993	ENSPREP00000010150	ENSPREP00000021918	Notochord homeobox.	T-box transcription factor Ta.	0.730
LOC103458174	tbxt	ENSPREP00000010150	ENSPREP00000034173	Notochord homeobox.	T-box transcription factor Tb.	0.582
LOC103462739	ENSPREP00000009645	ENSPREP00000013200	ENSPREP00000009645	Mesoderm posterior aa.	Uncharacterized protein.	0.574
LOC103465076	ENSPREP00000009645	ENSPREP00000025034	ENSPREP00000009645	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4a.	Uncharacterized protein.	0.523
LOC103465076	LOC103466191	ENSPREP00000025034	ENSPREP00000030949	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4a.	Solute carrier family 41 member 2a.	0.681
LOC103465076	arhgap35	ENSPREP00000025034	ENSPREP00000033748	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4a.	Uncharacterized protein.	0.681

page 1 of 2

Network Stats

number of nodes:

6

number of edges:

6

average node degree:

2

avg. local clustering coefficient:

0.85

expected number of edges:

5

PPI enrichment p-value:

0.449

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0072583

Clathrin-dependent endocytosis

7 of 28

2.58

6.31

2.86e-13

GO:0006898

Receptor-mediated endocytosis

8 of 99

2.09

5.0

1.65e-12

GO:0048268

Clathrin coat assembly

3 of 14

2.51

1.93

0.00026

GO:0150007

Clathrin-dependent synaptic vesicle endocytosis

2 of 3

3.0

1.23

0.0060

GO:2000253

Positive regulation of feeding behavior

2 of 5

2.78

1.16

0.0080

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0035615

Clathrin adaptor activity

3 of 13

2.54

2.05

0.00016

GO:0060090

Molecular adaptor activity

6 of 308

1.47

1.62

4.92e-05

GO:0017124

SH3 domain binding

3 of 87

1.72

0.94

0.0131

GO:0008289

Lipid binding

5 of 619

1.09

0.7

0.0131

GO:0019904

Protein domain specific binding

4 of 407

1.17

0.6

0.0403

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005905

Clathrin-coated pit

8 of 59

2.31

6.39

9.77e-15

GO:0030122

AP-2 adaptor complex

4 of 4

3.18

4.56

4.80e-09

GO:0030136

Clathrin-coated vesicle

5 of 95

1.9

2.82

4.23e-07

GO:0031410

Cytoplasmic vesicle

6 of 1351

0.83

0.6

0.0059

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:14816

Clathrin-dependent endocytosis, and EH domain

11 of 37

2.65

11.76

1.25e-25

CL:14819

Clathrin-dependent endocytosis, and Clathrin coat

9 of 31

2.64

9.58

2.07e-20

CL:14821

Mixed, incl. EH domain, and Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain

8 of 16

2.88

9.58

2.81e-19

CL:14822

Mixed, incl. EH domain, and T-complex protein 10, C-terminal domain superfamily

6 of 11

2.92

7.01

5.99e-14

CL:14825

T-complex protein 10, C-terminal domain superfamily, and EH domain

3 of 5

2.96

2.99

3.42e-06

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-8856828

Clathrin-mediated endocytosis

8 of 161

1.88

4.04

2.59e-11

MAP-8856825

Cargo recognition for clathrin-mediated endocytosis

5 of 108

1.84

2.48

2.48e-06

MAP-199991

Membrane Trafficking

8 of 701

1.24

1.55

1.29e-06

MAP-5653656

Vesicle-mediated transport

8 of 783

1.19

1.44

2.05e-06

MAP-5140745

WNT5A-dependent internalization of FZD2, FZD5 and ROR2

2 of 8

2.58

1.22

0.0060

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005905

Clathrin-coated pit

5 of 29

2.42

3.93

1.86e-08

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0254

Endocytosis

2 of 4

2.88

1.5

0.0019

KW-0168

Coated pit

2 of 6

2.7

1.49

0.0019

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR000261

EH domain

3 of 10

2.66

1.87

0.00037

IPR011992

EF-hand domain pair

4 of 207

1.47

0.77

0.0236

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00027

Eps15 homology domain

2 of 8

2.58

1.04

0.0130

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