LOC103476642 protein (Poecilia reticulata) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

LOC103476642

Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (725 aa)

Predicted Functional Partners:

ctnnb1

0.969

LOC103465321

0.919

LOC103472282

0.819

LOC103463938

0.787

CTNND1

0.787

ARVCF

0.787

PARD3

0.786

pard3

0.786

LOC103471147

0.696

ctnna2

0.696

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARVCF	LOC103465321	ENSPREP00000027715	ENSPREP00000000600	ARVCF delta catenin family member b.	Junction plakoglobin a.	0.717
ARVCF	LOC103471147	ENSPREP00000027715	ENSPREP00000009514	ARVCF delta catenin family member b.	Catenin (cadherin-associated protein), alpha 1.	0.695
ARVCF	LOC103472282	ENSPREP00000027715	ENSPREP00000005903	ARVCF delta catenin family member b.	Uncharacterized protein.	0.635
ARVCF	LOC103476642	ENSPREP00000027715	ENSPREP00000010042	ARVCF delta catenin family member b.	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	0.787
ARVCF	ctnna2	ENSPREP00000027715	ENSPREP00000013533	ARVCF delta catenin family member b.	Catenin (cadherin-associated protein), alpha 2.	0.695
ARVCF	ctnnb1	ENSPREP00000027715	ENSPREP00000019419	ARVCF delta catenin family member b.	Catenin (cadherin-associated protein), beta 1.	0.836
CTNND1	LOC103463938	ENSPREP00000026535	ENSPREP00000002099	Catenin delta 1.	Catenin (cadherin-associated protein), delta 1.	0.902
CTNND1	LOC103465321	ENSPREP00000026535	ENSPREP00000000600	Catenin delta 1.	Junction plakoglobin a.	0.717
CTNND1	LOC103471147	ENSPREP00000026535	ENSPREP00000009514	Catenin delta 1.	Catenin (cadherin-associated protein), alpha 1.	0.695
CTNND1	LOC103472282	ENSPREP00000026535	ENSPREP00000005903	Catenin delta 1.	Uncharacterized protein.	0.635
CTNND1	LOC103476642	ENSPREP00000026535	ENSPREP00000010042	Catenin delta 1.	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	0.787
CTNND1	ctnna2	ENSPREP00000026535	ENSPREP00000013533	Catenin delta 1.	Catenin (cadherin-associated protein), alpha 2.	0.760
CTNND1	ctnnb1	ENSPREP00000026535	ENSPREP00000019419	Catenin delta 1.	Catenin (cadherin-associated protein), beta 1.	0.836
LOC103463938	CTNND1	ENSPREP00000002099	ENSPREP00000026535	Catenin (cadherin-associated protein), delta 1.	Catenin delta 1.	0.902
LOC103463938	LOC103465321	ENSPREP00000002099	ENSPREP00000000600	Catenin (cadherin-associated protein), delta 1.	Junction plakoglobin a.	0.717
LOC103463938	LOC103471147	ENSPREP00000002099	ENSPREP00000009514	Catenin (cadherin-associated protein), delta 1.	Catenin (cadherin-associated protein), alpha 1.	0.695
LOC103463938	LOC103472282	ENSPREP00000002099	ENSPREP00000005903	Catenin (cadherin-associated protein), delta 1.	Uncharacterized protein.	0.635
LOC103463938	LOC103476642	ENSPREP00000002099	ENSPREP00000010042	Catenin (cadherin-associated protein), delta 1.	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	0.787
LOC103463938	ctnna2	ENSPREP00000002099	ENSPREP00000013533	Catenin (cadherin-associated protein), delta 1.	Catenin (cadherin-associated protein), alpha 2.	0.760
LOC103463938	ctnnb1	ENSPREP00000002099	ENSPREP00000019419	Catenin (cadherin-associated protein), delta 1.	Catenin (cadherin-associated protein), beta 1.	0.836

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

21

average node degree:

3.82

avg. local clustering coefficient:

0.865

expected number of edges:

11

PPI enrichment p-value:

0.00479

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006325

Chromatin organization

7 of 181

1.11

0.97

0.00072

GO:0016571

Histone methylation

3 of 17

1.77

0.76

0.0339

GO:0031497

Chromatin assembly

4 of 75

1.25

0.6

0.0450

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0035097

Histone methyltransferase complex

3 of 13

1.88

1.04

0.0094

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1126

Histone methylation, and Structural constituent of chromatin

9 of 28

2.03

5.49

7.82e-15

CL:1122

Mixed, incl. Histone methylation, and Structural constituent of chromatin

10 of 46

1.86

4.89

2.47e-15

CL:1128

Histone lysine methylation, and Structural constituent of chromatin

6 of 21

1.98

3.66

3.28e-09

CL:1129

Structural constituent of chromatin, and AWS domain

4 of 15

1.95

2.32

1.22e-05

CL:1172

Regulation of PTEN gene transcription, and JmjN domain

3 of 5

2.3

2.16

7.43e-05

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04130

SNARE interactions in vesicular transport

3 of 24

1.62

1.02

0.0072

map04145

Phagosome

3 of 39

1.41

0.84

0.0138

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-3214841

PKMTs methylate histone lysines

3 of 11

1.95

1.16

0.0057

MAP-4839726

Chromatin organization

4 of 58

1.36

0.88

0.0089

MAP-3247509

Chromatin modifying enzymes

4 of 58

1.36

0.88

0.0089

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0000786

Nucleosome

3 of 11

1.95

1.14

0.0062

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